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Home > Health Concerns > Digestive GI Health

Florastor: Saccharomyces boulardii by Biocodex

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Florastor: Saccharomyces boulardii by Biocodex
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Florastor

Shown in over 50 years of extensive international use to be safe and effective

In every person there are billions of microorganisms that keep your gut (intestines) working properly. Some medicines, certain diseases, travel and stress can cause an upset of the balance of microorganisms in your body. Florastor helps restore the balance of microorganisms in your intestines and is safe to take with other medicines.

What is Florastor?
The active ingredient in Florastor is lyophilized Saccharomyces boulardii, a probiotic derived from a tropical, non-pathogenic yeast found naturally on the skin of tropical fruit (lychee and mangosteens). It was discovered in Indochina in 1923 by the French scientist Henri Boulard.

In 1947, the founders of Biocodex met with the scientist and arranged to purchase the rights to his strain of Saccharomyces boulardii. (This strain of Saccharomyces boulardii is referred to as lyophilized due to its unique manufacturing process. The strain is therefore labeled Saccharomyces boulardii lyo.) The founders also purchased rights to the fermentation process Boulard had developed. Biocodex still holds the patent on this strain and keeps their unique lyophilization process a closely guarded secret.

The lyophilized yeast cells of the species Saccharomyces boulardii lyo are put into capsules and sealed. Each capsule of Florastor has 250 mg of Saccharomyces boulardii lyo in it, which provides 5 billion CFUs per capsule.

The BIOCODEX Inc., commitment to excellence for our customers Biocodex Inc. has strict manufacturing processes that guarantee each capsule of Florastor contains live yeast cells. There are multiple checking and test points by no fewer than 16 doctors to ensure that the cells are both goodand present in the correct amount prior to being packaged and sold.

What is a probiotic?
Probiotics help the good organisms in your body to grow and protect your intestines against bad organisms that can make you unwell. Florastor keeps your intestines (gut) functioning well. Florastor helps maintain the normal balance of microorganisms in the gut.

Effective: Multiple clinical studies have shown that Saccharomyces boulardii lyo is an effective dietary supplement. Florastor is suitable for all (infants 2 months of age to adults). Florastor is okay to take with antibiotics as it is natural yeast that works even when taken with antibiotics. Making sure you have the right number of good microorganisms may help reduce bloating and gas often caused by an imbalance of microorganisms. Florastor has been shown in over 50 years of extensive international use to be safe and effective.

Florastor:

  • Maintains the balance of good microorganisms in the gut.
  • Keeps the gut functioning well.
  • Promotes intestinal health.
  • Protects good microorganisms in the gut.
  • Improves consistency of bowel movements. Unlike loperamide:
  • Florastor keeps your gut functioning well.
  • Florastor can be taken for more than 2 days.
  • Florastor is natural and does not harmyour intestines.

Suggested Use: 1 capsule in the morning, 1 capsule in the evening

Active Ingredients:

  • Saccharomyces boulardii lyo 250 mg provides 5 billion CFUs per capsules

Inactive Ingredients: Magnesium stearate, Lactose, Hydroxy-propyl-methyl-cellulose, titanium dioxide.

Recommended Dosage:
Swallow capsule whole or mix contents of capsule with water, apple juice or other noncarbonated drinks. Capsule contents can also be added to apple sauce and other soft foods.

Food Florastor can be taken with or without food, with no change in its efficacy.
Drugs Florastor is not harmed by antibiotics because Florastor is a yeast (i.e. non-bacterial)2. Biocodex, Inc. does not recommend taking Florastor in conjunction with antifungals.

Florastor does not have other known drug interactions.

Florastor DOES NOT include any of the following allergens:

  • corn
  • meat
  • egg protein
  • milk protein
  • fish
  • nuts
  • gluten
  • shellfish
  • latex
Note: Florastor may contain traces of soy.

Do not refrigerate. Florastor is produced via a manufacturing method, lyophilization, similar to freeze drying. The lyophilization of Saccharomyces boulardii lyo allows storage at room temperature (25C or 77F), away from excessive moisture, to guarantee an optimal level of living cells for a three-year shelf-life.

Contents of Florastor capsules, when opened, have a creamy color. FlorastorKids packets are pink granules. Both have a yeast-like (i.e. sourdough bread) smell.

Read customer questions and answers about Probiotics on our blog.
Yeast Probiotic Versus Bacterial Probiotic
Florastor provides benefits of a friendly yeast-based probiotic2. Florastor differs from bacterial probiotics for the following reasons:

Yeast cells are bigger than bacterial cells, so yeast can provide increased gut coverage and further protect the intestinal tract.
  • Yeast can withstand the harsh environment of the stomach, while many bacteria are destroyed by acids in the
  • stomach before they even reach the intestines2.
  • The body naturally eliminates the yeast in Florastor within 5 to 7 days after stopping use2.
  • Yeast probiotics, unlike bacterial probiotics, are not compromised by antibiotic use2.
Side Effects
Since 1984 when worldwide tracking began, more than 13 billion doses of Saccharomyces boulardii lyo from Biocodex have been adsministered. With only rare instances of side effects, (less than 1%) patients reported constipation or thirst.

What does Saccharomyces do in the body?
Saccharomyces is a single celled yeast fungus. It is an organism that belongs to the Brewer's Yeast family and is not of the group to which Candida belongs. Though not a permanent resident of the intestine, taken orally it quickly becomes established and "blooms" soon after supplementation has begun. As it blooms, it produces lactic acid and some B vitamins, and has an overall probiotic effect. S. Boulardii is eliminated shortly after supplementation is discontinued. S. Boulardii has been shown to increase secretory IgA and protect gastrointestinal tract against outgrowth of pathogens during use of antibiotics.

What are Probiotics?
Beneficial bacteria, such as Lactobacillus acidophilus and Bifidobacterium bifidum, are called probiotics. Probiotic bacteria favorably alter the intestinal microflora balance, inhibit the growth of harmful bacteria, promote good digestion, boost immune function, and increase resistance to infection. [1 2] People with flourishing intestinal colonies of beneficial bacteria are better equipped to fight the growth of disease-causing bacteria. [3 4] Lactobacilli and bifidobacteria maintain a healthy balance of intestinal flora by producing organic compoundssuch as lactic acid, hydrogen peroxide, and acetic acidthat increase the acidity of the intestine and inhibit the reproduction of many harmful bacteria. [5 6] Probiotic bacteria also produce substances called bacteriocins, which act as natural antibiotics to kill undesirable microorganisms. [7]

What are some food sources of Probiotics?
Beneficial bacteria present in fermented dairy foodsnamely live culture yogurthave been used as a folk remedy for hundreds, if not thousands of years. Yogurt is the traditional source of beneficial bacteria. However, different brands of yogurt can vary greatly in their bacteria strain and potency. Some (particularly frozen) yogurts do not contain any live bacteria. Supplements in powder, liquid extract, capsule, or tablet form containing beneficial bacteria are other sources of probiotics.

Immune Support
In a double-blind trial, it was found that BID supplementation with Bifidobacterium lactis significantly enhanced various aspects of immune function in a group of healthy elderly people.8 Benefits were apparent after only six weeks of supplementation.

Yeast Infections
Regular ingestion of probiotic bacteria may help prevent vaginal yeast infection. [10 11] A review of the research concluded that both topical and oral use of acidophilus can prevent yeast infection caused by Candida overgrowth. [12] Florastor, a non-pathogenic yeast, will not exacerbate or cause a vaginal yeast infection of Candida origin.

Diarrhea
Saccharomyces boulardii, has prevented diarrhea in several human trials. [16] Double-blind research studying critically ill patients found this strain of yeast to prevent diarrhea when 500 mg is taken QID. [17]

Diarrhea flushes intestinal microorganisms out of the gastrointestinal tract, leaving the body vulnerable to opportunistic infections. Replenishing the beneficial bacteria with probiotic supplements can help prevent new infections. The incidence of travelers diarrhea, caused by pathogenic bacteria in drinking water or undercooked foods, can be reduced by the preventive use of probiotics. [13]

Removal of Toxins
Most people know L. acidophilus, the most popular species in this group of probiotic bacteria. However, research shows that other Lactobacillus species may be beneficial as well. For example, L. rhamnosus and L. plantarum appear to be protective intestinal bacteria. They are involved in the production of several gut nutrients, such as short-chain fatty acids, and the amino acids, arginine, cysteine and glutamine. [14] These beneficial bacteria may also help remove toxins from the gut and exert a beneficial effect on cholesterol levels. [15]

Antibiotics
Probiotics are important in re-colonizing the intestine during and after antibiotic use. Probiotic supplements replenish the beneficial bacteria, preventing up to 50% of discomfort and ailments occurring from antibiotic use. [18]

Aids in Digestion
Probiotics also promote healthy digestion. Enzymes secreted by probiotic bacteria aid digestion. Acidophilus is a source of lactase, the enzyme needed to digest milk sugar, which is lacking in those who are lactose-intolerant. [19]

Clinical support: Florastor has been extensively researched, prescribed and recommended by health care professionals, resulting in billions of doses being taken over the past 50 years. There are many published studies supporting the use of Florastor.

All the clinical studies on Saccharomyces boulardii have been conducted using the SB lyo strain found in Florastor. Please see this Data Sheet to read more about this product and what the studies have demonstrated.

References:
1. Smirnov VV, Reznik SR, Viunitskaia VA, et al. The current concepts of the mechanisms of the therapeutic-prophylactic action of probiotics from bacteria in the genus bacillus. Mikrobiolohichnyi Zhurnal 1993;55:92112.
2. Melnikova VM, Gracheva NM, Belikov GP, et al. The chemoprophylaxis and chemotherapy of opportunistic infections. Antibiotiki i Khimioterapiia 1993;38:448.
3. De Simone C, Vesely R, Bianchi SB, et al. The role of probiotics in modulation of the immune system in man and in animals. Int J Immunother 1993;9:238.
4. Veldman A. Probiotics. Tijdschrift voor Diergeneeskunde 1992;117:3458.
5. Kawase K. Effects of nutrients on the intestinal microflora of infants. Jpn J Dairy Food Sci 1982;31:A2413.
6. Rasic JL. The role of dairy foods containing bifido and acidophilus bacteria in nutrition and health. N Eur Dairy J 1983;4:808.
7. Barefoot SF, Klaenhammer TR. Detection and activity of Lactacin B, a Bacteriocin produced by Lactobacillus acidophilus. Appl Environ Microbiol 1983;45:180815.
8. Arunachalam K, Gill HS, Chandra RK. Enhancement of natural immune function by dietary consumption of Bifidobacterium lactis (HN019). Eur J Clin Nutr 2000;54:2639. Perdigon G, Alvarez S, Rachid M, et al. Immune system stimulation by probiotics. J Dairy Sci 1995;78:1597606.
10. Hilton E, Isenberg HD, Alperstein P, et al. Ingestion of yogurt containing Lactobacillus acidophilus as prophylaxis for candidal vaginitis. Ann Intern Med 1992;116:3537.
11. Reid G, Millsap K, Bruce AW. Implantation of Lactobacillus casei var rhamnosus into vagina. Lancet 1994;344:1229.
12. Elmer GW, Surawicz CM, McFarland LV. Biotherapeutic agents.JAMA 1996;275:8706.
13. Scarpignato C, Rampal P. Prevention and treatment of travelers diarrhea: a clinical pharmacological approach. Chemotherapy 1995;41:4881.
14. Bengmark S. Econutrition and health maintenance: A new concept to prevent inflammation, ulceration and sepsis. Clin Nutr 1996;15:110.
15. Bengmark S. Colonic food: pre- and probiotics. Am J Gastroenterol 2000;95(1 Suppl):S57 [review].
16. Golledge CL, Riley TV. Natural therapy for infectious diseases. Med J Aust 1996;164:945 [review].
17. Bleichner G, Blehaut H, Mentec H, Moyse D. Saccharomyces boulardii prevents diarrhea in critically ill tube-fed patients. A multicenter, randomized, double-blind placebo-controlled trial. Intensive Care Med 1997;23:51723.
18. Loizeau E. Can antibiotic-associated diarrhea be prevented? Ann Gastroenterol Hepatol 1993;29:158.
19. McDonough FE, Hitchins AD, Wong NP, et al. Modification of sweet acidophilus milk to improve utilization by lactose-intolerant persons. Am J Clin Nutr 1987;45:5704.
20. Bassetti S, Frei R, Zimmerli W. Fungemia with Saccharomyces cerevisiae after treatment with Saccharomyces boulardii. Am J Med 1998;105:712.
21. Perapoch J, Planes AM, Querol A, et al. Fungemia with Saccharomyces cerevisiae in two newborns, only one of whom had been treated with Ultra-Levura. Eur J Clin Microbiol Infect Dis 2000;19:46870.


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Average Rating
Customer Reviews
Probiotic 7/13/2009
Reviewed by D.M. Plamondon from Belton, Texas.
I have had recurring C-diff infections and have had chronic diarhia for years. I take Florastor once a day. I also take another probiotic and with this combination my diarhia is under control. If I stop either one the effect is noticable. I talked to my physician about what I was taking and with my history she stated I may have to use this combination permanently.

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