Osteo Support Plus

DELICIOUS AND CONVENIENT APPROACH TO SKELETAL HEALTH AND FUNCTION.

OSTEO SUPPORT PLUS is a unique combination of nutrients that act to support bone and joint health. Its critical nutrients include calcium, vitamins D and K2, magnesium and glucosamine HCL which help build and maintain strong bones. While the importance of vitamin and mineral supplementation for bone health is well-understood, many bone and joint formulas require multiple capsules. This unique powder formula is convenient to support patient compliance.

• New advanced combination formula for the support of bone and joint health.
• Innovative powdered beverage formula that is both great tasting and convenient.
• Provides essential bone and joint nutrients including calcium, magnesium, glucosamine, and vitamin K2 without the need for multiple capsules.

Serving Size: 1 Level Scoop (approx. 1 tsp)
Servings Per Container: 30

Active Ingredients:

• Calories 5
• Total carbohydrate 2 g
• Vitamin C (ascorbyl palmitate) 30 mg
• Vitamin D3 (cholecalciferol) 1,000 IU
• Vitamin K2 (menaquinone-7) 25 mcg
• Calcium (citrate/malate) 500 mg
• Magnesium (citrate) 250 mg
• Zinc (picolinate) 10 mg
• Copper (gluconate) 1 mg
• Manganese (aspartate) 1 mg
• Glucosamine HCl 500 mg
• Boron (citrate) 4 mg

Inactive Ingredients: Citric acid, natural flavor, xanthan gum, beet color, stevia leaf extract, silica.
Contains crustacean shellfish (from crab and shrimp).

Recommended Dosage:
As a dietary supplement, blend, shake or briskly stir one serving (one level scoop) into 4-6 oz. of water or beverage of choice one to two times per day or as directed by your healthcare professional.

CALCIUM (CITRATE/MALATE) are the calcium salts of citric and malic acid. These chelated forms of calcium are water-soluble compounds and therefore are highly absorbable and bioavailable. Calcium is the most abundant mineral in the body with the majority of body reserves being in the bones and teeth. Depletion of bone calcium occurs when blood levels of calcium are below optimal level. This repeated borrowing of bone calcium can lead to porous bone tissues and increases the risk for fractures and breakage. Although much of bone mass is acquired during adolescence and early adulthood, maintaining adequate intake of calcium throughout life can have profound effects on enhancing bone density. In studies of post-menopausal women, oral calcium supplementation has been shown to reduce bone loss and fractures.

MAGNESIUM (CITRATE) is a chelated form of magnesium and is also well absorbed and bioavailable. Magnesium is the fourth most abundant mineral in the body and supports numerous functions including enzyme regulation, calcium transport, and parathyroid hormone activity. Magnesium is also a critical component of the structure of the bone matrix, and deficiency is linked to an increase in bone brittleness and fracture risk. It is estimated that nearly 60% of the U.S. population does not meet the RDA for magnesium, leading to possible negative effects on cardiovascular, neurological, and bone health. Studies have shown that magnesium supplementation among post-menopausal women can support bone density and help prevent bone turnover.

VITAMIN K2 (MENAQUINONE-7) supports bone health with its essential role in modulation of aberrant calcium metabolism. Arterial calcification is a major risk factor for both cardiovascular disease and osteoporosis. Vitamin K2 has a unique role as a dependent cofactor for carboxylation of the human matrix GLA protein (MGP), a major inhibitor of arterial calcification. Vitamin K2 as menaquinone-7 has been shown effective for maintaining calcium balance by helping keep calcium in the bones and out of the vascular media.

GLUCOSAMINE HCL is one of several naturally occurring amino sugars that are necessary for the rebuilding and healthy maintenance of connective tissue, including tendons, ligaments, cartilage, and bone matrix. Increased age is associated with glycation of cartilage that reduces the production of proteoglycans involved as joint lubricants. Glucosamine is an essential component of proteoglycans and may be nutritionally required to re-establish proteoglycan levels. A meta-analysis of fifteen double-blind, placebo-controlled clinical trials revealed that glucosamine sulfate was superior to placebo in all fifteen studies. Patients receiving glucosamine sulfate have a gradual and progressive reduction in joint pain and tenderness, as well as improved range of motion and walking speed. Glucosamine HCl is stabilized with either sodium chloride or potassium chloride. Our glucosamine product is stabilized with potassium chloride to avoid an additional source of sodium for patients.

VITAMIN D (CHOLECALCIFEROL), according to various studies, has been linked to joint disorders and decreased bone density when serum levels are low. In addition, risk for disorder progression increases substantially with both low vitamin D intake and decreased serum levels.Studies also reveal that vitamin D provides immune and anti-inflammatory support. One researcher described vitamin D as a flexible bidirectional immunomodulator. The cytokines interleukin 1 (IL-1) and interleukin 2 (IL-2) appear favorably regulated under the influence of vitamin D.

References:

1. Abraham GE, Grewal H. A total dietary program emphasizing magnesium instead of calcium. Effect on the mineral density of calcaneous bone in postmenopausal women on hormonal therapy. J Reprod Med. 1990;35(5):503-7.
2. Aydin H, et al. Short-term oral magnesium supplementation suppresses bone turnover in postmenopausal women. Biological Trace Element Research. 2010 Feb;133(2):136-43. Epub 2009 Jun 2.
3. Heaney RP. Calcium, dairy products and osteoporosis. J Am Coll Nutr. 2000 Apr;19(2 Suppl):83S-99S.
4. DeLuca HF. Overview of general physiologic features and functions of vitamin D. Am J Clin Nutr. 2004 Dec;80(6 Suppl):1689S-96S.
5. Kaneki M, et al. Japanese fermented soybean food as the major determinant of the large geographic difference in circulating levels of vitamin K2: possible implications for hip-fracture risk. Nutrition. 2001 Apr;17(4):315-21.
6. Nielsen FH, Hunt CD, Mullen LM, Hunt JR. Effect of dietary boron on mineral, estrogen, and testosterone metabolism in postmenopausal women. FASEB J. 1987 Nov;1(5):394-7.
7. Qiu G, et al. Efficacy and safety of glucasamine sulfate versus ibuprofen in patients with knee osteoarthritis. Arzneimittelforschung. 1998;48(5):469-74.