This soothing topical cream can be used for discomfort caused by over-use of muscles or joints. It is a wonderful compliment to our encapsulated ArthroSoothe™ product. Topical application provides quick results with tissue-warming and surface-cooling effects utilizing a complex and complete formulation including Celadrin-R, a proprietary herbal blend (white willow bark, capsicum, arnica flowers, chamomile, and marigold), MSM (methylsulfonylmethane), emu oil, triethanolamine, aloe vera gel, glucosamine-chondroitin complex, menthol, cajeput oil, carbopol, hyaluronic acid, witch hazel, vitamin E, balsam of Peru, oil of oregano, and carnosine.
Ingredients: Purified Water, Celadrin®, Capryllic/Capric Triglyceride, Emu Oil, Triethanolamine, Proprietary Herbal Blend (White Willow Bark, Capsicum, Arnica Flowers, Chamomile, Marigold), MSM (Methylsulfonylmethane), Aloe Vera Gel, Glucosamine-Chondroitin Complex, Panalane (Hydrogenated Polyisobutene). Menthol, Cadjuput Oil, Carbopol, Hyaluronic Acid, Witch Hazel, Vitamin E, Balsam of Peru, Phenoxyethanol, Dimethicone, Oil of Oregano, Carnosine.
Massage into skin as needed for relief. Can be repeated several times a day as desired.
Store In A Cool, Dry Place. Keep Out Of Reach Of Children.
Read Customer questions and answers about Osteoarthritis in our FAQ.
ArthroSoothe Ingredients Mechanisms of Action
—Glucosamine Sulfate (1000 mg): Shown to prevent the Osteoarthritis even better when combined with MSM.
—Methylsulfonylmethane (MSM) (750 mg): Source of sulfur for making collagen, known to reduce pain and inflammation by blocking C fibers and reducing histamine release
—Hyaluronic Acid (20 mg): Lubricates and protects the joints, allows for smoother joint motion
—Zinc (as Zinc Chelazome®Bis-Glycinate Chelate) (10 mg): Needed for manufacture and maintenance of healthy cartilage, helps support activity of the inflammation-fighting enzyme superoxide dismutase (SOD).This enzyme is found in inflamed joints where it neutralizes free radicals. Zinc deficiency allows accelerated joint degeneration.
—Vitamin B3 (as Niacinamide) (500 mg): Inhibits IL-1 and PARP (poly ADP ribose polymerase) which keeps the immune system from attacking its own joint tissue
—Selenium (as Selenomethionine) (200 mcg): Helps make glutathione, a potent antioxidant
—Copper (1 mg): Cofactor in collagen synthesis (the fibers that compose ligaments, tendons and cartilage) and activation of the antioxidant enzyme copper-SOD
—Manganese (as Manganese Chelazome® Bis-Glycinate Chelate) (1 mg): Supports activity of the antioxidant enzyme manganese-SOD and the enzymes galactose transferase and glycosyl transferases, which are important for growth and maintenance of connective tissue, cartilage, and bone.
—N-Acetyl L-Cysteine (NAC) (200 mg): An antioxidant that reduces expression of the inflammatory enzyme COX2 and cytokine NFKb
—GlycoMarine™ (Green Lipped Mussel) (100 mg): Protects stomach from NSAID damage. Individuals in GlycoMarine™ studies with joint pain and stiffness responded well to treatment.
—Boswellia (Boswellia serrata)(resin) [standardized for 60% Boswellic Acid] (75 mg): Inhibits lipooxygenase (LOX) enzyme
—Turmeric (Curcuma longa) [standardized to contain 95% Curcuminoids] (75 mg): Inhibits LOX, COX1, COX2, reduces expression of COX2 and iNOS by inhibiting NFKb. Also an antioxidant.
—Cetyl Myristoleate (CMO) (30 mg): Shown to improve knee function in Individuals with osteoarthritis
—Resveratrol (Polygonum cuspidatum) [standardized for 20% Resveratrol] (3 mg): Powerful antioxidant, reduces COX2 enzyme and cytokine NFKb
—Collagen Type II (2 mg): Rats with intestinal lesions had less arthritis symptoms when given Collagen II
Joints, cartilage, ligaments, tendons and synovial fluid (for joint lubrication) undergo a continuous but slow turnover and remodeling process. This is affected by many physiological factors such as diet, supplements, activity, stress, gut health, allergies, immune status, infections, aging, hormones, toxic load and/or various medications. The continuous repair of joints and tissue depend on these nutrients: glucosamine, sulfur (MSM), hyaluronic acid, copper and vitamin C for collagen synthesis (found in tendons, cartilage, ligaments). Exercise should be emphasized because it improves blood and lymph circulation. This enables the nutrients to reach the target tissue more effectively.
Four of the most common destructive processes that can impair the health of the connective tissue are:
Inflammation: This could be caused by excessive joint wear and tear, and/or low body stores of antiinflammatory fatty acids (GLA, EPA) and/or excess of the inflammatory ones (arachidonic acid). Many natural compounds such as turmeric, boswellia, NAC, resveratrol, MSM, green-lipped mussel and cetyl-myristoleate (CMO) have been shown to support this in the positive direction.
Oxidative stress (free radicals generated from various causes including excessive inflammation, infections, poor diet, oxidized fats, toxic metals): Oxidative stress can be significantly reduced by dietary antioxidants such as resveratrol, turmeric, NAC, and by an adequate supply of essential minerals (selenium, copper, manganese, zinc) that support the body's own antioxidant enzymes, such as SOD (superoxide dismutase).
Autoimmune conditions (could be caused by toxic metal/chemical load, intestinal infections, dietary allergies): Most common joint related autoimmune conditions are rheumatoid arthritis and lupus. Various nutrients such as niacinamide, NAC, and type II collagen, all found in ArthroSoothe, have been shown to help.
Catabolic factors: Excessive cortisol production (stress hormones) or steroid treatments such as cortisone can have a devastating effect on the ability to form collagen, which is a major component of cartilage, tendons and ligaments.
Unique Features of ArthroSoothe Ingredients:
New Zealand Green Lipped Mussel (Perna canaliculus). This special extract is standardized for anti-inflammatory activity. (The anti-inflammatory assay used is the same as that for non-steroidal, anti-inflammatory drugs—NSAIDS). This purified mussel extract was shown to suppress carageenan induced edema by 60-70% in a rat paw model and shown to protect the stomach from NSAID damage. [18]
GlycoMarine™ is the only mussel extract product manufactured using a unique and proprietary process characterized by a special extraction of the mussel from the shell and an immediate freeze-drying as the means of preserving and stabilizing the product. Backed by 30 years of independent laboratory research, GlycoMarine™ is the only proven bioactive New Zealand Green Lipped Mussel extract with gastroprotective and chondroprotective qualities.
D-Glucosamine Sulfate Potassium Chloride. Highly purified source of glucosamine sulfate (free of any toxic environmental contaminants), certified by USP assay. It is guaranteed 99% bioactive, unlike others on the market that were found to be as low as 80% bioactive. Glucosamine provides joint building proteoglycans.
CMO—Cetyl Myristoleate 50%. These cetylated fatty acids contain an ester group necessary for their absorption in the gastrointestinal tract. In a research study, Individuals with osteoarthritis given CMO had marked improvement in knee function.
Hyaluronic Acid. The hyaluronic acid used in this formula has a good absorption rate due to a special processing that renders it in a low molecular weight.
Undenatured Collagen Type II—Kolla2™. Type II Collagen is the predominant collagen found in cartilage. Collagen is made up of polypeptide chains of glycine, proline and hydroxyproline mainly. Kolla2™ from chicken sternum contains all the important components of cartilage including collagens, proteoglycans and mucopolysaccharides such as hyaluronic acid and chrondroitin. It is no wonder that chicken soup is a panacea. Kolla2™ is made with a patented processing method that guarantees the preservation of these peptide proteins important for its function. The type II collagen can only exert its immunological effects when its configuration is very well preserved and undenatured during processing. This, in turn, allows the configuration to be recognized by the immune system and lead to downregulation of immune system attack on collagen structures. Extensive research has shown that type II collagen and mucopolysaccharides (such as hyaluronic acid and chondroitin) are lost progressively in rheumatoid and osteoarthritis Individuals. [19-2].
The minerals zinc, copper, and manganese are chelated to amino acids by the patented Albion method. This maximizes their absorption and eliminates the well-known GI side effects of the salt forms of minerals and their interference with absorption of other nutrients ingested at the same time. The reliability of the Albion patented method is proven by strict laboratory testing methods (verified by HPLC).
Selenium is provided as selenomethionine. Methionine is a sulfur containing amino acid. Sulfur is an important component of collagen. Selenium is a protective antioxidant that raises glutathione levels.
The herbal extracts, boswellia and turmeric are standardized for their active ingredients. These herbs have proven in research to reduce inflammation by many mechanisms. These extracts are guaranteed to be free of toxic contaminants, unlike many others on the market, as described in a recent issue of the Lancet Medical Journal. [1]
Many doctors use ArthroSoothe along with fish oils such as OmegaSynergy and SAMe which reduces TNF alpha and increases the number of chondrocytes, the cells that build new cartilage. [14] See Designs for Health's OmegaSynergy and SAMe flyers.
Click here to download ArthroSoothe PDF file
Click here to download ArthroSoothe (Mechanisms of Action) PDF file
- Usha P.R.[1]; Naidu M.U.R.[1]Randomised, Double-Blind, Parallel, Placebo-Controlled Study of Oral Glucosamine, Methylsulfonylmethane and their Combination in Osteoarthritis. Clinical Drug Investigation 2004, vol. 24, no. 6, pp. 353-363(11).
- Surh YJ, Chun KS . Molecular mechanisms underlying chemopreventive activities of anti-inflammatory phyto chemicals: down-regulation of COX-2 and iNOS through suppression of NF-kappa B activation. Mutat Res 2001 Sep 1;480-481:243-68.
- Ammon HP, Safayhi H . Mechanism of antiinflammatory actions of curcumine and boswellic acids. J Ethnopharmacol. 1993 Mar; 38(2-3): 113-9.
- Hesslink R Jr, Armstrong D 3rd. Cetylated fatty acids improve knee function in Individuals with osteoarthritis. J Rheumatol. 2002 Aug;29(8):1708-12.
- Kroger H, Hauschild A . Enhancing the inhibitory effect of nicotinamide upon collagen II induced arthritis in mice using N-acetylcysteine. Inflammation. 1999 Apr;23(2):111-5.
- McCarty MF, Russell AL. Niacinamide therapy for osteoarthritis--does it inhibit nitric oxide synthase induction by interleukin 1 in chondrocytes? Med Hypotheses. 1999 Oct;53(4):350-60.
- Moskowitz RW. Hyaluronic acid supplementation. Curr Rheumatol Rep. 2000 Dec;2(6):466-71.
- Naveh Y, Schapira D . Zinc metabolism in rheumatoid arthritis: plasma and urinary zinc and relationship to disease activity. J Rheumatol. 1997 Apr;24(4):643-6.
- DiSilvestro RA, Marten J . Effects of copper supplementation on ceruloplasmin and copper-zinc superoxide dismutase in free-living rheumatoid arthritis Individuals. J Am Coll Nutr. 1992 Apr;11(2):177-80.
- Shingu M, Takahashi S. Anti-inflammatory effects of recombinant human manganese superoxide dismutase on adjuvant arthritis in rats. Rheumatol Int. 1994;14(2):77-81.
- Bierer TL, Bui LM. Audeval B & Bouchacourt P. Double blind, placebo controlled study of the mussel Perna canaliculus (New Zealand Green-lipped mussel) in gonarthritis (arthritis of the knee). La Gazette References Medicale, 93 (38), 1986.
- Zheng YQ, Wei W . Oral and nasal administration of chicken type II collagen suppresses adjuvant arthritis in rats with intestinal lesions induced by meloxicam. World J Gastroenterol. 2004 Nov 1;10(21):3165-70.
- Saper RB, Kales SN, Paquin J, et al. Heavy metal content of Ayurvedic herbal medicine products. JAMA. December 15, 2004;292(23):2868-2873.
- Glorioso S, Todesco S, Mazzi A, et al. Double-blind multicentre study of the activity of S-adenosylmethionine in hip and knee osteoarthritis. Int J Clin Pharmacol Res 1985;5:39-49.
- Heraud F, Savineau C Copper modulation of extracellular matrix synthesis by human articular chondrocytes. Scand J Rheumatol. 2002;31(5):279-84.
- Miesel R, Kurpisz M . Modulation of inflammatory arthritis by inhibition of poly(ADP ribose) polymerase. Inflammation. 1995 Jun;19(3):379-87.
- Rodriguez JP, Rosselot G. Effects of zinc on cell proliferation and proteoglycan characteristics of epiphyseal chondrocytes. J Cell Biochem. 2001;82(3):501-11.
- Winter CA, Risley EA & Nuss GW, Carrageenin-Induced Oedema in Hind Paw of the Rat as an Assay for Anti-inflammatory Drugs. Proc Soc Exp Biol Med 111:544-547 (1962).
- Hollander, A.Pl, et al, Increased damage to type II collagen in osteoarthritis articular cartilage detected by a new immunoassay. J Clin Invest, 1994.93(4):p. 1722-32.
- Dodge, G., I. Pidoux, and A.R. Poole, The degradation of type II collagen in rheumatoid arthritis: an immunoelectron microscopic study. Matrix, 1991. 11(5) p. 330-8.
- Trentham, D.E., et al., Effects of oral administration of type II collagen on rheumatoid arthritis. Science, 1993. 261(5129) p. 1727-30.
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