Biotin Forte with Zinc by Integrative Therapeutics

Biotin Forte helps maintain healthy hair, skin, and muscle tissue

Why take a broad-spectrum supplement?

We need these nutrients every day

Biotin is essential to convert carbohydrates to energy, and is involved in the proper metabolism of fats and protein. Plus, adequate biotin levels are needed for healthy nervous system function.
Niacin helps support healthy cholesterol levels already within normal limits, and raises "good" (HDL) cholesterol.
Thiamin supports healthy nerves and muscles, including muscles of the cardiovascular system.

See "More Info" tab to read more...

Supplement Facts
Serving Size: 1 tablet
Servings Per Container: 60 tablets
Amount Per Serving:

Biotin (3000 mcg)........3 mg
Vitamin C (ascorbic acid)........200 mg
Vitamin B-1 (thiamine mononitrate)........10 mg
Vitamin B-2 (riboflavin)........10 mg
Niacinamide........40 mg
Vitamin B-6 (pyridoxine)........25 mg
Folic Acid........800 mcg
Vitamin B-12 (cyanocobalamin)........10 mcg
Pantothenic Acid........10 mg
Zinc (zinc acetate)........30 mg

Other Ingredients: Cellulose, sodium, starch glycolate, silicon dioxide, vegetable stearine, calcium stearate, hydroxpropyl methylcellulose, tilanium dioxide, riboflavin coloring in coating.

Recommended Use:
As a dietary supplement for adults under medical supervision, 1 tablet 1 to 2 times daily or as directed by physician or health care professional. Children, as directed by physician.

Read Customer questions and answers about Zinc Deficiency in our FAQ.

Why take Biotin Forte? with Zinc?

Biotin Forte? with Zinc helps maintain blood pressure levels already within normal limits

B-vitamins convert undesirable homocysteine into methionine, a helpful amino acid that protects cells and supports nerve signals.

Biotin Forte? with Zinc includes vitamin C for extra benefits

B vitamins and vitamin C work together to nourish strong nails, healthy hair, and skin.

Biotin Forte? with Zinc with Zinc provides support for key systems

Zinc supports healthy immune system function, healthy pancreatic insulin production, healthy protein synthesis, and even supports the sense of taste and smell.

Biotin Forte? with Zinc is backed by clinical research

This formula has shown beneficial effects for nervous system and circulatory system health.

Technical Data

How Does It Work?:
While early food scientists considered vitamin B a single vitamin, continued research has demonstrated it to be a complex of chemically distinct vitamins that often coexist in the same foods. As water-soluble vitamins, the B vitamins are crucial to healthy skin and hair. Vitamin C, also water-soluble, is a nutrient closely linked to healthy skin, gum tissues, and teeth.

The following table provides detailed findings on the benefits of each nutrient in Biotin Forte?:

Ingredient	Benefit
Biotin	Biotin is a unique nutrient that plays an important role in human energy. Through the catalyzation of essential enzymes, biotin participates in carbohydrate metabolism, the synthesis of fatty acids, gluconeogenesis, and the transformation of amino acids into proteins.[1] Commonly found in two forms, free biotin and the protein-bound coenzyme form called biocytin, the human body recycles and reuses biotin through a chain of chemical reactions.[2]
Pantothenic acid	Once pantothenic acid is changed to coenzyme A, it helps convert fat, carbohydrate, and protein into energy. Pantothenic acid is also needed to make vitamin D, cholesterol, bile, some fats, red blood cells, hormones and nerve regulators.[3]
Vitamin C (ascorbic acid)	Healthy skin, collagen, connective tissue, bone tissue, and dentin (tooth tissue) formation depend on Vitamin C. As a powerful antioxidant, Vitamin C supports healthy immune system responses.[4-6]
Thiamin (as thiamin HCl)	Also known as Vitamin B1, Thiamin helps support healthy nerves and muscles, including muscles of the cardiovascular system, and healthy metabolism of carbohydrates.[7]
Riboflavin (vitamin B2)	Another member of the B Vitamin family, Riboflavin helps support the healthy metabolism of fats, proteins, and carbohydrates. Riboflavin also supports the health of skin, nails, and hair. [8]
Niacin (as niacinamide)	Niacin helps support healthy cholesterol levels that are already within normal limits and raises beneficial high density lipoprotein (HDL) cholesterol.[9,10]
Vitamin B6 (as pyridoxine HCl)	This water-soluble vitamin supports production of hemoglobin and antibodies. Vitamin B6 also helps support the healthy conversion of stored carbohydrates or other nutrients to glucose to maintain normal blood sugar levels already within normal ranges.[11]
Folic acid	Folic acid has several important functions—it supports the healthy production and maintenance of new cells, supports healthy deoxyribonucleic acid (DNA) replication and ribonucleic acid (RNA) transcription, supports the production of red blood cells, and supports healthy blood sugar and amino acid utilization.[12-15]
Vitamin B12 (as cyanocobalamin)	Well recognized for its support of red blood cell production, Vitamin B12 also supports nervous system function. Up to 30% of people over age 50 have reduced ability to absorb adequate vitamin B12 from meat or dairy products.[16]
Zinc (as zinc sulfate)	Involved in more than 100 enzymatic actions and re-actions, Zinc is crucial to human health. Zinc supports healthy immune system function, healthy pancreatic insulin production, healthy protein synthesis, helps support the sense of taste and smell, and supports healthy DNA synthesis.[17]

The Biotin Cycle
The biotin cycle is a chain of chemical reactions involved in the use and reuse of the vitamin. In the presence of the enzyme biotinidase, bound biotin is separated from protein to become free biotin, the form used by the body. Biotinidase allows the body to recycle and reuse biotin over and over again. Many researchers attribute biotin's ability to support the health of skin and hair to this unique cyclic activity.[2]

Additional Health Support
Biotin Forte has been clinically studied for its beneficial effects on nervous system and circulatory system health.[18]

The nutrients in Biotin Forte play other vital health supportive roles as well. Vitamin C is a highly effective antioxidant. Even in small amounts vitamin C protects indispensable molecules in proteins, lipids, carbohydrates, and deoxyribonucleic acid (DNA), from free radical damage. Vitamin C also prevents damage to cells resulting from environmental or dietary sources, such as ozone and nitrous oxide (primarily from automobile exhaust), heavy metals (such as mercury, cadmium, and lead), saturated fat, and other chemicals and compounds from food, water, and air.[5,6,17]

Folic acid, vitamin B6, and vitamin B12 play key roles in recycling homocysteine, a sulfur-containing amino acid into methionine, another amino acid. Methionine is required for the synthesis of S-adenosylmethionine (SAMe), a compound involved in the support of cell membranes and the production of healthy neurotransmitters.[19,20]

Conclusion
Integrative Therapeutic's Biotin Forte? is a nutritional supplement that has been formulated from the findings of clinical trials and laboratory research. The weight of the evidence has demonstrated that the nutrients in Biotin Forte provide superior nutritional support for healthy skin, collagen, and hair.

Precautions:
If pregnant, nursing, or taking prescription drugs, consult your healthcare practitioner prior to use.

Fleming T., ed. Biotin. In: PDR? for Nutritional Supplements. Montvale, NJ: Medical Economics Company; 2001: 50-55.

Grodner M, Anderson SL, DeYoung S. Biotin. In: Foundations and Clinical Applications of Nutrition: A Nursing Approach. St. Louis, Mo: Mosby;124.

Fleming T., ed. Pantothenic acid. In: PDR? for Nutritional Supplements. Montvale, NJ: Medical Economics Company; 2001: 341-346.

Dakhale GN, Khanzode SD, Khanzode SS, Saoji A. Supplementation of vitamin C with atypical antipsychotics reduces oxidative stress and improves the outcome of schizophrenia. Psychopharmacology. 2005;182:494-8.

Goldfarb AH, Patrick SW, Bryer S, You T. Vitamin C supplementation affects oxidative-stress blood markers in response to a 30-minute run at 75% VO2max. Int J Sport Nutr Exerc Metab. 2005;15:279-90.

Harreus U, Baumeister P, Zieger S, Matthias C. The influence of high doses of vitamin C and zinc on oxidative DNA damage. Anticancer Res. 2005;25:3197-201.

Fleming T., ed. Thiamin. In: PDR? for Nutritional Supplements. Montvale, NJ: Medical Economics Company; 2001: 441-445.

Grodner M, Anderson SL, DeYoung S. Riboflavin. In: Foundations and Clinical Applications of Nutrition: A Nursing Approach. St. Louis, Mo: Mosby; 2000:.45.

Lin TH, Voon WC, Yen HW, Huang CH, Su HM, Lai WT, Sheu SH. Randomized comparative study of the effects of treatment with once-daily, niacin extended-release/lovastatin and with simvastatin on lipid profile and fibrinolytic parameters in Taiwan. Kaohsiung J Med Sci. 2006;22:257-65.

Pins JJ, Keenan JM. Dietary and nutraceutical options for managing the hypertriglyceridemic patient. Prog Cardiovasc Nurs. 2006;21:89-93.

Fleming T., ed. Vitamin B6. In: PDR? for Nutritional Supplements. Montvale, NJ: Medical Economics Company; 2001: 469-476.

van Ede AE, Laan RF, Rood MJ, et al. Effect of folic or folinic acid supplementation on the toxicity and efficacy of methotrexate in rheumatoid arthritis: a forty-eight week, multicenter, randomized, double-blind, placebo-controlled study. Arthritis Rheum. 2001;44:1515-24.

Malouf R, Grimley Evans J. The effect of vitamin B6 on cognition. Cochrane Database Syst Rev. 2003;(4):CD004393.

Brouwer IA, van Dusseldorp M, Thomas CMG, et al. Low-Dose folic acid supplementation decreases plasma homocysteine concentrations: a randomized trial. Indian Heart J. 2000;52:S53-58.

Rydlewicz A, Simpson JA, Taylor RJ, Bond CM, Golden MH. The effect of folic acid supplementation on plasma homocysteine in an elderly population. QJM. 2002;95:27-35.

Toohey JI. Vitamin B12 and methionine synthesis: a critical review. Is nature's most beautiful cofactor misunderstood? Biofactors. 2006;26:45-57.

Wintergerst ES, Maggini S, Hornig DH. Immune-enhancing role of vitamin C and zinc and effect on clinical conditions. Ann Nutr Metab. 2006;50:85-94.

Jones WO, Nidus BD, Matalon R, Katz LA. Biotin may relieve intractable hiccups in dialysis patients. National Kidney Foundation Annual Scientific Meeting. 1987.

McCarty MF. Hepatothermic therapy of obesity: rationale and an inventory of resources. Med Hypotheses. 2001;57:324-36.

Depeint F, Bruce WR, Shangari N, Mehta R, O'brien PJ. Mitochondrial function and toxicity: Role of the B vitamin family on mitochondrial energy metabolism. Chem Biol Interact. 2006 May 1; [Epub ahead of print]