OSTEOGENESIS

VITAMINS, MINERALS, AND BOTANICALS TO PROVIDE COMPREHENSIVE BONE DENSITY SUPPORT

• Bioavailable micronutrients to support bone building activity
• Specialty nutrients to support optimal calcium metabolism

OSTEOGENESIS & OSTEOGENESIS ES provide a comprehensive blend of ingredients to support the maintenance and development of healthy bones. Contrary to popular belief, bone health is not only dependent on proper mineral intake. Maintenance of bone density is also heavily reliant on the numerous body reactions that support the balance between bone resorption and remodeling. The nutrients and botanicals in OsteoGenesis and OsteoGenesis ES are designed to not only provide the building materials for healthy bones, but also to support the endogenous pathways that favor maintenance of healthy bone structure.

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OsteoGenesis™
Serving size:  3 capsules
Number of servings per container:  30

Amounts per serving:

• Calcium (citrate/malate) 300 mg
• Vitamin D3 (cholecalciferol) 100 IU
• Vitamin K1 100 mcg
• Vitamin K2 (menaquinone-7) 25 mcg
• Magnesium (glycinate, citrate) 300 mg
• Zinc (picolinate) 8 mg
• Copper (gluconate) 0.5 mg
• Manganese (aspartate) 0.5 mg
• Horsetail extract (Equisetum arvense, 4:1) 100 mg
• Boron (citrate) 2  mg
• Vanadium (amino acid chelate) 50 mcg

OTHER INGREDIENTS: Cellulose, silica.

Suggested Dose:  As a dietary supplement, take 1 capsules three times per day or as directed by your healthcare professional

OsteoGenesis E.S™
Serving size: 6 capsules
Number of servings per container:

Amounts per serving:

• Vitamin C (ascorbyl palmitate) 30 mg.
• Calcium (citrate/malate) 800 mg
• Vitamin D3 (cholecalciferol) 800 IU
• Vitamin K1 50 mcg
• Vitamin K2 (menaquinone-7) 40 mcg
• Magnesium (citrate, glycinate) 400 mg
• Zinc (picolinate)  10 mg
• Copper (gluconate)  1 mg
• Manganese (aspartate)  1 mg
• Horsetail extract (Equisetum arvense)(4:1)  50 mg
• Boron (citrate) 4 mg

OTHER INGREDIENTS: Cellulose, silica, rice flour.

Suggested Dose:  As a dietary supplement, take 1-3 capsules two times per day or as directed by your healthcare professional.

Please read the Rockwell Nutrition Blog  to read more on Calcium and Bone building.

CALCIUM (CITRATE/MALATE) are the calcium salts of citric and malic acid. These chelated forms of calcium are water-soluble compounds and therefore highly absorbable and bioavailable. Calcium is the most abundant mineral in the body, with the majority of body reserves being in the bones and teeth. Depletion of bone calcium occurs when blood levels of calcium are below optimal level. This repeated borrowing of bone calcium can lead to porous bone tissues and increase the risk for fractures and breakage. Although much of bone mass is acquired during adolescence and early adulthood, maintaining adequate intake of calcium throughout life can have profound effects on enhancing bone density. In studies of post-menopausal women, oral calcium supplementation has been shown to reduce bone loss and fractures.

MAGNESIUM (GLYCINATE/CITRATE) are chelated forms of magnesium and are also well absorbed and bioavailable. Magnesium is the fourth most abundant mineral in the body and supports numerous functions including enzyme regulation, calcium transport, and parathyroid hormone activity. Magnesium is also a critical component of the structure of the bone matrix, and deficiency is linked to an increase in bone brittleness and fracture risk. It is estimated that nearly 60% of the U.S. population does not meet the RDA for magnesium, leading to possible negative effects on cardiovascular, neurological, and bone health. Studies have shown that magnesium supplementation among post-menopausal women can support bone density and suppress bone turnover.

VITAMIN D3 (CHOLECALCIFEROL) is the biologically active form of vitamin D. Cholecalciferol is a pro-hormone that has multiple roles in maintaining bone mineralization and serum calcium levels. Active vitamin D induces proteins that serve to enhance calcium transport across intestinal mucosal cells. In response to low serum calcium, vitamin D also stimulates calcium reabsorption in the renal tubules to help maintain calcium levels.

VITAMIN K2 (MENAQUINONE-7) plays an essential role in modulation of aberrant calcium metabolism. Abnormal deposition of calcium in arteries and heart valves is a major risk factor for both cardiovascular disease and osteoporosis. Vitamin K2 is a dependent cofactor for carboxylation of the human matrix GLA protein (MGP), which is a major inhibitor of arterial calcification. Vitamin K2 as menaquinone-7 has been shown to be effective for maintaining calcium balance by helping keep calcium in the bones and out of the vascular media. Among Japanese populations with high dietary intakes of vitamin K2, reduced incidence of bone fractures and bone density issues has been observed.

BORON improves the metabolism of calcium, phosphorous, and magnesium. Boron supplementation has been shown to reduce urinary excretion of calcium and magnesium and support hormone balance in post-menopausal women.

HORSETAIL (EQUISETUM ARVENSE) is a natural organic source of water soluble colloidal silica. Silica has been shown to strengthen the bone matrix connective tissue by enhancing cross-linking of collagen strands. Aging and decline in estrogen levels can reduce absorption of silica, indicating that supplementation may be of benefit.

REFERENCES:

1. Abraham GE, Grewal H. A total dietary program emphasizing magnesium instead of calcium. Effect on the mineral density of calcaneous bone in postmenopausal women on hormonal therapy. J Reprod Med. 1990;35(5):503-507
2. Hasin, A. et al. Short-term oral magnesium supplementation suppresses bone turnover in postmenopausal women. Biological Trace Element Research. 0163-4984. June 02, 2009
3. Heaney RP. Calcium, dairy products and osteoporosis. J Am Coll Nutr. 2000;19(2 Suppl):83S-99S
4. Hector, F. Overview of general physiologic features and functions of vitamin D. Am J Clin Nutr. 2004; 80 (suppl) 1689S-96S
5. Kaneki M, et al. Japanese fermented soybean food as the major determinant of the large geographic difference in circulating levels of vitamin K2: possible implications for hip-fracture risk. Nutrition. 2001 Apr: 17(4):315-21
6. Maeda, H., et al., "Occurrence of dermatitis in rats fed a cholesterol diet containing field horsetail (Equisetum arvense L.)," J Nutr Sci Vitaminol (1997), 43(5):553-63
7. Nielsen FH, Hunt CD, Mullen LM, Hunt JR.Effect of dietary boron on mineral, estrogen, and testosterone metabolism in postmenopausal women. FASEB J. 1987 Nov;1(5):394-7.
8. Tucker KL, Hannan MT, Chen H, Cupples LA, Wilson PW, Kiel DP. Potassium, magnesium, and fruit and vegetable intakes are associated with greater bone mineral density in elderly men and women. Am J Clin Nutr. 1999;69(4):727-736 Nov;1(5):394-7.