HLC Endure

High-potency probiotic complex.

HLC endure is manufactured to allow for ambient temperature (20-25C) storage properties and 2 year shelf-life without compromising product stability and still meet or exceed label claims. While refrigeration will extend the shelf-life of probiotics, HLC endure provides a choice for practitioners who are concerned about product viability but do not have refrigeration facilities.

Clinically proven high potency probiotic
Clinically proven in randomized, double-blind, placebo-controlled human trials at 25 billion CFU.

Ambient-Safe
Manufactured to allow for ambient temperature (20-25C) storage and 2 year shelf-life without compromising product stability and still meet or exceed label claims.

Prebiotic to stimulate healthy probiotic strains
Includes prebiotic (FOS) which stimulates the growth of beneficial bacteria in the digestive system.

Serving Size: 1 capsule
Servings Per Container: 30

Active Ingredients:

• HLC Consortium . 12.5 billion C FU
  Lactobacillus acidophilus (CUL-60)
  Lactobacillus acidophilus (CUL-21)
  Bifidobacterium bifidum (CUL-20)
  Bifidobacterium animalis subsp. lactis (CUL-34)
• Fructooligosaccharides (FOS) . . . . . . . . . . . . . . . . . . . . . . 100 mg

Inactive Ingredients: Microcrystalline cellulose, hypromellose, vegetable magnesium stearate, silica.

Recommended Dosage:
Adults and Children (4 years and older): Therapeutic use: One capsule taken two times daily with meals or as professionally directed.

Maintenance use: One capsule taken daily with a meal or as professionally directed.

Risk information:

• If you are experiencing nausea, fever, vomiting, bloody diarrhoea or severe abdominal pain; or if you have an immune-compromised condition, do not use.
• If symptoms of digestive upset occur, worsen or persist beyond three days, discontinue use and consult your healthcare practitioner.

Guaranteed to contain no added wheat, starch, sodium, artificial coloring or flavoring or antimicrobial preservatives. Ideal for vegetarians.

3/30/2012 Ingredient Notice from Seroyal/Genestra regarding lactose, barley gluten and soy in the fermentation medium:

"We have been working to remove the allergens in the fermentation medium with great success. Lactose has been removed. Any lot number after 25322 has lactose free fermentation medium. We have also successfully removed gluten and soy from a research & development perspective. These allergen free fermentation mediums should be available soon."

These nutrients are digested by the micro-organisms during fermentation and further removed during centrifugation (after fermentation).

3/2/2011-Manufacturer's Notice

"We have tested the probiotics as worst-case scenarios based on total daily consumption and target populations and no gluten, dairy or soy was detected in the final product. Although our analytical assay for soy, gluten & dairy did not detect any proteins, these methods cannot detect total absence"

Seroyal research-driven probiotic therapies:

• Clinically proven in randomized, double-blind, placebo-controlled human trials at 25 billion CFU**
  - Reduces symptoms of Irritable Bowel Syndrom (IBS)3
  - Prevents intestinal microflora disruption post-antibiotics4, 5
  - Reduces the incidence of C. difficile associated diarrhea6
• Proprietary non-pathogenic human-sourced microflora bacterial strains
  - Strong epithelial adherence
  - Naturally high tolerance to stomach acid
• Ambient-Safe
  - Manufacturing allows for ambient temperature (20-25C) storage and 2 year shelf-life without compromising product stability and still meet or exceed label claims.

References:

1. Roberfroid M. Prebiotics: The Concept Revisited. J Nutr 2007 Mar;137(3 Suppl 2):830S-7S.
2. Sabater-Molina M, et al. Dietary fructooligosaccharides and potential benefits on health. J Physiol Biochem. 2009 Sep;65(3):315-28.
3. Williams EA, et al. Clinical trial: a multistrain probiotic preparation significantly reduces symptoms of irritable bowel syndrome in a double-blind placebo-controlled study. 2009; 29(1): 97-103.
4. Plummer SF, et al. Effects of probiotics on the composition of the intestinal microbiota following antibiotic therapy. Int J Antimicrob Agents. 2005; 26(1); 69-74.
5. Madden JA, et al. Effect of probiotics on preventing disruption of the intestinal microflora following antibiotic therapy: a double-blind, placebocontrolled
pilot study. Int Immunopharmacol. 2005; (6): 1091-7.
6. Plummer S, et al. Clostridium difficile pilot study: effects of probiotic supplementation on the incidence of C. difficile diarrhoea. Int Microbiol. 2004;7(1):59-62.