Formerly Metabolic Formula Number One™

Metabolic Synergy
This multivitamin and mineral formula was designed by a medical doctor specializing in blood sugar and endocrine health concerns. It includes state-of-the-art, newly researched, anti-glycating agents such as carnosine, benfothiamine and pyridoxamine. The mineral forms have been improved.

Metabolic Synergy™ may help:

Support conversion of carbohydrates to energy

Lower fasting and average glucose levels (hemoglobin A1C)

Lower fasting and average insulin and leptin levels with improved tissue sensitivity

Reduce risk of dysglycemia (blood sugar highs and lows)

Support pancreatic sensitivity & ability to produce adequate amounts of insulin

Help prevent problems associated with out-of- control sugar levels (glycation) such as:

• neuropathy
• retinopathy
• kidney damage
• blood vessel damage
• pancreatic damage

Prevent nutrient deficiencies induced by excessively high glucose/insulin levels

Lower cardiovascular complications associated with diabetes and insulin resistance

Protect from metabolic damage induced by excessive fructose consumption

Lower homocysteine

See "More Info" tab to read more...

Serving Size:  6 capsules
Product Contains:

• Vitamin A (from Palmitate, fish, and mixed
  carotenoids from palm tree fruit)........3,000 IU
• Vitamin C (as Ascorbic Acid)........500 mg
• Vitamin D3 (as Cholecalciferol)........400 IU
• Vitamin E........50 IU
  • d-gamma tocopherol........100 mg
  • d-delta tocopherol........42 mg
  • d-alpha tocopherol........22 mg
  • d-beta tocopherol........3 mg
• Vitamin B1 (as Thiamine HCI 25 mg and
  Benfothiamine 50 mg)........75 mg
• Vitamin B2 (as Riboflavin)........25 mg
• Vitamin B3 (as Niacinamide)........50 mg
• Vitamin B6 (as Pyridoxil HCI, Pyridoxal-5-Phosphate)........50 mg
• Folates (NatureFolate™ blend)........400 mcg
• Vitamin B12 (as Methylcobalamin)........1,000 mcg
• Biotin (as d-biotin)........4 mg
• Pantothenic Acid ( as d-Calcium Pantothenate)........50 mg
• Iodine (as Potassium Iodide)........75 mcg
• Magnesium (TRAACS®
  Magnesium LYSYL Glycinate Chelate)........100 mg
• Zinc (TRAACS® Zinc Glycinate Chelate)........30 mg
• Selenium (as Selenium Glycinate Complex)........200 mcg
• Manganese (TRAACS® Manganese Glycinate Chelate)........3 mg
• Chromium (TRAACS®
  Chromium Nicotinate Glycinate Chelate)........500 mcg
• Molybdenum (TRAACS®
  Molybdenum Glycinate Chelate)........100 mcg
• Potassium (as Potassium Glycinate Complex)........200 mg
• Alpha Lipoic Acid........600 mg
• Taurine........600 mg
• Inositol........500 mg
• Green Tea (Camellia Sinensis) (leaf)
  ........200 mg [standardized to contain 95% polyphenols]
• Carnosine........200 mg
• Benfothiamine........50 mg
• Vanadium (TRAACS®
  Vanadium Nicotinate Glycinate Chelate)........200 mcg.

Other Ingredients:  Microcrystalline cellulose, rice flour, magnesium stearate.

Recommended Use:  As a dietary supplement, take six capsules per day with meals or as directed by your health care practitioner.

This product does not contain:  wheat, yeast, soy, gluten, eggs, dairy, corn, artificial colors, flavors, sugars, or preservatives.

Read Customer questions and answers about Weight Loss in our FAQ.

Metabolic Formula Number One, designed for blood sugar problems, has been renamed and redesigned. The improved version is now called Metabolic Synergy™, an ideal formula for individuals with metabolic syndrome. This multivitamin was originally designed by a diabetes specialist, Dr. Ron Rosedale. It was updated with the help of Dr. Bob Steinberg. It now includes two more state of the art, newly researched anti-glycating agents carnosine and benfothiamine (a form of vitamin B1) for preventing diabetic complications.

The mineral forms have also been improved. The magnesium, chromium, zinc, manganese and vanadium are now true chelates from Albion, the leader in the manufacture of mineral chelates with superior absorption. A few core nutrients have been added to make Metabolic Synergy™ a complete multivitamin mineral.

The following has been added to this amazing formula:

600 mg lipoic acid + 4 mg biotin—prevents the typical reduction in carboxylase enzymes seen in research when lipoic acid is given alone. These two nutrients together aid healthy insulin secretion and glucose metabolism.

600 mg taurine, 100mg EGCg from green tea and 400 IU vitamin D—all of which help insulin to work better

50 mg benfothiamine, 200 mg carnosine and 100 IU of high gamma vitamin E—to protect from neuropathy & kidney damage

3000 IU vitamin A—important for immune system

25 mg vitamin B1 (as thiamine HCl)—needed for energy

100 mcg molybdenum—needed for detoxification

Metabolic Synergy™ provides nutrients needed for the TCA (tricarboxylic acid) cycle. This is also known as the Krebs cycle or citric acid cycle. This cycle allows the body to burn food for energy by converting glucose into ATP. The more glucose burned, the less glucose in the bloodstream.

Nutrients needed for the TCA cycle include magnesium, manganese and lipoic acid. Vanadium and magnesium, due to their insulin mimicking action, help glucose get inside cells where this burning occurs. These two nutrients are also helpful for blood pressure problems.

Benefits of Metabolic Formula One:

Support conversion of carbohydrates to energy

Lower fasting and average glucose levels (hemoglobin A1C)

Lower fasting and average insulin and leptin levels with improved tissue sensitivity

Reduce risk of dysglycemia (blood sugar highs and lows)

Support pancreatic sensitivity & ability to produce adequate amounts of insulin

Help prevent problems associated with out-of- control sugar levels (glycation) such as:

• neuropathy
• retinopathy
• kidney damage
• blood vessel damage
• pancreatic damage

Prevent nutrient deficiencies induced by excessively high glucose/insulin levels

Lower cardiovascular complications associated with diabetes and insulin resistance

Protect from metabolic damage induced by excessive fructose consumption

Lower homocysteine

Metabolic syndrome is a condition many people risk developing by the time they reach middle age. Metabolic syndrome is defined as a cluster of symptoms or disorders including insulin and leptin resistance, hyperlipidemia (elevated cholesterol and triglycerides), high blood pressure and overweight (weight gain in the belly region is a tell-tale sign). The factors that may lead to these conditions are:

Excessive carbohydrate consumption, with especially damaging effects from fructose and galactose

Excessive stored body fat, especially in the abdominal area, due to its active hormonal activity

Nutrient deficiencies (inositol, chromium, vanadium, magnesium, zinc, omega-3 fatty acids, vitamin D, taurine, vitamin C, vitamins B1, B2, B3)

High oxidative stress, which depletes antioxidants

Prolonged demand on the pancreas to produce insulin

Excessive stress (high adrenaline and cortisol)

A sustained program of lifestyle and diet changes combined with proper nutrient supplementation can reverse and correct most of the underlying causes of the metabolic syndrome

Metabolic Synergy™ is protective against many complications associated with out-of-control glucose levels by reducing its ability to glycate various body proteins in the bloodstream, which in turn has damaging effects on the eyes, brain, kidney, etc. This is achieved with the help of lipoic acid, carnosine and benfothiamine, which have been proven to reduce the risk of neuropathy/retinopathy along with support from vitamin B6, B12 and high gamma vitamin E. This formula has multiple antioxidants for controlling the oxidative stress common in a diabetic.

Excessive fructose consumption can lead to excessive glycation of proteins (up to 16 times faster), hypertension, impaired insulin function (via reduced tyrosine phosphorylation). Metabolic Synergy™ reduces the damaging effects of fructose consumption through EGCg, zinc, and taurine.

The benefits of normalizing glucose, insulin, and leptin metabolism include: reduced risk of diabetes-related complications (neuropathy, kidney or vision damage), lower cardiovascular risk (lower blood pressure, triglycerides, increased HDL, better endothelial function), reduced cell proliferation (tumors), less water retention, less fat storage and easier fat release from the adipose cells.

This product works well with Designs for Health PaleoGreens™, EndoTrim™, PaleoFiber™ and CLA

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Biotin: Balancing Blood Sugar
A high intake of biotin can improve blood sugar control in animal models of type II diabetes. By helping keep blood sugar and insulin lower, biotin may support weight loss.1 Biotin may also help patients with diabetic neuropathy.[2]

Niacinamide: Antioxidant Aiding Glucose Control
Niacinamide may improve glucose control in type II diabetics.[5] Some also find that they feel more relaxed when taking niacinamide.

Low levels of inositol occur in patients with diabetes, suggesting inositol may be of benefit here as well.

Diabetes
Zinc is very important because of its ability to balance blood sugar.[3] Zinc helps the pancreas manufacture insulin and may protect the receptor sites on all cell membranes that allow the hormone to enter.[4]

Click here to download Metabolic Synergy PDF file

Store in a cool, dry place. Keep out of reach of children.

1. Hipkiss AR, Brownson . Reaction of carnosine with aged proteins: another protective process? Ann N Y Acad Sci. 2002 Apr;959:285-94.
2. Waltner-Law ME, Wang XL Epigallocatechin gallate, a constituent of green tea, represses hepatic glucose production. J Biol Chem. 2002 Sep 20;277(38):34933-40. Epub 2002 Jul 12.
3. Jacob S, Ruus P, Hermann R, Oral administration of RAC-alpha-lipoic acid modulates insulin sensitivity in patients with type-2 diabetes mellitus: a placebo-controlled trial. Free Radic Biol Med. 1999 Aug;27(3-4):309-14.
4. Boucher BJ . Inadequate vitamin D status: does it contribute to the disorders comprising syndrome 'X'? Br J Nutr. 1998 Apr;79(4):315-27.
5. Hammes HP, Du X . Benfotiamine blocks three major pathways of hyperglycemic damage and prevents experimental diabetic retinopathy. Nat Med. 2003 Mar;9(3):294-9. Epub 2003 Feb 18.
6. Maassen JA, Mitochondrial diabetes, diabetes and the thiamine-responsive megaloblastic anaemia syndrome and MODY-2. Diseases with common pathophysiology? Panminerva Med. 2002 Dec;44(4):295-300.
7. Ozcelikay AT, Becker DJ. Improvement of glucose and lipid metabolism in diabetic rats treated with molybdate. Am J Physiol. 1996 Feb;270(2 Pt 1):E344-52.