Bio-Allergy Plus

Bio-Allergy Plus? is an exciting new nutritional product that can dramatically enhance your allergic individuals joy in life. This formula was developed without the typical sedating or stimulating antihistamine ingredients. In Bio-Allergy Plus?, botanicals and enzymes are used instead. In all allergic processes, tissue anchored white blood cells, known as ?mast cells?, become sensitized and produce inflammatory compounds such as histamines and leukotrienes.

BIO-ALLERGY PLUS is a nutritional product specifically designed to reduce allergic
symptoms without drowsiness, anxiety, insomnia, rapid heart or irregular heart
rate, or benign prostate enlargement.

• Supports healthy sinus and upper respiratory function
• Helps the body reduce sensitivity to food, airborne or contact substances
• Uses botanicals and enzymes without the typical sedating effects of antihistamine ingredients.

Serving size: 2 capsules
Number of servings per container: 45

Amounts per serving:

• Vitamin C (Ascorbyl palmitate).......10 mg.
• Citrus Bioflavonoids.......200 mg.
• Nettle root extract (Urtica dioica).......200 mg.
• Quercetin..........................................150 mg
• Rice bran.......100 mg.
• Turmeric rhizome (Curcuma longa).......80 mg.
• Licorice root extract (Glycyrrhiza glabra)......50 mg.
• Ginger root powder (Zingiber officinalis)(5%
• gingerols).......50 mg.
• Feverfew (Tanacetum parthenium).......100 mg
• Proprietary enzyme blend Bromelain, Lipase, Amylase, Protease, Cellulase..........470mg

OTHER INGREDIENTS: Cellulose, silica.

Suggested Dose:  As a dietary supplement, take 1-2 capsules three times per day or as directed by your healthcare professional.

CITRUS BIOFLAVONOIDS AND NETTLE ROOT (URTICA DIOICA) are examples of two botanicals/plant flavonoids that have been shown to assist in the stabilization of mast cells to help reduce sensitivities to allergenic triggers.

BROMELAIN is a proteolytic enzyme derived from pineapple. It functions as a natural antihistamine and provides both anti-inflammatory and mucolytic properties. The protease activity of bromelain has been shown to be capable of breaking down
and digesting circulating histamine molecules. Its mucolytic activity has been
shown to digest and thin mucous, allowing for proper drainage and clearing of the
airways and the middle ear. BioAllergy Plus also provides additional therapeutic
enzymes to support the activity of bromelain.

RICE BRAN provides a source of sterols/sterolins. The nutrients beta sitosterol and beta sitosterol glucoside have been shown to balance T Helper 1 and T Helper 2 cell function. T cells are often imbalanced in allergy patients due to the excessive
activity of the T Helper 2 cell fraction. Overactivity of T Helper 2 cells leads to
stimulation of excessive antibody production by B lymphocytes/plasma cells as
well as increased output of inflammatory mediators (interleukins, tumor necrosis
factor alpha, etc.).

TURMERIC (CURCUMA LONGA) exhibits direct anti-inflammatory effects by inhibiting leukotriene formation and platelet aggregation while promoting fibrinolysis.

FEVERFEW (TANACETUM PARTHENIUM) inhibits cytotoxic and chemotactic secretion of polymorphonuclear neutrophils. Feverfew also appears to inhibit the production of prostaglandins PGE2, thromboxane, and leukotrienes.

LICORICE (GLYCYRRHIZA GLABRA) has been shown to extend the life of
endogenous cortisol, a major benefit in reducing inflammation. Licorice may
also inhibit prostaglandin synthesis by inhibiting phospholipase A2 and acting
to reduce inflammation.

GINGER (ZINGIBER OFFICINALIS) is thought to inhibit many inflammatory
mediators. Ginger has been used traditionally to support a reduction in painful
and inflammatory conditions.
VITAMIN C (ASCORBYL PALMITATE) has long been used to reduce allergic symptoms. In BioAllergy Plus, ascorbyl palmitate was chosen due to its fat-soluble nature. This allows vitamin C to be retained in the tissues for an extended period of time for enhanced tissue stabilizing and anti-inflammatory properties.

PRECAUTIONS: BioAllergy Plus should not be taken by persons with an active
duodenal or peptic ulcer. BioAllergy Plus should not be consumed if you are
allergic to one or more of its ingredients. Licorice in amounts over 1.5 grams per
day should not be taken by persons with diabetes, glaucoma, heart disorders or
with history of stroke or hypertension.

Citrus bioflavanoids and Urtica dioica are examples of two botanicals/plant flavonoids used to stabilize the mast cell, reducing its sensitivity to allergic triggers.

Bromelain enzyme is another botanical anti-allergic ingredient included. Here we use the most concentrated, undiluted bromelain available. Bromelain performs a number of useful functions. It is a natural anti-histamine. As a proteolytic enzyme it actually digests the histamine molecule. It is anti-inflammatory, and it is a mucolytic. It?s mucolytic actions allow it to digest and thin mucus, so that proper drainage can occur. This is especially important for closed spaces, such as the middle and inner ear, eustachion tubes, sinuses, and airways of the lungs. Additional anti-inflammatory enzymes such as protease, lipase, amylase, and cellulase also support bromelain.

Rice Bran is added to this formula for its sterol/sterolin content. These nutrients based on beta sitosterol and beta sitosterol glucoside act to balance T Helper 1 and T Helper 2 cell function. These T cells are shown to be imbalanced with excessive activity of the T Helper 2 cell fraction in allergy individuals. With overactive T Helper 2 cells the B Lymphocyte/Plasma cells are stimulated into excessive anti-body production. Excessive activity of T Helper 2 cells also leads to excessive inflammatory mediator output (interleukins, tumor necrosis factor alpha, etc.).

Turmeric, Ginger, Licorice, and Feverfew are additional anti-inflammatories also included. These plants have known antioxidant and anti-inflammatory properties.

Curcuma longa (Turmeric) exhibits direct anti-inflammatory effects by inhibiting leukotriene formation, inhibiting platelet aggregation, and promotion of fibrinolysis. Curcumin has been compared to an anti-inflammatory (without the negative side effects), being as effective in acute inflammation and approximately half as effective in chronic inflammation.

Feverfew (Tanacetum parthenium) inhibits cytotoxic and chemotactic secretion of polymorphonuclear neutrophils. Feverfew also appears to inhibit the production of prostaglandins PGE2, thromboxane, and leukotrienes.

Licorice (Glycyrrhiza glabra) through its glycyrrhizin content is capable of extending the life of endogenous cortisol. This is its major benefit in reducing inflammation. Licorice also inhibits prostaglandin synthesis similar to cortisol by inhibiting phospholipase A2 and acting to reduce inflammation.

Zingiber officinale (Ginger) is thought to inhibit many inflammatory mediators (cyclo-oxygenase, leukotrienes, prostaglandins, etc.). Ginger has been used traditionally for inflammatory and painful conditions.

Vitamin C (ascorbyl palmitate) has long been used to reduce allergic symptoms. In BioAllergy?. ascorbyl palmitate was chosen due to its fat-soluble nature. This allows Vitamin C to be retained in the tissues for a longer period of time, thus enhancing its tissue stabilizing and anti-inflammatory properties.

BioAllergy? responds to allergic symptoms without drowsiness, anxiety, insomnia, rapid heart rates, irregular heart rhythm, or benign prostate enlargement. BioAllergy? is a must for your medicine cabinet.

Precautions: BioAllergy? should not be taken by persons with an active duodenal or peptic ulcer. BioAllergy? should not be consumed if you are allergic to one or more of its ingredients. Licorice in amounts over 1.5 g./day should not be taken by persons with diabetes, glaucoma, heart disorders, persons with a history of stroke or high blood pressure.

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2. M et al. Possible involvement of eicosanoids in the pharmacological action of bromalain. Arzneimittelforschung 36:110-12,1986
3. NA and Foreman JC. The activity of compounds extracted from feverfew on histamine release from rat mast cells. J Pharm Pharmacol 39:466-7,1987
4. P. Randomized, double-blind study of freeze-dried Urtica dioica in the treatment of allergic rhinitis. Planta Med 56:44-7, 1990
5. R and Dhawan B. Pharmacology of diferuloyl methane (curcumin), a non-steroidal anti-inflammatory agent. J Pharm Pharmac 25:447-52, 1973
6. M, Bronner C, Briancon F et al. Inhibition of mast cell histamine release by flavonoids and bioflavonoids. Planta Medica 51:16-20, 1985
7. M and Murray M, Botanical Influences on Illness. Tarzana, CA: Third Line Press, 1994