Vitex agnus castus has been shown in clinical trials to substantially reduce
the symptoms associated with pre-menstrual syndrome (Lauriter et al, 1997). The
effect is probably due to the flavonoids of Vitex stimulating the
hypothalamus-pituitary axis (HPA) to produce lower levels of
follicle-stimulating tissue (FSH) and normalizing levels of luteinizing hormone
(LH) (Bohsert, 1997).
Black cohosh has been found in clinical trials to reduce hot flushes and
decrease mood fluctuation in peri-menopausal women. This effect was related to a
reduction in luteinizing hormone (LH). (Duker et al., 1991).
Feverfew is a well known botanical pain reliever, especially of headaches and
migraines which are often associated with menstrual difficulties.
Kava kava and St John’s wort are probably the two most effective and
best-known botanical relaxants and mood modulators. Kava enhances relaxation and
St John’s wort alleviates feelings of depression.
Siberian ginseng is included in the formula as a general tonic and
invigorating agent. It combines well with the other botanicals to produce a
heightened state of relaxation and positive mood.
Gamma linolenic acid (GLA) was found in a double blind, placebo-controlled
trial to significantly reduce the symptoms of pre-menstrual syndrome (Larsen et
al. 1989)
Vitamin B6 has proven efficacy in the relief of pre-menstrual syndrome.