Brain Vibrance Supreme Powder by Crayhon Research 

Brain Vibrance Supreme is an excellent way to get the exact doses used in human clinical research for three most important nutrients that support brain function. Two teaspoons of Brain Vibrance Supreme powder supply 1500 mg elemental Acetyl-L-Carnitine, 1200 mg elemental GPC, and 300 mg elemental Phosphatidyl Serine—precisely the same doses used in numerous human clinical trials. No other product gives you these exactly correct doses in only two servings. Magnesium is added to balance the calcium that is present in GPC powder.

Benefits:

• Stroke recovery
• Brain health
• Attention & mental focus
• Mental performance
• Mood control (anxiety, stress)
• Memory difficulties
• Spreading cognitive impairment
• Brain repair
• Sociability / Activities of daily living 

Read Customer questions and answers about Brain Wellness in our FAQ.

Click Here to read Dr. Parris Kidd's research summary on the benefits of GPC for brain health

Click Here to read a printable 4 page .pdf product flyer by Parris Kidd, PhD

The human brain is a metabolic dynamo that weighs a mere 3 pounds yet demands at least one-fifth of our oxygen and blood sugar even when at rest. To support this intense activity it also requires the full spectrum of nutrients. Three nutrients stand out from the rest for their proven clinical benefits, their safety of use, and their contributions to brain vitality and renewal.

The Three Most Proven Brain Nutrients: PS, GPC, AC
The peer-reviewed scientific literature on 3 brain nutrients has elevated them above the rest. These are PS (phosphatidylserine),GPC (glycerophosphocholine), and AC (acetylcarnitine). Think of them as the Big 3 nutrients for brain vitality and repair. The Big 3 brain nutrients all are orthomolecules, molecules orthodox to the body, as first recognized by Professor Linus Pauling, Nobel Laureate in Chemistry. Being orthomolecular means these nutrients occur naturally in all our cells and are deeply rooted in our life processes. This fundamental role in nutrition translates not just into exceptional efficacy, but also into exceptional safety since our cells are literally built on these molecules.

The Big 3 brain nutrients are all very well absorbed, and have numerous action mechanisms that overlap to reinforce each other’s effects on cognition, mood, and mental endurance. PS, Brain Booster for Memory, Cognition, Mood, Stress PS (phosphatidylserine, pronounced fos-fa-tie-dil-ser-een) is a phospholipid nutrient and cell membrane building block. Cells function on their membranes, and within the membrane PS enwraps important proteins to create an appropriate “microenvironment” for each to function. The findings from some 22 double-blind clinical trials conducted with PS indicate diverse and marked benefits for the brain. The author’s book PS (PhosphatidylSerine), Brain Booster for Memory, Mood and Stress, details the many benefits of PS for people of all ages.

The 1991 US double-blind trial conducted on PS by Crook and his associates was a breakthrough (see References). This internationally renowned research team recruited subjects over 50 years of age who were clinically healthy, yet had measurable impairment of their memory and other cognitive functions. They gave the patients PS at 300 mg per day for 3 months. Out of this well designed trial came data that indicated PS could restore several years’ worth of functional mental performance. The US FDA was sufficiently impressed by the research to allow two qualified health claims for PS: one for dementia and one for cognitive dysfunction in the elderly.

For subjects with severe cognitive difficulties, PS used by itself is not a panacea. But multiple double-blinded trials suggest PS often improves quality of life, sociability (willingness to interact with others), and “activities of daily living” such as personal grooming and self-feeding. PS also often improves mood, ability to cope with anxiety, and hormonal rhythms based in the pituitary. Brain imaging shows that PS can enhance energy production in the brain. PS also helps young, healthy individuals. In several double-blind trials with subjects under 30 years of age, PS down-regulated blood cortisol levels while improving mental or physical performance under stress.

GPC, Mind-Body Nutrient for Active Living and Healthy Aging
GPC (glycerophosphocholine, pronounced gli-sero-fos-fo-ko-lean) is (like PS) also a phospholipid nutrient with marked clinical benefits. But GPC exists in a different cellular subworld than does PS. While PS is found solely within cell membranes, GPC is a water-phase (cytoplasmic) phospholipid. As the water phase is much larger in volume than the membrane phase, GPC can build up to very high levels in our cells. Attaining these routine high levels gives GPC the power to play many important roles in human brain tissue.

GPC is a highly protective nutrient, including being a rare osmotic regulator and urea buffer. This chemical property alone makes GPC valuable for the brain, as it is for the kidneys and other organs. GPC is one of a few nutrients that can be used to regulate or fine-tune osmotic forces that could tear the cell apart. Also, GPC is perhaps the only nutrient that can effectively keep urea from damaging cells.

GPC is a reservoir for the essential nutrient choline. GPC has choline as part of its molecular structure, easily pulled away by enzymes that use very little energy. Choline is very important for brain development and maintenance, so much so that human mother’s milk contains substantial amounts of GPC as its readily available choline source. The GPC in mother’s milk also is an energy-effective starting source for the phospholipids necessary for cell membrane expansion and cell proliferation.

When used as a dietary supplement, GPC readily elevates choline levels in the brain. Choline building up in the brain from GPC can also boost acetylcholine synthesis, with the acetyl group coming (partly, at least) from acetylcarnitine. The author’s book GPC (GlyceroPhosphoCholine), Mind Body Power for Active Living and Healthy Aging, gives the full story on GPC and its remarkable benefits for stroke and brain injury as well as for cognition and mental endurance.

AC (Acetylcarnitine) for Energy and Mitochondrial Performance
AC (acetylcarnitine) is the third blockbuster brain nutrient in Brain Vibrance SupremeTM Powder. This is a nutrient essential for making energy, without which the brain could not get anything done. Abundant life energy is crucial in order for PS and GPC to have their revitalizing effects in fatigued brain cells and circuits.

AC has at least two major modes of action. One is to help transport fatty acids into the mitochondria, the energy factories of our cells. These are then used to make ATP, the chemical “energy currency” of life. Here AC biochemically overlaps with PS, which helps support the mitochondrial membranes.

The other main function of AC is to provide acetyl groups, which are used to regulate many metabolic pathways. Acetyl groups drawn from AC also go to make acetylcholine, a chemical transmitter that operates between nerve cells inside and outside the brain. Acetylcholine also powers the nerve-muscle junctions that trigger voluntary muscle contraction. Further, this ubiquitous messenger also underlies the activity of the autonomic nervous system as it regulates our unconscious functions.

There are some 21 double-blind trials on AC for brain and other nervous system applications. The myriad positive effects of AC prove that just by energizing its cells, a chain of positive processes are set in motion that can result in brain repair and regeneration. Altogether, the brain benefits of these Big 3 brain nutrients have been explored in more than 60 published randomized controlled trials, hundreds of other human studies,and thousands of experimental studies. They are a mutually supportive triad of nutrients, with diverse action mechanisms that support nerve networks throughout the body, and with excellent safety and tolerability due mainly to their orthomolecular nature.

The Big 3 Nutrients Help the Human Brain Repair Itself
Until very recently the human brain was thought incapable of any substantial self-repair once damaged. Until stem cells were discovered in the brain, that is. Now it is clear that our brains are actually quite plastic—capable of making new circuits if provided with the necessary cofactors for the task. S

tem cells make it possible for the brain to make new cells that then become functional as new circuits. Previously the human brain was assumed to lack stem cells. But just in the 1990’s decade stem cells were found in the hippocampus (the major zone for initiating new memories), in the cortex, and other brain zones.

Experiments with rats, mice, and monkeys have demonstrated that under suitable conditions, stem cells can become active and make new circuits in the working brain. In animal models of stroke, for example, new nerve cell formation, new circulation, and a degree of structural and functional recovery are seen in the damage zone.

One important condition for making new brain circuits from stem cells is sensory stimulation. Another is the presence of adequate levels of growth factors. These are a class of small protein messenger substances, naturally produced and released in every healthy tissue. The quality and quantity of stimuli reaching the brain affect growth factor status, which in turn affects stem cell activity.

Nerve growth factor or NGF was the first growth factor to be discovered. Clinical researchers at the University of California at San Diego did a small clinical trial (“Phase I”) that probed the importance of NGF in the human brain. The outcome was reported in Nature Medicine in 2005 (volume 11, pages 551-5). When NGF release was upregulated in one brain zone, new circuits formed. Functional imaging revealed that these brains made more energy, and that the progression of early Alzheimer’s was slowed (see Fig.1).

The enhancement of NGF levels through this high-tech intervention had fostered new brain circuits, improved energetics in the brain, and partially slowed the dementia progression. But such radical steps may not be necessary—the Big 3 brain nutrients all enhance natural NGF action in the brain, and are the only agents so far proven to have this effect. Fig. 2 illustrates the conservation of NGF receptor action in the aging rat brain by PS. GPC and AC have shown similar effects.

Commonly Asked Questions About Brain Vibrance Supreme Powder
Q. When will I start feeling the benefits of this dietary supplement?
A. We expect many people will begin noticing improvement
after 1-3 weeks, and that their improvement will progress over
months as they continue to take the product.

Q. Are any of these nutrients allergenic?
A. PS and GPC are initially made from soy lecithin, but
are highly purified and contain no allergenic soy residuals
whasoever. As with all other Crayhon products, this formulation
has no hidden additives and was designed to be hypoallergenic.

Q. Why take this supplement in the morning?
A. The potent orthomolecules in Brain Vibrance Supreme
Powder can be highly energizing for the brain. Taking it later in
the day could keep the mind active past bedtime.

Q. How does this product compare with other Crayhon brain products?
A. Individuals seeking the most optimal long-term brain
benefits should consider taking PS/Omega-3 SynergyTM in
conjunction with this product. Both are designed to be taken along
with Crayhon’s Body VibranceTM multivitamin mineral supplement.

Q. What are the highest safe intakes of these various brain nutrients?
A. Proven safe maximum intakes of these various brain
nutrients for adults are (per day): PS 500 mg, GPC 1.2
grams, AC 3 grams. The total (DHA+EPA) obtained from
PS/Omega-3 SynergyTM is comfortably safe up to 2 grams
per day (4 softgels).