GlucoTone Plus Chromium

Comprehensive nutritional support for blood sugar balance.

• Supports healthy blood sugar regulation
• Reduces tendency to insulin resistance
• Provides necessary nutrients for the synthesis of Glucose Tolerance Factor (GTF)

Consider GlucoTone Plus Chromium when prescribing a product for anyone with
impaired glucose metabolism. Gluco Tone Plus Chromium may assist patients
in maintaining healthy glucose metabolism and reduce dysglycemic conditions. It
is comprehensively designed with nutrients to support endogenous production of
Glucose Tolerance Factor which allows for effective uptake of blood glucose into
target cells.

Serving Size:  1 Capsule
Servings Per Container:  60
Product Contains:

• Thiamin (mononitrate).......28mg
• Niacin.......22mg
• Pyridoxal 5 Phosphate.......30mg
• Biotin.......100mcg
• Pantothenic Acid.......500mg
• Magnesium (glycinate).......100mg
• Zinc (histidinate).......9mg
• Chromium (polynicotinate).......100mcg
• Vanadium (aspartate).......50mcg

Other Ingredients:  Silica, Cellulose

Recommended Use:  As a dietary supplement take 1-3 capsules per day or as directed by a healthcare professional.

Read Customer questions and answers about Other Health Concerns in our FAQ.

Thiamin: Thiamin is a necessary cofactor for the metabolism of glucose to create
cellular energy (ATP). Thiamin deficiency is associated with impaired glucose
metabolism which research suggests may be alleviated by B1 supplementation.
Preliminary research also indicates that Thiamin supplementation may have
preventative action against plaque formation within vessel walls. Increased
plaque is a common complication experienced by patients with chronically
elevated serum glucose and insulin levels.

Niacin(B3): is a participant in redox reactions in the metabolic generation of
energy from protein, fat, and carbohydrate sources. Its role in maintaining
adequate cellular energy metabolism may influence blood sugar regulation.

Pyridoxal 5? Phosphate (B6): is important for protein metabolism. It additionally
serves as a cofactor for transaminase enzymes, which allow body proteins
to be converted into glucose molecules. Studies have also found that B6
supplementation may help prevent neuropathies, secondary to elevated blood
glucose. The form of Vitamin B6 provided is the activated form which diminishes
the need for liver phosphorylation.

Biotin: is a component of carboxylase enzymes found within the Krebs cycle which
generate energy from glucose.

Pantothenate (B5): is necessary for the production of endogenous Coenzyme A.
This compound activates fuel sources from carbohydrates, proteins and fats to
allow for their conversion into usable energy.

Magnesium: may affect insulin signaling and the binding of insulin to receptors
therefore influencing glucose metabolism. Some studies have found a positive
correlation between poor magnesium status and impaired glucose tolerance.
Zinc: is needed for optimum insulin function and overall healthy body tissues. Zinc
deficiency may be related to impaired glucose tolerance.

Chromium: is a component of the endogenous compound Glucose Tolerance
Factor (GTF). GTF increases cellular responsiveness to insulin activity therefore
increasing glucose uptake into target cells. In a double-blind crossover study:
8 female patients were supplemented with 200 mcg chromium chloride daily.
By 3 months, low blood sugar symptoms were alleviated and the glucose nadir,
following a glucose load, was raised at 2-4 hours. In addition, insulin binding
to red blood cells and insulin receptor numbers improved significantly. Results
suggest that impaired chromium nutrition and/or metabolism may be a factor in
the cause of low blood sugar.

Vanadium: has been shown to exhibit insulin-like activity in the body. Studies have
shown that vanadium supplementation may improve serum glucose regulation.

REFERENCES:
1. Avena R, Arora S, Carmody BJ, et al. Thiamin (vitamin B1) protects against glucose- and insulinmediated proliferation of human infragenicular arterial muscle cells. Ann Vasc Surg. 2000; 14:37-43.

2. Bakker SJL, Hoogeveen EK, Nijpels G, et al. The association of dietary fibres with glucose tolerance is partly explained by concomitant intake of thiamin: The Hoorn Study. Diabetologia. 1998; 41:1168-1175.

3. La Selva M, Beltramo E, Pagnozzi F, et al. Thiamine corrects delayed replication and decreases production of lactate and advanced glycation end-products in bovine retinal and human umbilical vein endothelial cells cultured under high glucose condtions. Diabetologia. 1996; 39:1263-1268.

4. Elam MB, Hunninghake DB, Davis KB, et al. Effect of niacin on lipid and lipoprotein levels and glycemic control in patients with diabetes and peripheral arterial disease: The ADMIT Study: A randomized trial. JAMA. 2000: 284:1263-1270.

5. Wang W, Basinger A, Neese RA, et al. Effects of nicotinic acid on fatty acid kinetics, fuel selection, and pathways of glucose production in women. Am J
Physiol Endocrinol Metab. 2000; 279:E50-E59.

6. Paolisso G, Sgamabato S, Pizza G, et al. Improved insulin response and action by chronic magnesium administration in aged NIDDM. Diabetes Care. 1989; 12:265-269.

7. Durlach J, Durlach V, Bac P, et al. Magnesium and therapeutics. Magnes Res. 1994; 7:313-328.

8. Anderson RA et al. Effects of supplemental chromium on patients with symptoms of reactive hypoglycemia. Metabolism. 1987; 36(4):351-55.

9. Anderson RA et al. Chromium supplementation of humans with hypoglycemia. Fed Proc. 1984; 43:471.

10. Anderson RA. Chromium, glucose tolerance and diabetes. J Am Coll Nutr. 1998. 17:548-555.

11. Anderson RA, Cheng N, Bryden NA, et al. Elevated intakes of supplemental chromium improve glucose and insulin variables in individuals with type ll
diabetes. Diabetes. 1997; 46:1786-1791.

12. Werbach MR. Nutritional Influences on Illness: A Sourcebook of Clinical Research, 2nd Ed. Third Line Press, Tarzana, CA. 1993.

13. Marz RB. Medical Nutrition From Marz, A Textbook in Clinical Nutrition, 2nd Ed. Omni Press, Portland, OR. 1999.