Other Ingredients: Cellulose, silica, stearic acid.
Suggested Use: As a dietary supplement, take 1-2 capsules per day or as directed by your healthcare professional.
Coleus forskohli and these medication contraindications:
ANTICOAGULANT/ANTIPLATELET DRUGS: Theoretically, concomitant use of forskolin and anticoagulant or antiplatelet agents might increase the risk of bruising and bleeding. There is some evidence forskolin can inhibit platelet aggregation and adhesion. Some anticoagulant and antiplatelet drugs include abciximab (ReoPro), anagrelide (Agrylin), antithrombin III (Thrombate III), ardeparin (Normiflo), cilostazol (Pletal), clopidogrel (Plavix), dalteparin (Fragmin), danaparoid (Orgaran), dicumarol, dipyridamole (Persantine), enoxaparin (Lovenox), eptifibatide (Integrilin), heparin, lepirudin (Refludan), tirofiban (Aggrastat), and warfarin (Coumadin). CALCIUM CHANNEL BLOCKERS: Using forskolin with calcium channel blockers such as verapamil (Calan, Covera-HS, Verelan), nifedipine (Procardia), and diltiazem (Cardizem, Dilacor, Tiazac) might cause additive coronary vasodilatory effects. NITRATES: Using forskolin with nitrates such as nitroglycerin (Nitro-Bid, Nitro-Dur, Nitrostat) and isosorbide (Imdur, Isordil, Sorbitrate) might cause additive coronary vasodilatory effects.
SURGERY: Forskolin has antiplatelet effects. Forskolin might cause excessive bleeding if used perioperatively. Discontinue forskolin at least 2 weeks before elective surgical procedures.
Read Customer questions and answers about High Blood Pressure in our FAQ.
Terminalia Arjuna is the herb of choice in Ayurvedic medicine for cardiovascular health. Arjuna supports healthy heart function, lipid metabolism, has antioxidant properties and promotes healthy prostaglandin levels. Its principal constituents are: á sitosterol, ellagic acid and arjunic acid.
Tribulus Terrestris has been used traditionally for fluid retention, as an antiseptic and anti-inflammatory. Additional uses have been to support liver, kidney and cardiovascular health. Current use is often for support of sexual function and fertility. Tribulus has smooth muscle relaxant properties, which explain its benefit on sexual function and its blood pressure regulating properties.
Cordyceps Sinensis and Shark Cartilage are combined in Cardio HTN to support the healthy regulation of PHF (Parathyroid Hypertensive Factor). Healthy PHF levels support healthy intracellular calcium levels, which supports healthy blood pressure.
Rauwolfia Serpentina contains the alkaloid, reserpine. Rauwolfia has been shown to be an effective blood pressure lowering agent. Rauwolfias alkaloids relax the nervous system by reduction of sympathetic dominance. This effect is mediated by removal of noradrenaline and prevention of reabsorbtion at the noradrenergic nerve ending. Rauwolfia may have selective noradrenaline reuptake inhibitor properties.
When given in small quantities the main effect is relaxation of the mind and blood vessel tone. Large doses (several grams) may promote depression. No health hazards are known in conjunction with the proper administration of designated therapeutic dosages.
Inula Racemosa has its traditional use in Ayurvedic medicine for the support of healthy blood pressure, cardiovascular health, liver and respiratory health.
Coleus Forskohlii contains a diterpene molecule known as forskolin, which is a powerful activator of adenylate cyclase which leads to elevation of cAMP. In the artery, this effect promotes relaxation of the arterial wall and a reduction of blood pressure.
Magnesium has potent vasodilator properties and has the ability to displace calcium from the smooth muscle cell surfaces. With magnesium deficiency there is an increased flow of calcium into vascular smooth muscle cells, increasing contractility and potentiated constrictor effects.
Bhatia J, Bhattacharya SK, Mahajan P, Dwivedi S. Effect of Terminalia Arjuna on coronary flow, an experimental study. Indian Journal of Pharmacology. 30(2): p118-119, 1998 (Eng).
Dubey MP et al. Pharmacological studies on coleonol, a hypotensive diterpene from Coleus forskohlii. J Ethnopharmacol. 3:1-13, 1981.
Lindner E, Dohadwalla AN, Bhattacharya BK. Positive inotropic and blood pressure lowering activity of a diterpene derivative from Coleus forskohlii: Forskolin. Arnzneim Forsch 28(2):284-9, 1978.
Fraser HS. Reserpine: A tragic victim of myths, marketing, and fashionable prescribing. Clin Pharmacol Therapeutics 60:368-73, 1996.