DHEA output and circulating levels decline steadily with age so that at 70 years
of age, levels are only 20% of those found in young adults (Gaby, 1999). DHEA is
therefore appropriate for those individuals with low circulatory levels and also
for daily supplementation in individuals over 50 years of age, 10mg per day for
females over 50 years of age and 20mg per day for males over 50 years of age.
The functions of DHEA are not totally elucidated but there is a wealth of animal
data which indicates that DHEA is involved in stimulation of the immune system and
is chemo-preventative. This, together with the known decrease of DHEA with age,
has prompted many to associate increased levels of DHEA with greater longevity.
There is significant substance to this claim as evidenced by the synergistic effects
in promoting longevity by combining adrenal competence and calorific restriction
(Pashko & Schwartz, 1992).