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CircuPower by Crayhon Research

30 capsules
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March 28, 2013- Please note that this item is on vendor backorder with an unknown restock date. Please check back.
Natural Support for Healthy Circulation

CircuPower is an exciting new herbal vein support formula which has been used for over three decades in Europe and which is supported by forty human clinical trials. CircuPower has been found to naturally support circulation, vein health and capillary integrity in such conditions as varicose veins, lymphedema, hemorrhoids, chronic venous insufficiency, and diabetes. CircuPower also boasts natural anti-inflammatory and free-radical scavenging effects.

Supplement Facts
Serving Size:  1 capsule
Servings Per Container:  30

Amount Per Serving:

  • DiosVein Diosmin.......450 mg
  • Hesperidin.......50 mg

    Other Ingredients:  Gelatin, silicon dioxide, magnesium stearate, microcrystalline cellulose.

    Recommended Use:
    As a dietary supplement, take one capsule per day or as directed by your healthcare practitioner.

    This product does not contain wheat, yeast, soy, dairy, artificial colors or flavors.

  • Read Customer questions and answers about Other Health Concerns in our FAQ.

    CircuPower is a combination of two natural plant flavonoids extracted from citrus, Diosmin and Hesperidin. This combination of these two flavonoids has been studied in over forty human clinical trials and has been found to naturally support vein health, hemorrhoids, diabetic complications, and lymphedema. It has also been found useful in the management of diabetes and PMS. Diosmin has also been found safe and effective even in pregnancy.

    Varicose Veins and Chronic Venous Insufficiency (CVI)
    Varicose veins are veins that have become enlarged and twisted, and are usually found in the lower part of the legs, although varicose veins may occur in other areas of the body as well. Veins have leaflet valves to prevent blood from flowing backwards. Leg muscles pump the veins to return blood to the heart. When veins become enlarged, the leaflets of the valves no longer meet properly, and the valves don't work. This condition is also known as chronic venous insufficiency (CVI). Numerous studies show that Diosmin helps reduce the symptoms associated with varicose veins, and accomplishes much of the benefit through its natural anti-inflammatory and vasodilatory actions. In 30 cases studied, Diosmin demonstrated positive effect on CVI symptoms, reducing edema and other symptoms. Additional research in 200 patients has replicated these results.Researchers suggest that Diosmin is helpful even in the most severe stages of CVI.

    Venous Leg Ulcers
    The clinical efficacy of Diosmin in venous leg ulcers has been demonstrated by several randomized controlled studies, in which the rate of ulcer healing was significantly accelerated.6 A meta-analysis of five large European studies on Diosmin administration to 723 patients with venous trophic ulcers displayed that Diosmin has a statistically significant clinical effect on middle-sized trophic ulcers that persist for 6 to 12 months.7

    Chronic Venous Diseases
    Diosmin can also help in the natural support of chronic venous disease (CVD). Leg heaviness, discomfort, itching, cramps, pain, paresthesia, and edema are the most frequent manifestations of CVD and a major reason for seeking medical attention. Research conducted in 5,052 patients in 23 countries using a visual analog scale for evaluating pain, leg heaviness, cramps, and a sensation of swelling, showed that Diosmin led to clinical improvement in as little as 2 months. Quality of life for patients also increased dramatically, and swelling in lower limbs decreased significantly.

    Supporting Vein Health and Healing After Phlebectomy
    Diosmin also supports vein health and wellness when superficial varicose veins are surgically removed, a procedure known as a phlebectomy, according to a study of 245 patients. In a study of 200 patients receiving 1,000 mg of Diosmin per day for 2 weeks before and 30 days after the operation, Diosmin helped to attenuate pain syndrome, decrease postoperative hematomas and accelerate their resorption, and to increase exercise tolerance in early postoperative period.

    Pelvic Congestion Syndrome
    Chronic pelvic pain or Pelvic Congestion Syndrome is a fairly common condition among females. More than 30% of women complain about pain in the lower abdomen at some point in their lifetime. It is believed that this condition is associated with varicose veins in the lower abdomen and groin. The varicose veins develop during pregnancy and continue to progress in size. Twenty women aged 28-35 yrs with chronic pelvic pain received 500 mg of Diosmin twice a day for 6 months, while 10 received a placebo. They were crossed over for another 6 months. At the end of the third month, the frequency and severity of pelvic symptoms began to decrease in the Diosmin group, but not in those taking the placebo. Thus, Diosmin may help optimize pelvic circulation and relieve pelvic symptomatology.

    Diosmin has also been found helpful in the natural management of hemorrhoids.11 Two thousand milligrams used for 4 weeks resulted in a statistically significant improvement in all hemorrhoidal symptoms, including pain, heaviness, bleeding, and pruritus, all without any significant side effects. Further research has confirmed these benefits.Diosmin has also been found safe and effective in the treatment of hemorrhoids during pregnancy.

    Supporting circulatory health is an important strategy for maintaining the health of diabetics. Three thousand milligrams per day of Diosmin given for 4 weeks decreased red blood cell aggregation and resulting ischemia.Markers of glycation such as hemoglobin A1C also decreased with Diosmin supplementation, and levels of the antioxidant enzyme glutathione peroxidase rose.The idiopathic edema often seen with diabetes is also reduced with Diosmin.Diosmin also supports and normalizes capillary function in diabetics.

    Pre-Menstrual Syndrome
    One thousand milligrams of Diosmin was studied in 1,473 women with PMS with encouraging results. PMS disappeared completely in 37% of patients while its duration decreased on average by 2.6 days. Symptoms of congestion gradually lessened in terms of both frequency and severity by about 60%, and the same applied to weight issues, with 29% less weight gain in the Diosmin group. Overall, the patients found the results to be very positive.Diosmin may also be useful in the treatment of breast pain or tendernessand abnormal uterine bleeding.

    Other Benefits
    Diosmin may help accelerate wound healing.Animal studies suggest that Diosmin may have anti-cancer effects,but these preliminary resultsneed to be replicated beyond human cell lines.Animal research also suggests that Diosmin may have benefit in Alzheimers disease.Diosmin also appears to improve lymphatic drainageand possess anti-viral activity.

    Diosmin has been found to be very safe in the 40 clinical trials that have been conducted in humans. It has even been found safe for use during pregnancy.

    The typical starting dose is 2-4 capsules per day, with a maintenance dose of 2 capsules per day. It may be taken with or away from meals at any time of day.

    1. Lyseng-Williamson KA, Perry CM. Micronised purified flavonoid fraction: a review of its use in chronic venous insufficiency, venous ulcers and hemorrhoids. Drugs. 2003;63(1):71-100.
    2. Struckmann JR. Clinical efficacy of micronized purified flavonoid fraction: an overview. Journal of vascular research. 1999;36 Suppl 1:37-41.
    3. Kirienko AI, Bogachev V, Zolotukhin IA, Golovanova OV. [Semisynthetic Diosmin (Phlebodia 600) for therapy of lower limb chronic venous insufficiency]. Angiologiia i sosudistaia khirurgiia = Angiology and vascular surgery. 2006;12(2):73-5.
    4. Laurent R, Gilly R, Frileux C. Clinical evaluation of a venotropic drug in man. Example of Daflon 500 mg. Int Angiol. 1988 Apr-Jun;7(2 Suppl):39-43.
    5. Ramelet AA. Clinical benefits of Daflon 500 mg in the most severe stages of chronic venous insufficiency. Angiology. 2001 Aug;52 Suppl 1:S49-56.
    6. Katsenis K. Micronized purified flavonoid fraction (MPFF): a review of its pharmacological effects, therapeutic efficacy and benefits in the management of chronic venous insufficiency. Current vascular pharmacology. 2005 Jan;3(1):1-9.
    7. Savel'ev VS, Pokrovskii AV, Sapelkin SV, Bogachev V, Bogdanets LI, Zolotukhin IA. Micronized diosmin (Detralex) for vein-related trophic ulcers: European experience. Angiologiia i sosudistaia khirurgiia = Angiology and vascular surgery. 2006;12(3):53-60.
    8. Ramelet AA. Daflon 500 mg: symptoms and edema clinical update. Angiology. 2005 Sep- Oct;56 Suppl 1:S25-32.
    9. Pokrovsky AV, Saveljev VS, Kirienko AI, Bogachev VY, Zolotukhin IA, Sapelkin SV, et al. Surgical correction of varicose vein disease under micronized diosmin protection (results of the Russian multicenter controlled trial DEFANS). Angiologiia i sosudistaia khirurgiia = Angiology and vascular surgery. 2007;13(2):47-55.
    10. M, Burak F, Taskin O. Effects of micronized purified flavonoid fraction (Daflon) on pelvic pain in women with laparoscopically diagnosed pelvic congestion syndrome: a randomized crossover trial. Clinical and experimental obstetrics & gynecology. 2007;34(2):96-8.
    11. M. Double-blind, placebo-controlled evaluation of clinical activity and safety of Daflon 500 mg in the treatment of acute hemorrhoids. Angiology. 1994 Jun;45(6 Pt 2):566-73.
    12. AW. Daflon for haemorrhoids: a prospective, multi-centre observational study. Surgeon. 2004 Dec;2(6):335-8, 61.
    13. ZM, Cao JD. The impact of micronized purified flavonoid fraction on the treatment of acute haemorrhoidal episodes. Current medical research and opinion. 2006 Jun;22(6):1141-7.
    14. K, Takkar D, Aggarwal N.Micronized flavonoid therapy in internal hemorrhoids of pregnancy. International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics. 1997 May;57(2):145-51.
    15. C, Bucherer C, Lelievre JC. Hemorheological improvement after Daflon 500 mg treatment in diabetes. Int Angiol. 1988 Apr-Jun;7(2 Suppl):21-4.
    16. y Keenoy B, Vertommen J, De Leeuw I. The effect of flavonoid treatment on the glycation and antioxidant status in Type 1 diabetic patients. Diabetes, nutrition & metabolism. 1999 Aug;12(4):256-63.
    17. P, Behar A. Clinical implications of impaired microcirculation. Int Angiol. 1995 Sep;14(3 Suppl 1):26-31.
    18. PE, Behar A, de Champvallins MM, Attalah M, Boulakia FC, Attali JR. Effects of a purified micronized flavonoid fraction on capillary filtration in diabetic patients. DiabetMed. 1996 Oct;13(10):882-8.
    19. D,Magneron AC. [Premenstrual syndrome in France: epidemiology and therapeutic effectiveness of 1000 mg of micronized purified flavonoid fraction in 1473 gynecological patients]. Contraception, fertilite, sexualite (1992). 1997 Jan;25(1):85-90.
    20. P, Zucconi G, Ottanelli S, Casparis D. [Treatment of mastodynia with synthetic diosmin]. Annali di ostetricia, ginecologia, medicina perinatale. 1985 Sep-Oct;106(5):258-66.
    21. GG, Gajaraj AJ,Mathias J, Marya D. Treatment of abnormal uterine bleeding with micronized flavonoids. International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics. 2005 May;89(2):156-7.
    22. A, Ara C, Ozen S, Kali K, Senol M, Ertas E. Efficacy ofMicronized Flavonoid Fraction in Healing of Clean and InfectedWounds. Int J Angiol. 2001 Jan;10(1):41-4.
    23. Conesa C, Vicente Ortega V, Yanez Gascon MJ, Alcaraz Banos M, Canteras Jordana M, Benavente-Garcia O, et al. Treatment of metastatic melanoma B16F10 by the flavonoids tangeretin, rutin, and diosmin. Journal of agricultural and food chemistry. 2005 Aug 24;53(17):6791-7.
    24. C, Vicente V, Yanez J, Alcaraz M, Castells MT, Canteras M, et al. The effect of the flavonoid diosmin, grape seed extract and red wine on the pulmonary metastatic B16F10 melanoma. Histology and histopathology. 2005 Oct;20(4):1121-9.
    25. S,Wenzel U, Daniel H. Comparative analysis of the effects of flavonoids on proliferation, cytotoxicity, and apoptosis in human colon cancer cell lines. European journal of nutrition. 1999 Jun;38(3):133-42.
    26. K, Shytle RD, Bai Y, Tian J, Hou H,Mori T, et al. Flavonoid-mediated presenilin-1 phosphorylation reduces Alzheimer's disease beta-amyloid production. Journal of cellular and molecular medicine. 2008 Apr 9.
    27. C. A lymphatic function of Daflon 500 mg. Int Angiol. 1995 Sep;14(3 Suppl 1):36-8.
    28. EA, Han MJ, Lee M, Kim DH. In vitro inhibitory effect of some flavonoids on rotavirus infectivity. Biological & pharmaceutical bulletin. 2000 Sep;23(9):1122-4.
    29. OC. Safety and security of Daflon 500 mg in venous insufficiency and in hemorrhoidal disease. Angiology. 1994 Jun;45(6 Pt 2):579-84.
    Manufacturer: Crayhon Research
    SKU: 40050

    Customer Reviews
    Average Rating on 1 Reviews
    (05 stars in 1 rating(s))
    5 star rating Cold feet 12/1/2010 CircuPower by Crayhon Research5
    Reviewed by Terry from Blaine, WA.
    My feet are always cold. Since using CircuPower at only one capsule a day, I've noticed my feet don't feel like their freezing all the time, and I'm feeling less chilled this winter.

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