Chromium Synergy

Designs for Healths Chromium Synergy offers the best chelated minerals sourced from the worlds leader in chelated mineral science, Albion Advanced Nutrition. The chromium in Chromium Synergy is fully chelated to glycine and nicotinate for enhanced absorption. All the nutrients in this formula play different important roles in insulin function. It is in a base of cinnamon powder also known for its ability to assist blood sugar control. Ask for our two page flyer which includes an abstract comparing chromium picolinate to chromium nicotinate, showing enhanced absorption of chromium nicotinate.

What are true chelates?
For minerals to properly form coordinate covalent bonds with the amino groups of amino acids, they must be mixed in liquid solution. These bonds cannot form in a dry environment by simply mixing ingredients together in powdered form. True chelates need to be small enough in molecular weight to be absorbed by the body (not more than 800 daltons). True chelates are absorbed better than mineral salts and are better retained in body tissue. Chelates are better tolerated than non-bound mineral salts. Since they are better tolerated and absorbed they are less likely to cause loose stools or other gastrointestinal discomfort.

The ligands the minerals are chelated to are important as the chelated compound will remain chelated throughout the gut and into the bloodstream. Mineral salts from non-true chelates break apart far sooner, usually in the stomach, leaving the body with the extra compound to deal with and the mineral in ionic form. Ionic minerals can interfere with the absorption of other minerals such as iron and zinc whereas chelated minerals do not. Albion minerals are mainly chelated with the amino acid glycine due to its low molecular weight. Glycine is very safe, even in high doses. It helps to slow the degeneration of muscle tissue as it helps to synthesize creatine. Glycine is involved in energy production, formation of amino acids for the immune system, CNS function, liver detoxification, and prostate health.

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Serving Size:
Servings Per Container:  

Amount per Serving:

• Vitamin D (as Cholecalciferol) 100 IU
• Zinc (TRAACS Zinc Glycinate Chelate) 10 mg
• Manganese (TRAACS Manganese Glycinate Chelate) 1 mg
• Chromium (TRAACS Chromium Nicotinate Glycinate Chelate) 300 mcg
• Taurine 500 mg
• Vanadium (TRAACS Vanadium Nicotinate Glycinate Chelate) 100 mcg

Inactive Ingredients: Microcrystaliine cellulose, cinnamon powder, magnesium stearate.

Recommended Dosage:
As a dietary supplement, take one to three capsules per day with meals or as directed by your health care practitioner.

This product does not contain: wheat, yeast, soy, gluten, eggs, dairy, corn, artificial colors, flavors, sugars, or preservatives.

Read customer questions and answers about Digestive Health on our blog.

Chromium is Useful in the Treatment of:

• Insulin Resistance
• Diabetes
• Obesity
• Sugar Cravings
• Hypoglycemia
• Stroke
• High Blood Pressure
• Crohn's disease
• Colitis
• Ulcers
• Gastritis
• Multiple Sclerosis
• Migraines
• PMS tension
• Acne
• Some Psychiatric Disturbances

Clinical Applications of Chromium Synergy:

• Blood sugar control 1 capsule with each meal and snack
• Lower cholesterol 1-2 capsules daily
• Diabetes Type II (Adult Onset) 2 capsules with breakfast and dinner, 1 capsule with lunch.

Will Chromium Synergy help balance my blood sugar?
Yes! It is critical that you supplement with Chromium Synergy in addition to making changes in your eating habits. First and foremost, you must avoid consumption of refined non-fiberous carbohydrates such as sugar and bread. This will allow your body to naturally improve its blood sugar control. In addition, you need to add Chromium Synergy to give your body optimal amounts of the nutrients it needs to regulate blood sugar response. Within the first week, you will notice less fatigue after meals, less irritability between meals, and better mental focus!

Are there any nutrients that help Chromium work more effectively?
Lipoic Acid, Zinc, magnesium, taurine, vitamin E, manganese, EPA, and flaxseed oil all increase the effectiveness of chromium. Many ingredients are already found in Chromium Synergy! Diabetics and those with moderate to severe blood sugar issues should add Lipoic Acid to their supplement programs in the dose of 300mg per day.

Diabetes
Chromium works with insulin to help sugar from your blood enter the tissues and cells for energy. This mineral is so important in sugar tolerance that severe deficiencies of it cause a diabetes-like illness to develop. [15]

Chromium deficiency during pregnancy
Chromium deficiency during pregnancy may explain the diabetes that develops during pregnancy, also known as Preeclampsia. This deficiency coupled with insulin?s actions may also contribute to the rapid weight gain, fluid retention, and rise in blood pressure some women experience during pregnancy and afterward.[15]

Atherosclerosis
Chromium is used to help reduce atherosclerosis. Cultures with higher tissue levels of chromium appear to have lower incidences of atherosclerosis and heart disease.[16]

What Chromium Synergy Gives You

• 300mcg of Chromium?a full 300mcg of chromium per capsule for its well-documented benefits on blood sugar and insulin action.[1,2] Chromium supplementation is a must for older patients, as chromium levels decline with age.[3]
• Zinc?a trace mineral needed for healthy blood sugar and insulin metabolism. Diabetics are often zinc deficient [4,5] and zinc is an essential nutrient needed for the synthesis, storage, secretion, and conformational integrity of insulin.[6]
• Manganese?for its benefits on insulin metabolism [7,8]
• Taurine?for its insulin-potentiating action [9,10]
• Vitamin D?for its insulin and blood sugar supporting benefits [11,12]
• Vanadium?in a safe, physiologic dose, for its proven benefits on blood sugar metabolism [13]
• Cinnamon?for its chalcone polymers which have been found to benefit insulin and blood sugar metabolism14

Click here to download Chromium Synergy PDF file: Healthy Blood Sugar and Insulin Metabolism Research

Research Review:

Chromium Synergy is improved and now offers the best chelated minerals available, from Albion Advanced Nutrition, yet still at the same low price. The chromium in Chromium Synergy is now fully chelated to glycine and nicotinic acid for enhanced absorption. All the nutrients in this formula play different important roles in insulin function. It is still in a base of cinnamon powder, also known for its ability to assist blood sugar control.

WHAT ARE TRUE CHELATES?
For minerals to properly form coordinate covalent bonds with the amino groups of amino acids, they must be mixed in liquid solution. These bonds cannot form in a dry environment by simply mixing ingredients together in powdered form. True chelates need to be small enough in molecular weight to be absorbed by the body (not more than 800 daltons). True chelates are absorbed better than mineral salts and are better retained in body tissue. Chelates are better tolerated than non-bound mineral salts. Since they are better tolerated and absorbed they are less likely to cause loose stools or other gastrointestinal discomfort.

The ligands that the minerals are chelated to are important, as the chelated compound will remain chelated throughout the gut and into the bloodstream. Mineral salts from non-true chelates break apart far sooner, usually in the stomach, leaving the body with the extra compound to deal with and the mineral in ionic form. Ionic minerals can interfere with the absorption of other minerals such as iron and zinc whereas chelated minerals do not. Albion minerals are mainly chelated with the amino acid glycine due to its low molecular weight. Glycine is very safe, even in high doses. It helps to slow the degeneration of muscle tissue by helping to synthesize creatine. Glycine is involved in energy production, formation of amino acids for the immune system, CNS function, and prostate health. Studies show some other great benefits of glycine including accelerating recovery from alcohol-induced liver injury.(1)

Reference
1. Yin et al. Glycine accelerates recovery from alcohol-induced liver injury. J Pharmacol Exp Ther, Aug. 1998. 286(2):1014-9

CHROMIUM NICOTINATE IS SAFER THAN CHROMIUM PICOLINATE

Cytotoxicity and oxidative mechanisms of different forms of chromium.
Toxicology. 2002 Oct 30;180(1):5-22.
Bagchi D, Stohs SJ, Downs BW, Bagchi M, Preuss HG.

Department of Pharmacy Sciences, Creighton University School of Pharmacy and Health Professions, 2500 California Plaza, Omaha, NE 68178, USA. debsis@creighton.edu

Chromium exists mostly in two valence states in nature: hexavalent chromium [chromium(VI)] and trivalent chromium [chromium(III)]. Chromium(VI) is commonly used in industrial chrome plating, welding, painting, metal finishes, steel manufacturing, alloy, cast iron and wood treatment, and is a proven toxin, mutagen and carcinogen. The mechanistic cytotoxicity of chromium (VI) is not completely understood, however, a large number of studies demonstrated that chromium(VI) induces oxidative stress, DNA damage, apoptotic cell death and altered gene expression. Conversely, chromium(III) is essential for proper insulin function and is required for normal protein, fat and carbohydrate metabolism, and is acknowledged as a dietary supplement. In this paper, comparative concentration- and time-dependent effects of chromium(VI) and chromium(III) were demonstrated on increased production of reactive oxygen species (ROS) and lipid peroxidation, enhanced excretion of urinary lipid metabolites, DNA fragmentation and apoptotic cell death in both in vitro and in vivo models. Chromium(VI) demonstrated significantly higher toxicity as compared with chromium(III). To evaluate the role of p53 gene, the dose-dependent effects of chromium(VI) were assessed in female C57BL/6Ntac and p53-deficient C57BL/6TSG p53 mice on enhanced production of ROS, lipid peroxidation and DNA fragmentation in hepatic and brain tissues. Chromium(VI) induced more pronounced oxidative damage in multiple target organs in p53 deficient mice. Comparative studies of chromium(III) picolinate and niacin-bound chromium(III), two popular dietary supplements, reveal that chromium(III) picolinate produces significantly more oxidative stress and DNA damage. Studies have implicated the toxicity of chromium picolinate in renal impairment, skin blisters and pustules, anemia, hemolysis, tissue edema, liver dysfunction, neuronal cell injury, impaired cognitive, perceptual and motor activity, enhanced production of hydroxyl radicals, chromosomal aberration, depletion of antioxidant enzymes, and DNA damage. Recently, chromium picolinate has been shown to be mutagenic and picolinic acid moiety appears to be responsible as studies show that picolinic acid alone is clastogenic. Niacin-bound chromium(III) has been demonstrated to be more bioavailable and efficacious and no toxicity has been reported. In summary, these studies demonstrate that a cascade of cellular events including oxidative stress, genomic DNA damage and modulation of apoptotic regulatory gene p53 are involved in chromium(VI)-induced toxicity and carcinogenesis. The safety of chromium(III) is largely dependent on the ligand, and adequate clinical studies are warranted to demonstrate the safety and efficacy of chromium(III) for human consumption.