Naturally Supports Normal Blood Pressure, Vascular Tone & Cardiovascular Health.
Hypertension (high blood pressure) is one of the most common disorders in the Western world, with a prevalence of about 15% of people having this condition. Hypertension is epidemiologically linked with a higher risk of cardiovascular-related diseases and premature death. HTN Complex is an encapsulated formula by Designs for Health that provides an array of nutrients and herbs to safely promote the maintenance of normal blood pressure and vascular tone, including: Hawthorne Extract (standardized to 2% vitexin), Pomegranate Extract (standardized to 40% ellagic acid), and Taurine. This formula is designed to prevent sugar induced rises in blood pressure, sodium-sensitive blood pressure changes and even renin abnormalities.
Other nutrients in HTN Complex include: Vitamin B-6, folic acid, N-acetyl-cysteine (NAC), lipoic acid, and Albion true chelated forms of magnesium, vanadium, and zinc. HTN Complex can be combined with additional K+2 Potassium, Arginine, Magnesium Malate Chelate, Whey Cool Protein, and Omega Ultra Marine from Designs for Health, Inc. for maximum results and for individuals with significant existing hypertension.
Hypertension (high blood pressure) is one of the most common disorders in the Western world, with a prevalence of about 15% of people having this condition. Hypertension is epidemiologically linked with a higher risk of cardiovascular-related diseases and premature death. HTN Complex is an encapsulated formula by Designs for Health that provides an array of nutrients and herbs to safely promote the maintenance of normal blood pressure and vascular tone. HTN Complex can be combined with additional K+2 Potassium, Arginine, Magnesium Malate Chelate, Whey Cool Protein, and Omega Ultra Marine from Designs for Health, Inc. for maximum results and for the individual with significant existing hypertension [1-8].
HTN Complex Featured Ingredients: Hawthorne (Crataegus oxyacantha): A standardized Hawthorne (2% vitexin) is included in the HTN Complex. This botanical has multiple modes of action including acting as a mild diuretic, ACE-inhibitor, beta-blocker and calcium-channel blocker. It facilitates the relaxation of the vascular smooth muscle, reducing vascular tone and blood pressure. Studies on animals and in-vitro models have also suggested cardiovascular actions that include dilation of coronary arteries. The high bioflavanoid content in Hawthorne has been shown to demonstrate antioxidant activity and cardioprotective effects in experimental ischemic animal models. Both positive and negative ionotropic effects have been observed in studies supportive of the use of Hawthorne in normalizing cardiac rhythm and aiding in the treatment of chronic congestive heart failure [9-12].
Pomegranate (Punica granatum): Standardized pomegranate (40% ellagic acid) is a novel and very important active ingredient in this product. Recent studies have shown that consumption of pomegranate juice which is rich in tannins and a multitude of polyphenolic antioxidant compounds is associated with blood pressure reduction, inhibition of LDL oxidation and foam cell formation, all of which may provide attenuation of atherosclerotic lesions. The blood pressure-lowering properties of pomegranate have been attributed to direct angiotensin-converting enzyme (ACE) inhibition, with one human in vivo study showing a 36% reduction in ACE activity and a 5% reduction in systolic blood pressure. A similar reduction of 31% was also observed in an in vitro study. As a reduction in serum ACE activity, even with no decrease in blood pressure, was previously shown to attenuate atherosclerosis, pomegranate juice extracts may offer a wide array of protection against cardiovascular diseases which could be related to its inhibitory effect on oxidative stress and on serum ACE activity [13-16].
Mechanisms summary of HTN Complex active ingredients Diuretics: Vitamin B6, taurine, Hawthorne, and magnesium Beta-Blockers: Hawthorne Central Alpha Agonists: Hawthorne, potassium, zinc, and B6 Vasodilators: Hawthorne, magnesium, potassium, taurine, and flavanoids Ca+-Channel Blockers: Hawthorne, magnesium, lipoic acid N-acetyl-cysteine, and B6 ACE Inhibitors: Hawthorne, pomegranate and taurine Antioxidants: Hawthorne, pomegranate, bioflavanoids, and lipoic acid Sugar-Induced HTN Modulators: Vanadium and taurine
Homocysteine Reducers: Folic acid and B6 (A reduction in homocysteine has been demonstrated to lower blood pressure) [21, 22, 31, 35]
Taurine: This sulphur-containing amino acid has been shown to have antihypertensive effects through its action as a diuretic, ACE-inhibitor and sympatholytic. The mild and natural diuretic action of taurine lowers blood volume, reducing systemic vascular pressure. Reduction in sympathetic peripheral vasoconstriction can facilitate vasodilation, further reducing blood pressure [17-19].
Other nutrients in HTN Complex include: Vitamin B6, folic acid, N-acetylcysteine (NAC), lipoic acid, and Albion true chelated forms of magnesium, vanadium and zinc [3, 4, 7, 16, 20-37].
Reduce sodium and chloride-rich foods (no more than 1.5-2.5 gms/day) (No snack foods, chips, canned soups, pre-packaged foods and fast food)
Do not add salt at the table
Eat fresh produce daily
Consume adequate amounts of omega-3-fatty acids (i.e.: fish and flax oil)
Exercise regularly
Weight control (within 15% of ideal body weight)
Dickinson, H.O., et al., Lifestyle interventions to reduce raised blood pressure: a systematic review of randomized controlled trials. J Hypertens, 2006. 24(2): p. 215-33.
Geleijnse, J.M., D.E. Grobbee, and F.J. Kok, Impact of dietary and lifestyle factors on the prevalence of hypertension in Western populations. J Hum Hypertens, 2005. 19 Suppl 3: p. S1-4.
Ledoux, J., et al., Calcium-activated potassium channels and the regulation of vascular tone. Physiology (Bethesda), 2006. 21: p. 69-78.
Nakahata, K., et al., Vasodilation mediated by inward rectifier K+ channels in cerebral microvessels of hypertensive and normotensive rats. Anesth Analg, 2006. 102(2): p. 571-6.
Racasan, S., et al., Programming blood pressure in adult SHR by shifting perinatal balance of NO and reactive oxygen species toward NO: the inverted Barker phenomenon. Am J Physiol Renal Physiol, 2005. 288(4): p. F626-36.
Racasan, S., et al., Perinatal L-arginine and antioxidant supplements reduce adult blood pressure in spontaneously hypertensive rats. Hypertension, 2004. 44(1): p. 83-8.
Ramesh Prasad, G., et al., The role of dietary cations in the blood pressure of renal transplant recipients. Clin Transplant, 2006. 20(1): p. 37-42.
Vermeirssen, V., et al., In vitro intestinal transport and antihypertensive activity of ACE inhibitory pea and whey digests. Int J Food Sci Nutr, 2005. 56(6): p. 415-30.
Craig, W.J., Health-promoting properties of common herbs. Am J Clin Nutr, 1999. 70(3 Suppl): p. 491S-499S.
Kocyildiz, Z.C., et al., Crataegus tanacetifolia leaf extract prevents L-NAME-induced hypertension in rats: a morphological study. Phytother Res, 2006. 20(1): p. 66-70.
Vibes, J., et al., Inhibition of thromboxane A2 biosynthesis in vitro by the main components of Crataegus oxyacantha (Hawthorn) flower heads. Prostaglandins Leukot Essent Fatty Acids, 1994. 50(4): p. 173-5.
Walker, A.F., et al., Promising hypotensive effect of hawthorn extract: a randomized double-blind pilot study of mild, essential hypertension. Phytother Res, 2002. 16(1): p. 48-54.
Aviram, M. and L. Dornfeld, Pomegranate juice consumption inhibits serum angiotensin converting enzyme activity and reduces systolic blood pressure. Atherosclerosis, 2001. 158(1): p. 195-8.
Aviram, M., et al., Pomegranate juice consumption for 3 years by individuals with carotid artery stenosis reduces common carotid intima-media thickness, blood pressure and LDL oxidation. Clin Nutr, 2004. 23(3): p. 423-33.
de Champlain, J., et al., Oxidative stress in hypertension. Clin Exp Hypertens, 2004. 26(7-8): p. 593-601.
Uzui, H. and J.D. Lee, [Role of magnesium in hypertension therapy]. Clin Calcium, 2005. 15(11): p. 117-22.
Anuradha, C.V. and S.D. Balakrishnan, Taurine attenuates hypertension and improves insulin sensitivity in the fructose-fed rat, an animal model of insulin resistance. Can J Physiol Pharmacol, 1999. 77(10): p. 749-54.
Hagar, H.H., E. El Etter, and M. Arafa, Taurine attenuates hypertension and renal dysfunction induced by cyclosporine A in rats. Clin Exp Pharmacol Physiol, 2006. 33(3): p. 189-96.
Harada, H., et al., Oral taurine supplementation prevents fructose-induced hypertension in rats. Heart Vessels, 2004. 19(3): p. 132-6.
Al-Awwadi, N., et al., Differential effects of sodium tungstate and vanadyl sulfate on vascular responsiveness to vasoactive agents and insulin sensitivity in fructose-fed rats. Can J Physiol Pharmacol, 2004. 82(10): p. 911-8.
Andersson, S.E., M.L. Edvinsson, and L. Edvinsson, Reduction of homocysteine in elderly with heart failure improved vascular function and blood pressure control but did not affect inflammatory activity. Basic Clin Pharmacol Toxicol, 2005. 97(5): p. 306-10.
Fakhrzadeh, H., et al., Plasma homocysteine concentration and blood pressure in healthy Iranian adults: the Tehran Homocysteine Survey (2003-2004). J Hum Hypertens, 2005. 19(11): p. 869-76.
Haddy, F.J., P.M. Vanhoutte, and M. Feletou, Role of potassium in regulating blood flow and blood pressure. Am J Physiol Regul Integr Comp Physiol, 2006. 290(3): p. R546-52.
Lal, K.J. and K. Dakshinamurti, Calcium channels in vitamin B6 deficiency-induced hypertension. J Hypertens, 1993. 11(12): p. 1357-62.
Lal, K.J. and K. Dakshinamurti, Hypotensive action of 5-HT receptor agonists in the vitamin B6-deficient hypertensive rat. Eur J Pharmacol, 1993. 234(2-3): p. 183-9.
Lal, K.J., S.K. Sharma, and K. Dakshinamurti, Regulation of calcium influx into vascular smooth muscle by vitamin B6. Clin Exp Hypertens, 1993. 15(3): p. 489-500.
Mondo, C.K., et al., N-acetylcysteine antagonizes the development but does not reverse ACTH-induced hypertension in the rat. Clin Exp Hypertens, 2006. 28(2): p. 73-84.
Pechanova, O., et al., Effect of chronic N-acetylcysteine treatment on the development of spontaneous hypertension. Clin Sci (Lond), 2006. 110(2): p. 235-42.
Preuss, H.G., et al., Comparative effects of chromium, vanadium and gymnema sylvestre on sugar-induced blood pressure elevations in SHR. J Am Coll Nutr, 1998. 17(2): p. 116-23.
Shi, S.J., et al., Elevated blood pressure in spontaneously hypertensive rats consuming a high sucrose diet is associated with elevated angiotensin II and is reversed by vanadium. J Hypertens, 1997. 15(8): p. 857-62.
Stehouwer, C.D. and C. van Guldener, Does homocysteine cause hypertension? Clin Chem Lab Med, 2003. 41(11): p. 1408-11.
Thirunavukkarasu, V., A.T. Anitha Nandhini, and C.V. Anuradha, Lipoic acid attenuates hypertension and improves insulin sensitivity, kallikrein activity and nitrite levels in high fructose-fed rats. J Comp Physiol [B], 2004. 174(8): p. 587-92.
Tomat, A.L., et al., Moderate zinc deficiency influences arterial blood pressure and vascular nitric oxide pathway in growing rats. Pediatr Res, 2005. 58(4): p. 672-6.
Tubek, S., Zinc content in lymphocytes and the activity of zinc ion efflux from lymphocytes in primary arterial hypertension. Biol Trace Elem Res, 2005. 107(2): p. 89-99.
van Guldener, C., P.W. Nanayakkara, and C.D. Stehouwer, Homocysteine and blood pressure. Curr Hypertens Rep, 2003. 5(1): p. 26-31.
Vasdev, S., et al., Salt-induced hypertension in WKY rats: prevention by alpha-lipoic acid supplementation. Mol Cell Biochem, 2003. 254(1-2): p. 319-26.
Vasdev, S., et al., Dietary lipoic acid supplementation attenuates hypertension in Dahl salt sensitive rats. Mol Cell Biochem, 2005. 275(1-2): p. 135-41.
Mason, P.J., et al., Blood pressure and risk of secondary cardiovascular events in women: the Women's Antioxidant Cardiovascular Study (WACS). Circulation, 2004. 109(13): p. 1623-9.
Preuss, H.G., Diet, genetics and hypertension. J Am Coll Nutr, 1997. 16(4): p. 296-305.
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Customer Reviews
HTN Complex
8/4/2010
Reviewed by Peggy from Spring Hill, Florida.
I am really pleased with this product. It is a mix of several things I need to take daily. . . all in one capsule!
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