DopaBoost™ is designed to support the body’s natural production of dopamine, one of the primary catecholamines. Dopamine is essential for the normal functioning of the central nervous system and is associated with attention, learning, movement, balance, and mood regulation. The primary ingredient in DopaBoost™ is Macuna pruriens, a botanical which naturally contains L-DOPA, the metabolic precursor to dopamine which can cross the blood-brain barrier. Additional ingredients include EGCg (epigallocatechin-3-gallate), acetyl L-tyrosine, quercetin and vitamin B6, all selected for their synergistic roles in the production and regulation of dopamine.
Macuna pruriens - a botanical which naturally contains L-DOPA, the metabolic precursor to dopamine, which can cross the blood-brain barrier. The Macuna material in DopaBoost™ is standardized to contain an extremely potent 60% L-DOPA.
EGCG (from green tea extract) – an antioxidant with brain-protective properties. The polyphenols in green tea offer neuroprotective properties and help to increase the availability of dopamine. EGCG has been shown to have a positive effect on the electrical activity of dopaminergic neurons in the substantia nigra -the area of the brain where dopamine is made.
Quercetin – a flavonoid present in many fruits and vegetables; naturally inhibits COMT (catechol-o-methyl transferase) and MAO activities, the key enzymes involved in the metabolism of dopamine. Quercetin works synergistically with Macuna pruriens and EGCG as it helps to preserve dopamine levels.
N-Acetyl-L-Tyrosine - the acetylated derivative of L-tyrosine, the amino acid from which dopamine is synthesized. Acetylation helps to increase the stability and solubility of tyrosine, making it more efficient and bioavailable, and therefore, the superior choice for raising the body’s levels of tyrosine.
Pyridoxal-5-Phosphate - vitamin B6 in its metabolically active form; needed for the decarboxylation of L-DOPA to dopamine. P5P is a coenzyme for dopa decarboxylase, the enzyme responsible for the conversion of L-DOPA to dopamine.
Serving Size: 2 capsules Servings Per Container: 30
Recommended Dosage: As a dietary supplement, take one capsule two times daily, or as directed by your health care practitioner.
This product does not contain: wheat, yeast, soy, gluten, eggs, ndairy, corn, artificial colors, flavors, sugars, or preservatives.
Who Should Not Take Those who test high in the metabolites HVA and VMA should not take DopaBoost, but instead would benefit from NeuroCalm, a blend of nutrients designed to support calming brain activity.
DopaBoost should not be used with: MAOIs (Nonspecific monoamine-oxidase inhibitors), powerful antidepressant drugs Antipsychotic drugs, such as phenothiazines, butyrophenones and reserpine Antihypertensive drugs such as guanethidine and methyldopa (may cause increased hypotension) Use DopaBoost cautiously with dopaminergic drugs such as amantadine, benserazide, carbidopa, atropine, and amphetamine, only under the guidance of a trained health care professional.
STORE IN A COOL, DRY PLACE. KEEP OUT OF REACH OF CHILDREN.
*All raw materials have been reviewed and validated by DFH QC to be non-GMO (based on supplier documentation)
The adrenal glands produce catecholamines (both hormones and neurotransmitters) in situations of stress such as psychological stress or low blood sugar levels. Dopamine is one of the primary catecholamines. It is essential for the normal functioning of the central nervous system and is associated with attention, learning, movement, balance, and mood regulation. More specifically, dopamine is a signaling substance in brain circuits that can impact mood. It is involved in transmitting signals of reward and motivation and in helping muscles move smoothly. It is synthesized in the brain from the amino acid tyrosine, which is hydroxylated to L-DOPA (3,4 dihydroxy-L-phenylalanine), and then decarboxylated to dopamine. L-DOPA, dopamine's immediate precursor, crosses the blood brain barrier while dopamine does not. Regulating dopamine is vital to our physical and mental health.
DopaBoost was designed to support the body's natural production of dopamine.
Neural Support + Neuroprotection Macuna pruriens is a botanical which naturally contains L-DOPA, the metabolic precursor to dopamine, which can cross the blood-brain barrier. The Macuna material in DopaBoost is standardized to contain an extremely potent 60% L-DOPA.
N-Acetyl-L-Tyrosine is the acetylated derivative of l-tyrosine (the amino acid from which dopamine is synthesized). Acetylation helps to increase the stability and solubility of tyrosine, making it more efficient and bioavailable, and therefore, the superior choice for raising the bodys levels of tyrosine. Pyridoxyal-5-phosphate (P5P), which is vitamin B6 in its metabolically active form, is needed for the decarboxylation of L-Dopa to dopamine, as it is a coenzyme for dopa decarboxylase.
EGCG (epigallocatechin-3-gallate) the main antioxidant and iron chelator polyphenol in green tea works in multiple ways to enhance the efficacy of DopaBoost. EGCG has a positive effect on the electrical activity of dopaminergic neurons (in the substantia nigra). It increases the neuronal activity via inhibition of calcium-dependent potassium currents. Increasing neuronal activity increases the release of dopamine.
Oxidative stress from iron ions Iron in an unstable form increases reactive oxygen species (ROS) and hydrogen peroxide (H2O2). This triggers a cascade of events leading to apoptotic cell death. EGCG, along with the plant flavonoid quercetin, have been demonstrated in research to neutralize radical scavengers. EGCG elevates the activity of two major oxygen-radical metabolizing enzymes, superoxide dismutase and catalase. Quercetin is also a strong protector of nerve cells against free radical damage. Even better, EGCG and quercetin chelate unbound iron (Fe+) and copper ions (Cu+) out of the body.
COMT inhibition by green tea and quercetin Research demonstrates that EGCG and quercetin act as catechol-O-methyltransferase (COMT) inhibitors. The COMT enzyme breaks down dopamine by converting it into methyldopa which does not allow it to convert into dopamine. Therefore, since EGCG and quercetin are COMT inhibitors, they help L-DOPA stay in the system longer for a sustained release of dopamine in the brain. EGCG and quercetin both work synergistically with Macuna pruriens (which provides L-DOPA).
Using Comprehensive Metabolic Testing for Determining Dopamine Levels Testing for low levels of dopamine is a very important and beneficial tool in helping to determine who may benefit from DopaBoost. This can be done by looking at the urine metabolite homovanillate (HVA) found on Designs for Health Metabolic Testing.HVA is found in the urine as a metabolite of dopamine. Low levels of this metabolite may indicate an increased need for dopamine. Elevations of vanilmandelate (VMA) are often found elevated in the urine when HVA is elevated, indicating elevations in the other catecholamines (epinepherine and norepinapherine). Elevated VMA indicates intervention with CatecholaCalm, while low levels of VMA may indicate an increased need for these two catecholamines and therefore intervention with Adrenotone Plus.
Who Should Not Take DopaBoost Those who test high in the metabolites HVA and VMA should not take DopaBoost, but instead would benefit from NeuroCalm, a blend of nutrients designed to support calming brain activity.