Are there any nutrients that might help Pyridoxal 5? Phosphate work more effectively?
B-complex and magnesium increase the effectiveness of Pyridoxal 5?Phosphate.

Diabetes Protection
A test for glycosylated hemoglobin will show how long someone's body has been exposed to the tissue-damaging effect of high blood sugar. Higher readings of this blood marker correspond to a greater extent of diabetes-related cellular harm. Vitamin B6 reduces glycosylated hemoglobin, which suggests that the disease's cell damage decreases, too. Taking supplements helps stabilize blood sugar, encourages cells to metabolize blood glucose, and fights eye damage and vision loss from diabetic retinopathy. Regular use also lowers the level of xanthurenic acid, an injurious chemical by-product of a B6 deficiency that causes diabetes in lab animals.³

Heart Disease
Diabetes drastically raises the risk of heart disease and since B-6 improves blood sugar control, it is able to protect cardiovascular health. B-6 is one of the three B-complex nutrients (along with folic acid and vitamin B12) which reduces homocysteine, one of the most recognized heart risk factor whose elevated level in the blood corresponds to greater rates of strokes and heart attacks. A lack of vitamin B-6 also increases heart attack risk since without it, blood thickens and tends to clot and block off an artery. Vitamin B6 also acts as a diuretic, helping to reduce water retention and, as a result, lower high blood pressure. A Harvard study of fifteen thousand American physicians illustrated that the men with the lowest B6 levels had 50% more heart attacks than their better-nourished peers.³

Immune System Weakness
As we age, vitamin B6 is important in having a strong natural defense from viral and bacterial infections. A lack of vitamin B6 diminishes our number of T cells. People with AIDS need the nutrient in an amount far beyond what they could possibly obtain from food. Even when they eat what a conventional dietitian would consider an adequate amount, AIDS patients still have significant B6 deficiency.³

Hormone Disturbances
Women have a special need for vitamin B6, because it performs a vital role in maintaining a balance of female hormones and helping PMS. By helping to convert estradiol, a form of estrogen, into estriol, its least harmful and least carcinogenic form, B6 counteracts one cause of cancer in women. As a natural diuretic, the vitamin brings relief when premenstrual tension starts to flare.³

Pregnancy Related Problems
A woman requires more B6 when she is pregnant and when she is taking birth control pills. Both tend to deplete the body of pyridoxine. Restoring optimal levels of B-6 often alleviates the depression that sets in as a side effect of oral contraceptives.³ Pregnancy related nausea and vomiting are also greatly alleviated with vitamin B-6.