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Cystistatin 60 caps by Ortho Molecular
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Indole Plus by Rx Vitamins

200mg 60 tabs
Today's Price:
$34.00

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Indole-3-carbinol (I3C) is one of the major anticancer substances found in cruciferous vegetables such as broccoli and cabbage. Research shows that I3C helps the body break down harmful estrogens into their safer form for excretion. In particular, research has examined the role of I3C in breast and cervical cancer prevention. Indole-3-carbinol and other glucosinolates are antioxidants and potent stimulators of natural detoxifying enzymes in the body4 5.

Benefits of Indoles Include:

  • May inhibit breast and cervical cancer cell growth
  • Helps the body breakdown and excrete harmful estrogens
  • Helps estrogen metabolism
  • Reduces frequency and size of tumors in lab animals
Ingredients per Tablet:
  • Indole 3-Carbinol 200 mg
  • L-Taurine (pharmaceutical grade amino acid) 20 mg
  • L-Glycine (pharmaceutical grade amino acid) 20 mg
  • Oxidase (5000 units/gram) 5 mg
  • Pyridoxal-5-phosphate 5 mg

Suggested Use: Take two tablets in the morning, on an empty stomach

Other Ingredients: Dicalcium phosphate, microcrystalline cellulose, silica and pharmaceutical glaze.

Read Customer questions and answers about Women's Health in our FAQ.

What are some food sources of Indoles?
Indole-3-carbinol is found in highest concentrations in broccoli, but is also found in other cruciferous vegetables, such as cauliflower, cabbage, and kale.

Lowering Risk of Cancer
Indole-3-carbinol and other glucosinolates are believed to be responsible for the lowered risk of cancer in humans that is associated with the consumption of broccoli and other cruciferous vegetables like cauliflower, cabbage, and kale. [6 7 8 9 10 11 12]

It appears to be especially protective against breast [13 14 15 16] and cervical [17 18] cancer because of a number of actions, including an ability to increase the breakdown of estrogen. However, while most animal studies report protective effects, a few indicate that indole-3-carbinol may actually promote cancer formation in certain situations, depending upon the chemical initiator of cancer, method of exposure, and species of animal studied. [19 20]

Until there is further research and more human clinical data to determine if indole-3-carbinol actually inhibits rather than stimulates cancer formation, some researchers have recommended proceeding with caution when using isolated indole-3-carbinol as a dietary supplement. [21] The areas where its use has currently been documented in humans are only preliminary, but the results are promising. Indole-3-carbinol reduced or halted the formation of papillomas (precancerous lesions) in 12 out of 18 patients with recurrent respiratory tract papillomas. [22] In addition, in a small double-blind trial, supplementation with 200 or 400 mg of indole-3-carbinol per day for 12 weeks reversed early-stage cervical cancer in 8 of 17 women. [23] Preliminary studies have also shown indole-3-carbinol has significantly increased the conversion of estrogen from cancer-producing forms to nontoxic breakdown products. [24 25]

Reduced Tumor Growth
Feeding indole-3-carbinol or broccoli extracts rich in indole-3-carbinol has dramatically reduced the frequency, size, and number of tumors in laboratory rats exposed to a carcinogen. It appears to be especially protective against breast [13 14 15 16] and cervical [17 18] cancer because of a number of actions, including an ability to increase the breakdown of estrogen.

References:
  1. Stoewsand GS. Bioactive organosulfur phytochemicals in Brassica oleracea vegetables?a review. Food Chem Toxicol 1995;33:537?43.
  2. Broadbent TA, Broadbent HS. The chemistry and pharmacology of indole-3-carbinol (indole-3-methanol) and 3-(methoxymethyl) indole. [Part I]. Curr Med Chem 1998;5:337?52.
  3. Broadbent TA, Broadbent HS. The chemistry and pharmacology of indole-3-carbinol (indole-3-methanol) and 3-(methoxymethyl) indole. [Part II]. Curr Med Chem 1998;5:469?91.
  4. Broadbent TA, Broadbent HS. The chemistry and pharmacology of indole-3-carbinol (indole-3-methanol) and 3-(methoxymethyl) indole. [Part I]. Curr Med Chem 1998;5:337?52.
  5. Broadbent TA, Broadbent HS. The chemistry and pharmacology of indole-3-carbinol (indole-3-methanol) and 3-(methoxymethyl) indole. [Part II]. Curr Med Chem 1998;5:469?91.
  6. Hecht SS. Chemoprevention of cancer by isothiocyanates, modifiers of carcinogen metabolism. J Nutr 1999;129:768S?74S [review].
  7. Verhoeven DT, Goldbohm RA, van Poppel G, et al. A review of mechanisms underlying anticarcinogenicity by brassica vegetables. Chem Biol Interact 1997;103:79?129 [review].
  8. Verhoeven DT, Goldbohm RA, van Poppel G, et al. Epidemiological studies on brassica vegetables and cancer risk. Cancer Epidemiol Biomarkers Prev 1996;5:733?48 [review].
  9. Talalay P, Zhang Y. Chemoprotection against cancer by isothiocyanates and glucosinolates. Biochem Soc Trans 1996;24:806?10.
  10. Maheo K, Morel F, Langouet S, et al. Inhibition of cytochromes P-450 and induction of glutathione S- transferases by sulforaphane in primary human and rat hepatocytes. Cancer Res 1997;57:3649?52.
  11. Barcelo S, Gardiner JM, Gescher A, Chipman JK. CYP2E1-mediated mechanism of anti-genotoxicity of the broccoli constituent sulforaphane. Carcinogenesis 1996;17:277?82.
  12. Plumb GW, Lambert N, Chambers SJ, et al. Are whole extracts and purified glucosinolates from cruciferous vegetables antioxidants? Free Radic Res 1996;25:75?86.
  13. Bradlow HL, Sepkovic DW, Telang NT, Osborne MP. Multifunctional aspects of the action of indole-3-carbinol as an antitumor agent. Ann N Y Acad Sci 1999;889:204?13.
  14. Bradlow HL, Sepkovic DW, Telang NT, Osborne MP. Indole-3-carbinol. A novel approach to breast cancer prevention. Ann N Y Acad Sci 1995;768:180?200.
  15. Bradlow HL, Sepkovic DW, Telang NT, Osborne MP. Multifunctional aspects of the action of indole-3-carbinol as an antitumor agent. Ann N Y Acad Sci 1999;889:204?13.
  16. Meng Q, Qi M, Chen DZ, et al. Suppression of breast cancer invasion and migration by indole-3-carbinol: associated with up-regulation of BRCA1 and E-cadherin/catenin complexes. J Mol Med 2000;78:155?65.
  17. Yuan F, Chen DZ, Liu K, et al. Anti-estrogenic activities of indole-3-carbinol in cervical cells: implication for prevention of cervical cancer. Anticancer Res 1999;19(3A):1673?80.
  18. Jin L, Qi M, Chen DZ, et al. Indole-3-carbinol prevents cervical cancer in human papilloma virus type 16 (HPV16) transgenic mice. Cancer Res 1999;59:3991?7.
  19. Oganesian A, Hendricks JD, Pereira CB, et al. Potency of dietary indole-3-carbinol as a promoter of aflatoxin B1-initiated hepatocarcinogenesis: results from a 9000 animal tumor study. Carcinogenesis 1999;20:453?8.
  20. Kim DJ, Han BS, Ahn B, et al. Enhancement by indole-3-carbinol of liver and thyroid gland neoplastic development in a rat medium-term multiorgan carcinogenesis model. Carcinogenesis 1997;18:377?81.
  21. Dashwood RH. Indole-3-carbinol: anticarcinogen or tumor promoter in brassica vegetables? Chem Biol Interact 1998;110:1?5. [review]
  22. Rosen CA, Woodson GE, Thompson JW, et al. Preliminary results of the use of indole-3-carbinol for recurrent respiratory papillomatosis. Otolaryngol Head Neck Surg 1998;118:810?5.
  23. Bell MC, Crowley-Nowick P, Bradlow HL, et al. Placebo-controlled trial of indole-3-carbinol in the treatment of CIN. Gynecol Oncol 2000;78:123?9.
  24. Michnovicz JJ. Increased estrogen 2-hydroxylation in obese women using oral indole-3-carbinol. Int J Obes Relat Metab Disord 1998;22:227?9.
  25. Bradlow HL, Michnovicz JJ, Halper M, et al. Long-term responses of women to indole-3-carbinol
  26. or a high fiber diet. Cancer Epidemiol Biomarkers Prev 1994;3:591?5.
Manufacturer: Rx Vitamins
SKU: 2520

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