For the natural promotion of quality sleep Insomnitol is a formulary blend of botanicals, nutrients, neurotransmitters, and neurotransmitter precursors designed to support quality sleep. By encouraging the calming of brain activity, Insomnitol? helps not only with the ability to get to sleep, but also to stay asleep. Now clinicians can get all of the various interventions typi cally used in natural promotion of quality sleep in one prod uct, improving patient convenience and compliance. Insomnitol may:
Serve as a sleep aid and general relaxant without causing sleep hangover.
Provide a natural sedative effect without causing morning drowsiness.
Reduce generalized anxiety symptoms.
Improve pain tolerance in chronic pain syndromes, increasing the ability to sleep through the night.
Key ingredients include:
Blend of safe nervine botanicals known for their relaxant properties and ability to reduce tension and promote sleep, without causing morning grogginess.
PharmaGABA : a new, proprietary form of GABA (body's main calming neurotransmitter), naturally manufactured through a fermentation process and considered more effective than other traditional, chemically produced synthetic forms of GABA.
L-theanine for support of calming neurotransmitter production, clinically proven to reduce stress and improve the quality of sleep
Melatonin - hormone whose main role is in the control of the circadian (day/night) rhythms. Its production should peak at night and is instrumental for maintaining quality sleep patterns. Melatonin production declines significantly with age, often causing sleep difficulties as sociated with aging.
5-HTP - precur sor to serotonin, supports further melatonin production during the night to help with staying asleep.
Pyridoxyl-5-phospate (activated form of vitamin B6) ? helpful in the conversion of 5-HTP to serotonin (5-HT).
Who Should Take Insomnitol ? Insomnitol? is ideal for those experiencing difficulty getting to sleep, or staying asleep through the night.
Serving Size: 2 capsules Servings Per Container: 30
Recommended Dosage: As a dietary supplement, take two capsules 30-60 minutes before bedtime or as directed by your health care practitioner.
To view the tech sheet of the product, click here.
This product does not contain: wheat, yeast, soy, gluten, eggs, dairy, corn, artificial colors, flavors, sugars, or preservatives. STORE IN A COOL, DRY PLACE. KEEP OUT OF REACH OF CHILDREN. Color, size or shape may appear different between lots. Trademark Information: PharmaGABA? is a trademark of Pharma Foods International Co., Ltd.
Read customer questions and answers about Sleep Disorders on our blog.
About Key Ingredients of Insomnitol? Insomnitol? contains valerian root (Valeriana officinalis), passion flower (Passiflora incarnata), and lemon balm (Melissa officinalis), all safe nervine botanicals known for their relaxant properties and ability to reduce tension and promote sleep, without causing morning grogginess.
Valerian root has demonstrated sedative effects due to its ability to induce the release of GABA from brain tissue. It has been suggested that the passion flower and German chamomile (Matricaria recubita) constituent apigenin binds to central benzodiazepine receptors, possibly causing anxiolytic effects (anxiety reducing) without impairing memory, diminishing motor skills, or causing drowsiness upon awakening.
Lemon balm has been suggested to improve calmness via the inhibitory action of GABA, similar to benzodiazepine, but without the overt side-effects of these medications. Direct stimulation of Gamma aminobutyric acid (GABA), the main calming neurotransmitter in the body, is provided with a new form of GABA known as PharmaGABA?, a proprietary material naturally manufactured via a fermentation process and considered more effective than other traditional, chemically produced synthetic forms. In addition, support of calming neurotransmitter production is provided with the inclusion of L-theanine, clinically proven to reduce stress and improve the quality of sleep.
Insomnitol? also includes melatonin, a multifunctional hormone whose main role lies in its involvement in the control of the circadian (day/night) biological rhythms. Melatonin mediates the body's response to variations of natural light availabilityfrom indoor/outdoor exposure or due to seasons (winter/summer). Darkness into the eye tells the brain to make melatonin so the body can prepare for sleep mode. Its production should peak at night and it is instrumental for maintaining quality sleep patterns.
Melatonin production declines significantly with age, often causing sleep difficulties associated with aging. Supplemental melatonin was shown in studies to help with falling asleep when taken about 30 minutes before the desired sleep time. The most common dose found effective for sleep was 3mg.
5-HTP can be used in conjunction with melatonin, as a precursor to serotonin, which can further support endogenous melatonin production during the night to help with staying asleep. When using 5-HTP for enhancing serotonin and melatonin production to promote healthy mood and sleep, the addition of the synergistic nutrient pyridoxyl-5-phospate, an activated form of vitamin B6, is suggested to catalyze the conversion of 5-HTP to serotonin (5-HT).
Caution with GABA Due to the inclusion of GABA, this product is not recommended for pregnant or lactating women, as well as young children, unless under the guidance of a health care practitioner. Conditions for which melatonin is not recommended:
Autoimmune conditions such as lupus or rheumatoid arthritis, because the immune stimulatory effect of melatonin may exacerbate the action of certain types of lymphocytes or B-cells involved in the pathogenic course of these diseases.
Immune-related cancers such as lymphoma and leukemia.
Pregnancy, lactation or during the time where fertility is desired.
As shown in vitro, melatonin has been suggested as possibly playing a beneficial role in osteoarthritis. Possible mechanisms include the enhancement of cartilage matrix synthesis and the inhibition of fibroblast-like synoviocyte proliferation.
Interactions with drug therapy Melatonin and 5-HTP may not be suitable to administer along with SSRI and MAOI medications and corticosteroid therapy. Please discuss this with your health care provider before using Insomnitol? with these medication classes.
References:
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On the spasmolytic activity of valeriana extracts (author?s transl). Wagner H, Jurcic K. Planta Med 1979;37:84-86. [Article in german]2.
Valeriana officinalis Monograph.. Altern Med Rev 2004 Dec;9(4):438-41.3.
Passiflora: a review update. Dhawan K, Dhawan S, Sharma A. J Ethnopharmacol 2004 Sep;94(1):1-23.4.
Passion flower (Passiflora incarnata L.)-a reliable herbal sedative. Wien Krenn L. Med Wochenschr 2002;152(15-16):404-6. [Article in German]5.
Attenuation of laboratory-induced stress in human after acute administration of Melissa officinalis (Lemon Balm). Kennedy DO, Little W, Sc6.
holey AB. Psychosom Med 2004 Jul-Aug;66(4):607-13.
Plants and the central nervous system. Carlini EA. Pharmacol Biochem Behav 2003 Jun;75(3):501-127.
Flavonoids from lemon balm (Melissa officinalis L., Lamiaceae). Patora J, Klimek B. Acta Pol Pharm 2002 Mar-Apr;59(2):139-43.8.
Phytochemical and biological analysis of skullcap (Scutellaria lateriflora L.): a medicinal plant with anxiolytic properties. Awad R, Arnason JT, 9. Trudeau V, et al. Phytomedicine 2003 Nov;10(8):640-9.
L-Theanine reduces psychological and physiological stress responses. Kimura K, Ozeki M, Juneja L, Ohira H (2007). Biol Psychol 74 (1): 10. 39?45.
Sleep-inducing effects of low doses of melatonin ingested in the evening. Zhadanova IV, Wurtman RJ, Lynch HJ, et al. Clin Pharmacol Ther 11. 1995;57:552-8.
The role of melatonin and circadian phase in age-related sleep maintenance insomnia: assessment in a clinical trial of melatonin replacement. 12. Hughes RJ, Sack RL, Lewy AJ. Sleep 1998;21:52-68.
A double-blind trial of melatonin as a treatment for jet lag in international cabin crew. Petrie K, Dawson AG, Thompson L, et al. Biol Psychiatry 13. 1993;33:526-30.
Textbook of Natural Medicine (2nd Ed.). Pizzorno JE, Murray MT. Churchill Livingstone, New York, 1999.14.
Complimentary & Alternative Medicines: Professional?s Handbook. Fetrow CW, Avila JR. Springhouse, Springhouse, PA, 1999.15.
Botanical Influences on Illness: A sourcebook of clinical research. Werbach MR, Murray, MT. Third Line Press, Tarzana, California, 1994.16.
Incorporating Herbal Medicine Into Clinical Practice. Bascom A. F.A. Davis Co., Philadelphia, 2002. 17.
Encyclopedia of Herbal Medicine. Cheallier A. Dorling Kindersley, London, 2000.18.
Pharmacognosy and Pharmacobiotechnology. Robbers JE, Speedie MK, Tyler VE. Williams & Wilkins, Baltimore, 1996.19.
PDR for Nutritional Supplements, 1st Ed. Medical Economics/Thompson Healthcare, 2001.20.
PDR for Herbal Medicines, 1st Ed. Medical Economics/Thompson Healthcare, 1998.21
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