INFLAMAZYME and PAINX

Taken together, these two products offer a powerful combination for pain and inflammation reduction.

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INFLAMAZYME
Key therapeutic enzymes which have both a balanced inflammatory response and fibrinolytic effect while also providing circulatory and immune support.

SPECIALTY FORMULA FOR COMPREHENSIVE ANTI-INFLAMMATORY AND IMMUNE SUPPORT.
- Formula comprised of key therapeutic enzymes
- Ingredients have anti-inflammatory and fibrinolytic (anti-encapsulation) effect
- Additionally supports circulatory and immune function

PANCREATIN is a mixture of several digestive enzymes: protease, amylase and lipase produced by the pancreas. Protease enzymes break down proteins by catabolizing the peptide bonds between amino acids. Amylase breaks down starches and lipase digests triglycerides into fatty acids and glycerols.

BROMELAIN was introduced as a medicinal agent in 1957, and since that time over 400 scientific papers on its therapeutic applications have been released in these studies. Bromelain has been reported to exert a wide variety of beneficial effects, including reducing inflammation in cases of joint disease, sports injury or trauma, and preventing swelling after trauma or surgery.

PAPAIN, TRYPSIN AND ALPHA CHYMOTRYPSIN are proteolytic enzymes. Administration of proteolytic enzymes may speed the healing of injuries. Proteolytic enzymes have allowed athletes to return to performance sooner than control groups. Chymotrypsin, and trypsin have been shown to reduce edema and inflammation.

NATTOKINASE is created by the bacterial fermentation of soy beans from the bacterium Bacillus natto. Dr. Hiroyuki Sumi discovered this enzyme, The enzyme of enzymes. Nattokinase functions as a fibrinolytic. Daily use reduces the risk of thrombotic events that may otherwise threaten patients lives (CVA, MI PE, etc.). Nattokinase enhances normal circulation and oxygen perfusion to tissues.

SERRAPEPTASE is a proteolytic enzyme that has been shown to have anti-inflammatory, antiedemic and fibrinolytic activity. Serrapeptase provides benefits for pain reduction, reduction of viscosity of mucous, and breakdown of abnormal tissue such as scar tissue.

CELLULASE SUPPORTS carbohydrate digestion. When cellulose fibers are digested there is less fermentable substrate and less secondary fermentation inflammatory byproduct. Some reports show that cellulase digests the cell walls of intestinal yeast, reducing gut dysbiosis. Additionally cellulase can reduce allergic reactions by digesting cell wall components that can trigger allergic sensitivity.

SUPEROXIDE DISMUTASE (SOD) catalyzes the destruction of the O2- free radical. As such, it is an vitally important antioxidant and repairs cells and reduces the damage done to them by superoxide, the most common free radical in the body. Studies have shown that SOD acts as both an antioxidant and anti-inflammatory in the body

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PAIN X

A supplement designed to help reduce minor aches associated with acute or chronic conditions.
~ A blend of anti-inflammatory herbs and proteolytic enzymes to reduce inflammatory activity.
~ Offers immediate pain relief with minimal gastrointestinal side effects.

Broad-spectrum pain relief product with white willow bark, bromelain, ginger, and boswellia.

DL PHENYLALANINE (DLPA) has putative antidepressant and analgesic (pain relieving) properties. Pain reduction may occur by limiting enkephalin degradation by the enzyme carboxypeptidase A. The LPA portion acts as a precursor to the synthesis of norepinephrine and dopamine. This effect may explain DLPAs reputed antidepressant activities. DLPA is contraindicated in those with phenylketonuria, and those taking nonselective MAO inhibitors.

BOSWELLIA has been used in traditional Indian medicine for chronic rheumatic inflammation. Boswellic acids have been shown to inhibit 5-lipoxygenase, the enzyme in leukotriene biosynthesis. It is this property along with its ability to inhibit both the classical and alternative complement pathways that account for its anti-inflammatory properties.

CURCUMIN the yellow pigment from the plant Curcuma longa, has been used traditionally to treat sprains and inflammation. Studies show that curcumin inhibits leukotriene synthesis, platelet aggregation, and neutrophil inflammatory response, blocks activation of NF Kappa B, and promotes fibrinolysis. Curcumin may potentiate endogenous corticosteroids, thus having indirect anti-inflammatory actions as well. Curcumin was as effective as cortisone or phenylbutazone in models of acute inflammation, but only half as effective in chronic models. However, while phenylbutazone and cortisone are associated with significant toxicity, curcumin displayed virtually no toxicity.

BROMELAIN was introduced as a medicinal agent in 1957, and since that time over 400 scientific papers on its therapeutic applications have appeared. Bromelain has been reported in these studies to exert a wide variety of beneficial effects, including reducing inflammation in cases of joint disease, sports injury or trauma, and preventing swelling after trauma or surgery.

Bromelain selectively stimulates the production of the anti-inflammatory Prostaglandin E1 and inhibits the production of the pro-inflammatory Prostaglandin E2. NOTE: Bromelain may enhance the anticoagulant activity of such drugs as warfarin and aspirin.

WHITE WILLOW BARK (SALIX ALBA) is traditionally used to treat pain. The efficacy of this botanical, used therapeutically for 2000 years, is due mainly to the proportion of salicin present. The salicin, which is a precursor to salicylic acid, works as an antipyretic, antiphlogistic and as an analgesic. An extract of white willow tree bark is as effective as a common prescriptive drug for the treatment of low back pain. One study compared the efficacy of white willow bark extract to rofecoxib (Vioxx) in 228 randomly assigned individuals with low back pain treated for a period of 4 weeks. In all measures of pain relief White Willow Bark was found to be as effective as rofecoxib (Vioxx). Rheumatology (2001;40:1388-93)

• Anti-inflammatory
• Antipyretic
• Analgesic
• Hemostatic
• Antithelmintic

GUGGUL has been used traditionally for inflammation of the mouth and pharynx. Currently guggul is recommended for chronic inflammatory conditions.

BIOFLAVONOIDS have been shown to possess antioxidant, anti-inflammatory, anti-allergic, and vasoprotective actions. Hesperidin appears to inhibit phospholipase A2, lipoxygenase and cyclo-oxygenase inflammatory mediators as well as inhibit histamine release.

GINGER inhibits platelet thromboxane formation, lipoxygenase, Arachidonic acid metabolism, leukotriene and inflammatory prostaglandin production. Ginger has anti-inflammatory actions. In one small study, consisting of 10 patients, complaining of chronic muscular pain and discomfort, ginger relieved the pain and swelling in 100% of the patients. These patients were evaluated for periods ranging from 3 months to 2.5 years.

ROSEMARY has traditionally been recommended for muscular rheumatism. Rosemary also has antioxidant actions.

PAPAIN, TRYPSIN AND ALPHA CHYMOTRYPSIN are proteolytic enzymes. Administration of proteolytic enzymes may speed healing of injuries. Proteolytic enzymes have allowed athletes to return to performance sooner than control groups. Chymotrypsin, and trypsin have been shown to reduce edema and inflammation.

InflamaZyme
Serving Size 2 capsules
Servings Per Container 45
Amount Per Serving
Pancreatin 400 mg
Bromelain (3200 mcu/gm) 250 mg
Superoxide Dismutase (SOD) 100 mg
Cellulase 100 CU
Papain (2000 USP units/gm) 90 mg
Trypsin (2160 FIP unit) 72 mg
Nattokinase (20,000 FU/gm) 50 mg
Chymotrypsin (900 FIP unit) 3 mg
Serrapeptase (2,000,000 CDU/gm) 2 mg

SUGGESTED USE: As a dietary supplement, take 1-2 capsules between meals 3 times per day or as directed by your healthcare professional.

PAIN X
Serving Size 3 Capsules
Servings Per Container 30
Amount Per Serving
DL Phenylalanine 200mg
Boswellia PE (65% Boswellic acids) 200mg
Curcumin PE (95% Curcuminoids) 200mg
Bromelain 2,400 GDU 200mg
White Willow Bark PE 300mg
(15% Salicylic acid)
White Willow Bark 270mg
Guggul PE (2.5%) 100mg
Bioflavonoids (50%) 100mg
Ginger PE (5% gingerols) 100mg
Papain 100mg
Trypsin (1:75) 100mg
Rosemary PE (4:1) 100mg
Alpha Chymotrypsin (1:25) 3mg

PAIN X

SUGGESTED DOSE: As a dietary supplement, take 1-2 capsules without food three times per day or as directed by your healthcare professional.

INFLAMAZYME REFERENCES:
1. Cichoke AJ, Marty L. The use of proteolyticenzymes with soft tissue athletic injuries. Am Chiropractor October 1981, p. 32.
2. Gonzalez M.D., N.: Enzyme Therapy and Cancer.
3. Klein G., Kullich W., Schnitker J., Schwann H. Efficacy and tolerance of an oral enzyme combination in painful osteoarthritis of the hip. A double-blind, randomised study comparing oral enzymes with non-steroidal anti-inflammatory drugs. Clin Exp Rheumatol. 2006 Jan-Feb; 24(1): 25-30
4. Nakamura S., Hashimota Y., Mikami M., Yamanaka E, Soma T, Hino M, Azuma A, Kudoh S. Effect of the proteolytic enzyme serrapeptase in patients with chronic airway disease. Respirology. 2003 Sep; 8(3):316-20
5. Popiela T, Kulig J, Hanisch J, Bock PR. Influence of a complementary treatment with oral enzymes on patients with colorectal cancers--an epidemiological retrolective cohort study. Cancer Chemother Pharmacol. 2001 Jul;47 Suppl:S55-63. PMID: 11561874
6. Taraye JP. Lauressergues H. Advantages of a combination of proteolytic enzymes, flavonoids and ascorbic in comparison and non-steroidal inflammatory agents. Arzneim Forsch 27(1): 1144-49, 1977.

*These statements have not been evaluated by the Food and Drug Administration.
This product is not intended to diagnose, treat, cure, or prevent any disease.

PAIN X REFERENCES:
1. Ehrenpreis S. Pharmacology of enkephalinase inhibitors: animal and human studies. Acupunct Electrother Res. 1985; 10:203-208.
2. Walsh ND, Ramamurthy S. Schoenfeld L, Hoffman J. Analgesic effectiveness of D-phenylalanine in chronic pain patients. Arch Phys Med Rehabil. 1986; 67:436-439.
3. Webach, MR, Murray MT. Botanical Influences on Illness: A sourcebook of clinical research. Third Line Press, Tarzana, CA, 2000.
4. Rall B et al., Boswellic acids and protease activity (s. auch folgende Abstracts). In: PM 61 (Abstracts of 43rd Ann Congr): 105. 1995.
5. Singh GB, Singh S, Bani S. Anti-inflammatory actions of boswellic acids. Phytomedicine 3(1):81-5, 1996.
6. Srimal R, Dhawan B. Pharmacology of diferuloyl methane (curcumin), a non-steroidal anti-inflammatory agent. J Pharm Pharmac 25: 447-52, 1973.
7. Taussig S, Batkin S. Bromelain, the enzyme complex of pineapple (Ananas comosus) and its clinical application. An update. J Ethnopharmacol 22:191-203, 1988.
8. Taussig SJ. The mechanism of the physiological action of bromelain. Med Hypothesis 6:99-104, 1980.
9. Vellini M et al. Possible involvement of eicosanoids in the pharmacological action of bromelain. Arzneimittelforschung 36:110-12, 1986.
10. PDR for Herbal Medicines, Medical Economics Company, Montvale, New Jersey. 1998.
11. Emin JA, Oliveira AB, Lapa AJ. Pharmacological evaluation of the anti-inflammatory activity of a citrus bioflavonoid, hesperidin, and the isoflavonoids duartin and claussequinone in rats and mice. J Pharm Pharmacol. 46:118-122, 1994.
12. Srivastava KC and Mustafa T. Ginger (Zingiber officinale) in rheumatism and musculoskeletal disorders. Med Hypothesis 39:342-8, 1992.
13. Cichoke AJ, Marty L. The use of proteolytic enzymes with soft tissue athletic injuries. Am Chiropractor October 1981, p. 32.
14. Taraye JP, Lauressergues H. Advantages of a combination of proteolytic enzymes, flavonoids and ascorbic acid in comparison with non-steroidal inflammatory agents. Arzneim Forsch 27(1):1144-49, 1977.