Lithium Synergy

Lithium Synergy? may help support:

• Mood disorders
• Depression
• *Bipolar disorder
• Alzheimer's disease progression
• Nerve damage
• Disruptive behavior disorders in children and adolescents
• Episodic impulsive aggressiveness
• Kleptomania
• Fragile X Syndrome (FXS is a genetic flaw that causes certain forms of autism, learning disabilities, anxiety disorders and mental retardation)
  

Lithium Synergy? combines lithium orotate, known for its ability to help stabilize mood swings related to depression and other mood disorders, with vitamin B12 (methylcobalamin) and trimethylglycine to support healthy methylation pathways.

Serving Size: 1 capsule

Recommended Use: The recommended dose for most applications is 1-4 capsules per day in divided doses with or without food.

Product Contains:

• Vitamin B12 (as Methylcobalamin) 250mcg,
• Lithium (as Lithium Orotate) 5mg,
• Trimethylglycine (TMG) 200mg

Other Ingredients: Microcrystalline cellulose, vegetable stearate

This product does not contain: wheat, yeast, soy, gluten, eggs, dairy, corn, artificial colors, flavors, sugars or preservatives.

How does lithium orotate work?
Mood disorders are often due to inositol depletion. Lithium recycles and synthesizes inositol by inhibiting IMPase enzyme. The phosphoinositol signaling pathway is involved in cell membrane signaling cascades. When salts of lithium are ingested, the lithium ions interact with several neurotransmitters and receptors in the central nervous system resulting in decreased norepinephrine release and increased serotonin synthesis.

Why add vitamin B12 and TMG (trimethylglycine)?
Vitamin B12 in the form of methylcobalamin and trimethylglycine both can donate methyl groups to improve methylation, often a weakness in patients with depression and other disorders.

Observational studies have found as many as 30% of patients hospitalized for depression are deficient in vitamin B12. The reasons for the relationship between vitamin B12 deficiency and depression may involve s-adenosylmethionine (SAMe). Vitamin B12 is required for the synthesis of SAMe, a methyl group donor essential for methylation reactions and subsequently the metabolism of neurotransmitters. SAMe deficiency has been related to depression. This hypothesis is supported by several studies that have shown supplementation with SAMe improves depressive symptoms

Caution: Taking patients off of prescription lithium may result in a rebound effect. Lithium levels should be monitored by a qualified health care professional.

This product should not be used to replace any anti-depressant medication, including prescription forms of lithium, unless under the direction of a qualified health care practitioner. Lithium should not be used by individuals with significant renal or cardiovascular diseases, severe debilitation or dehydration, or sodium depletion, or by individuals who are taking diuretics or ACE inhibitors. Consult your doctor before use if you are taking anti-hypertensive drugs, anti-inflammatory drugs, analgesic drugs or insulin. Lithium should not be used by pregnant women and breast-feeding mothers. Serum lithium levels should be monitored by a qualified health care provider during use.