Amino-Mag 200

• Amino-Mag, an "AMNI Original Formula", comes in a new Douglas Labs label. (AMNI is part of Douglas Labs).
• Amino-Mag 200 is a patented, nutritionally functional magnesium amino acid chelate (Albion Labs) with excellent bioavailability.
• Each tablet delivers 200 mg of elemental magnesium as a glycinate/lysinate (95/5%) chelate.

Amount Per Serving:

• Magnesium (amino acid chelate) 200 mg

Other Ingredients: Magnesium glycinate/lysinate, cellulose, vegetable stearine, silicon dioxide, and magnesium stearate.

Contains no yeast; corn; wheat; soya; sugar or other sweeteners; artificial flavors, colors or preservatives.

Recommended Dosage: One to two tablets daily as a dietary supplement, or as directed by physician. Take with food.

Warning: Dietary magnesium is generally safe and well tolerated. Excessive magnesium, i.e., intakes of 1,000 mg and more, may produce diarrhea.

STORAGE: Store in a cool, dry place, away from direct light. Keep out of reach of children. Amino-Mag 200 is very stable and maintains potency under normal conditions for at least two years.

FUNCTIONS:
Magnesium plays an essential role in a wide range of fundamental cellular reactions. More than 300 enzymes require magnesium as a cofactor. Complexed with ATP, the main carrier of metabolic energy in the body, magnesium is essential for all biosynthetic processes, glycolysis, formation of c-AMP, energy-dependent membrane transport, transmission of genetic code for protein synthesis, and muscle function.

Of the 20-30 grams of total body magnesium, about 40% is located in muscle and other soft tissues, and the remainder in bone. The concentration of intracellular magnesium is carefully regulated, and its alterations can have profound effects on cardiac and skeletal muscle physiology.

Healthy people require about 4.5 mg of dietary magnesium per kg body weight, or 280 mg for a 62 kg female and 350 mg for a 76 kg male. The U.S. RDA is 400 mg/day.

The efficiency of magnesium absorption is a function of dietary intake. At very low intakes (less than 40 mg) 65-70% of dietary magnesium is absorbed, whereas at high intakes (1,000 mg) less than 15% is absorbed. Most people are expected to absorb about 30-60% at common levels of dietary magnesium. Contrary to common belief, recent studies suggest that magnesium absorption is not affected by calcium or vitamin D, and vice-versa. The kidney plays a critical role in magnesium homeostasis. At average magnesium intakes, the kidneys reabsorb about 95% of the filtered magnesium.

Most magnesium supplements suffer from two major drawbacks: poor bioavailability and gastrointestinal side effects, most notably diarrhea. Magnesium oxide, the most frequently used form, is almost insoluble, very poorly absorbed (8-20%), and has laxative effects.

The Albion glycine/lysine chelate used in Amino-Mag 200 is 2-5 times better absorbed than magnesium from oxide, carbonate, or sulfate. This is because the magnesium chelate is absorbed intact via the efficient amino acid absorption pathway. Other forms of magnesium dissociate into free ionic magnesium which is subject to adverse nutrient interactions and a limited number of active absorptive sites on the intestinal mucosa. The magnesium amino acid chelate of Amino-Mag 200 is also better tolerated than the inorganic or ionic magnesium forms which are often the cause for diarrhea.

REFERENCES
1. Abbott L, Nadler J, Rude RK. Magnesium deficiency in alcoholism:Possible contribution to osteoporosis and cardiovascular disease in alcoholics. Alcoholism (NY) 1994;18:1076-1082.

2. Adaniya H, Hayami H, Hiraoka M, Sawanobori T. Effects of magnesium on polymorphic ventricular tachycardias induced by aconitine. J Cardiovasc Pharmacol 1994;24:721-729.

3. Al-Ghamdi SMG, Cameron EC, Sutton RAL. Magnesium deficiency: Pathophysiologic and clinical overview. Am J Kidney Dis 1994;24:737-752.

4. Dahle LO, Berg G, Hammar M, Hurtig M, Larsson L. The effect of oral magnesium substitution on pregnancy-induced leg cramps. Am J Obstet Gynecol 1995;173:175-180.

5. Durlach J, Durlach V, Bac P, Rayssiguier Y, Bara M, Guiet-Bara A.Magnesium and ageing. II. Clinical data: Aetiological mechanisms and pathophysiological consequences of magnesium deficit in the elderly. Magnes Res 1993;6:379-394.

6. Elin RJ. Magnesium: The fifth but forgotten electrolyte. Am J Clin Pathol 1994;102:616-622.

7. Kisters K, Spieker C, Tepel M, Zidek W. New data about the effects of oral physiological magnesium supplementation on several cardiovascular risk factors (lipids and blood pressure). Magnes Res 1993;6:355-360.

8. Lasserre B, Spoerri M, Moullet V, Theubet M-P. Should magnesium therapy be considered for the treatment of coronary heart disease? II. Epidemiological evidence in outpatients with and without coronary heart disease. Magnes Res 1994;7:145-153.

9. Orlov MV, Brodsky MA, Douban S. A review of magnesium, acute myocardial infarction and arrhythmia. J Am Coll Nutr 1994;13:127-132.

10. Rayssiguier Y, Durlach J, Gueux E, Rock E, Mazur A. Magnesium and ageing. I. Experimental data: Importance of oxidative damage. Magnes Res 1993;6:369-378.

11. Rock E, Astier C, Lab C, et al. Dietary magnesium deficiency in rats enhances free radical production in skeletal muscle. J Nutr 1995;125:1205-1210.

12. Schuette SA, Lashner BA, Janghorbani M. Bioavailability of magnesium diglycinate vs magnesium oxide in patients with ileal resection. J Parenter Enter Nutr 1994;18:430-435.

13. Seelig MS. Consequences of magnesium deficiency on the enhancement of stress reactions; Preventive and therapeutic implications. J Am Coll Nutr 1994;13:429-446.

14. Sojka JE, Weaver CM. Magnesium supplementation and osteoporosis. Nutr Rev 1995;53:71-74.

15. Spencer H, Fuller H, Norris C, Williams D. Effect of magnesium on the intestinal absorption of calcium in man. J Am Coll Nutr 1994;13:485- 492.

16. Thomas J, Tomb E, Thomas E, Faure G. Migraine treatment by oral magnesium intake and correction of the irritation of buccofacial and cervical muscles as a side effect of mandibular imbalance. Magnes Res 1994;7:123-127.

17. Wirell MP, Wester PO, Stegmayr BG. Nutritional dose of magnesium in hypertensive patients on beta blockers lowers systolic blood pressure: A double-blind, cross-over study. J Intern Med 1994;236:189-195.

18. Witteman JCM, Grobbee DE, Derkx FHM, Bouillon R, De Bruijn AM, Hofman A. Reduction of blood pressure with oral magnesium supplementation in women with mild to moderate hypertension. Am J Clin Nutr 1994;60:129-135.