Omegavail Synergy w/Lipase

OmegAvail Synergy (formerly OmegAvail Synergy TG) still provides the same levels of omega-3 fatty acids per serving. The only change we've enhanced this product with the addition of lipase, a digestive aid.

Also, you will note a slight change in the color of the softgel, which is related to the inclusion of lipase, the enzyme crucial to the digestion and absorption of fatty acids.

This unique formula contains a blend of wild deep-sea sourced fish oils containing the omega-3 fats (EPA/DHA) in theTruTG form, the omega-3 fat alpha linolenic acid (ALA) from flax seed oil and the most important omega-6 fat, GLA, from borage oil. EPA helps keep GLA metabolism in an anti-inflammatory mode. In addition, docosahexaenoic acid (DHA) plays as many important roles in human health as EPA, with an added benefit to brain function.

The TruTG Advantage
OmegAvailSynergy still carries our TruTG seal, your assurance that the fish oils are in their natural triglyceride form and are of unmatched TG potency. Fish oils in the TG (triglyceride) form are as they occur in nature. Fish oil blends and concentrates bearing the TruTG seal are 90% to 100% triglyceride (TG) bound omega-3 oils 40%-50% higher than the industry standard for TG fish oil concentrate products!

Why the addition of lipase
We have added lipase as a digestive aid. Lipase is an enzyme needed for breaking down lipids (fats). Lipase is primarily produced in the pancreas but is also produced in the mouth and stomach.

While most healthy individuals produce sufficient amounts of pancreatic lipase, everyone can benefit from its inclusion as it relates to better digestion of fish oils. This is supported by studies that address:

The importance of lipase for the efficient digestion of dietary fats.

• The need for lipase for those with digestive disorders that lead to pancreatic enzyme insufficiency
• Why more lipase may be needed beyond normal production in the pancreas

Serving Size: 2 softgels
Servings Per Container: 90

Amount per Serving:

• Calories 18
• Calories from Fat 18
• Total Fat 2 g
• Cholesterol less than 10 mg
• Omega 3 Fatty Acids
• ALA (Alpha Linolenic Acid) 400 mg
• EPA (Eicosapentaenoic Acid) 270 mg
• DHA (Docosahexaenoic Acid) 180 mg
• Omega 6 Fatty Acids
• GLA (Gamma Linolenic Acid) 160 mg

Inactive Ingredients: Bovine gelatin, glycerin, water, natural lemon flavor, lipase, annatto, and mixed tocopherols.

Recommended Use:
As a dietary supplement, take two softgels daily with meals or as directed by your health care practitioner.

Contains fish. Manufactured from anchovy, sardines, mackerel or tuna oil.

NOTICE: Color, size or shape may appear different between lots.

WARNING: Consult with your health care practitioner before use if you are taking blood thinning medication or are planning to have surgery.

REFRIGERATE AFTER OPENING. KEEP OUT OF REACH OF CHILDREN

OmegAvail Synergy has gone through an extensive purification process and is verified by third party testing to be free of pesticides, PCBs, dioxin and heavy metals, including mercury.

OmegAvail Synergy delivers four beneficial fatty acids in one softgel: EPA and DHA from fish oil, GLA from borage oil, and ALA from flax seed oil. OmegAvail Synergy includes TruTG fish oil which contains a minimum 90% natural TG (triglyceride) bound omega 3 oil.

The TruTG Advantage

Fish oil is considered by many if not the majority of nutritionally focused health care practitioners to be the single most important dietary supplement. In all probability, no other nutritional product has as much and varied research demonstrating its many health benefits.

Designs for Health has consistently embraced the Paleolithic nutritional philosophy upon which it was founded. As such, we are excited to announce our TruTG branded fish oil products which are guaranteed to contain 90 to 100% triglyceride-bound EPA and DHA fats. Both EPA and DHA are found naturally in fish in this triglyceride form.

The Form Nature Intended

Only Designs for Health fish oil products carry the TruTG seal your assurance that our fish oils are delivered in the form found in nature, consistent with Paleolithic nutritional philosophy, and are of unmatched TG potency. Fish oil blends and concentrates bearing the TruTG seal are 90 to 100% triglyceride (TG) bound omega-3 fish oils, which are 40%-50% higher than industry standard for TG fish oil concentrate products!

Converting Ethyl Esters to Triglycerides - Why DFH Chose a Path Less Followed

The vast majority of fish oil concentrate products available on the market today are Ethyl Esters. Not surprisingly, the reason is cost; an additional step is required to convert EEs back into their natural TG state. This added process removes the ethanol backbone and re-esterifies the omega-3 fatty acids to a glycerol backbone. Interestingly, most of the companies that choose to take this extra step and expense convert just 60 - 65% of the oil to TG leaving a mixture of EE, and mono and diglyceride oil in the remainder.

At Designs for Health, we have always placed quality, efficacy and safety above cost. This is precisely why we convert to TG the maximum amount possible, between 90% and 100%. TruTG defines this process, resulting in the highest expense, but also resulting in a finished product with the highest stability, bioavailability, and that closest to what is found in nature.

Superior Absorption and Biovailability

Numerous studies have assessed the absorption and bioavailability of EE fish oils by measuring the amount of EPA and DHA in blood plasma after ingestion of fatty acids as either TGs or EEs. Although a few studies have found the absorption rate to be similar between the two types of oils, overall evidence suggests that TG fish oils are better absorbed in comparison to EEs. One of the causative factors for the poor bioavailability of EE fish oil is a much greater resistance to digestive enzymes. During the digestive process, pancreatic lipase enzymes hydrolyze (cleave) the oils to liberate the fatty acids, and EE fish oil is much more resistant to this enzymatic process than the natural TG form.

A recent study assessed the specificity of 5 lipases towards EPA and DHA in TG and EE forms of fish oil. All of the investigated lipases hydrolyzed EPA and DHA more easily from a TG than from an EE fish oil substrate. It follows that EPA and DHA hydrolysis would be further compromised in individuals suffering from a digestive disorder, such as pancreatic insufficiency. EE fish oils should be avoided in such populations, as they would likely cause malabsorption of EPA and DHA.

A review of the existing literature provides evidence suggesting that omega-3 fatty acids in the natural TG form are more efficiently digested and significantly better incorporated into plasma lipids when compared to the EE form.

More Stable, Less Prone to Oxidation

Omega-3 fish oils in the form of EEs are much less stable than those in the natural TG form, making them more prone to oxidation. The oxidation kinetics of DHA as an EE or as a TG were assessed by measuring the concentration of oxygen found in the head space of a reaction vessel with both TG and EE forms3. The EE form of DHA was more reactive, and quickly oxidized, demonstrating that EE fish oils are far less stable and more readily produce harmful oxidation by-products3. In addition, the stability of DHA containing oil in phospholipid, triacylglycerol and the EE form has been assessed4. After a 10-week oxidation period, the EE DHA oil decayed 33% more rapidly than other forms4. In a separate study, monoglycerides were shown to be more readily oxidized when compared to triglycerides.

This suggests that individuals with health conditions associated with excessive oxidative stress should ideally consume only a 90+% TG form of fish oil.

References
1. Omega-3 fatty acids: the science and the beliefs. Ginsberg A, Stahl Z, Leventhal A. Harefuah. 2009 Feb;148(2):114-20, 138.
2. Lipolysis of menhaden oil triacylglycerols and the correŠsponding fatty acid alkyl esters by pancreatic lipase in vitro: a reexamination. Yang LY, Kuksis A, Myher JJ. J Lipid Res. 1990 Jan;31(1):137- 47.
3. Autoxidation kinetic analysis of docosahexaenoic acid ethyl ester and docosahexaenoic triglyceride with oxygen sensor. Yoshii H, Furuta T, Siga H, Moriyama S, Baba T, Maruyama K, Misawa Y, Hata N, Linko P. Biosci Biotechnol Biochem. 2002 Apr;66(4):749-53.
4. Oxidative stability of docosahexaenoic acid-containing oils in the form of phospholipids, triacylglycerols, and ethyl esters. Song JH, Inoue Y, Miyazawa T. Biosci Biotechnol Biochem. 1997 Dec;61(12):2085-8.
5. Oxidation of monoglyceride, diglyceride, and triglyceride monolayers by aqueous potassium per manganate solution. Singh C. P. ; Shah D. O.
6. [Comparative bioavailability of eicosapentaenoic acid and docasahexaenoic acid from triglycerides, free fatty acids and ethyl esters in volunteers] Beckermann B, Beneke M, Seitz I. Arzneimittelforsc hung. 1990 Jun;40(6):700-4. German.
7. Human absorption of fish oil fatty acids as triacylglycerols, free acids, or ethyl esters. Lawson LD, Hughes BG. Biochem Biophys Res Commun. 1988 Apr 15;152(1):328-35.
8. Enteral absorption in man of eicosapentaenoic acid in different chemical forms. el Boustani S, Colette C, Monnier L, Descomps B, Crastes de Paulet A, Mendy F. Lipids. 1987 Oct;22(10):711-
9. Dietary intake of fish vs. formulations leads to higher plasma concentrations of n-3 fatty acids. Visioli F, Risé P, Barassi MC, Marangoni F, Galli C. Lipids. 2003 Apr;38(4):415-8.
10. Effect of supplementation with docosahexaenoic acid ethyl ester and sn-2 docosahexaenyl monoa cylglyceride on plasma and erythrocyte fatty acids in rats. Valenzuela A, Valenzuela V, Sanhueza J, Nieto S. Ann Nutr Metab. 2005 Jan-Feb;49(1):49-53. Epub 2005 Feb 25.
11. Digestion and lymphatic transport of eicosapentaenoic and docosahexaenoic acids given in the form of triacylglycerol, free acid and ethyl ester in rats. Ikeda I, Sasaki E, Yasunami H, Nomiyama S, Nakayama M, Sugano M, Imaizumi K, Yazawa K. Biochim Biophys Acta. 1995 Dec 7;1259(3):297-304.
12.  S.D.Kristensen, E.B. Schmidt, R. DeCaterina, S. Endres n-3 Fatty Acids: Prevention and Treatment in Vascular Disease; Chapter 20. Bioavailability of n-3 Fatty Acid Formulations Bi & Gi Publishers, Verona Springer Verlag, London 1995