Other Ingredients:  Dicalcium phosphate, cellulose, maltodextrin, silicon dioxide, magnesium stearate

Directions:
As a dietary supplement, take one to five capsules per day or as directed by your healthcare practitioner.

This product does not contain wheat, dairy, corn, artificial colors or flavors.

PS-DHA Conjugate:
Mimics the structure-function of the human PS to better activate your memory and mental performance

PS-DHA Conjugate = Greater DHA Availability
PS-DHA Conjugate – Better Performance
PS-DHA follows original form of PS and supported by most reliable scientific literature

Historic Overview
Phos-Serine DHA Supreme is a high quality soy-derived phosphatidylserine (PS) brain nutrient. PS is an essential constituent of brain membranes and an important player in brain-related biochemical pathways. This clinically-proven ingredient is nutritionally supplemented to help adults slow down and improve age-related decline in cognitive capabilities, such as memory, as described in tow qualified health claims, recently approved by the US-FDA[i]. PS may also benefit a variety of populations, from young to old, in regard to improving memory and learning abilities, as well as concentration, mood and stress. PS is traditionally supplemented by capsules and tablets and may also be supplemented through a variety of food applications.

Age-related Cognitive Decline Age-related deterioration of brain functions is a continuous process starting even in relatively young adults. This process dramatically affecting the quality of life of most of the elderly and adult populations in the modern age[ii]. Brain functions that are affected include memory, such as remembering names and numbers, and learning abilities. In more acute cases, this deterioration is manifested as dementia (e.g. Alzheimer’s disease (AD)). About 10% of people aged 65 or older have mild cognitive impairment, and nearly 15% of them develop AD each year (see Figure 1).

Scientific Background
PS and Brain
PS is a naturally occurring phospholipids, and it plays an important role in the normal functioning of the cell membranes. Human brain cell membranes are highly enriched with PS, as compared to other mammalian tissues. Nerve cells, in particular depend on healthy membrane function for normal neuro-transmitter metabolism and nerve signal transmission. PS levels in these tissues ensure the membranes fluidity and structure, hence their function. Furthermore, maintaining brain PS level was associated with normal and efficient signal transduction processes, efficient glucose consumption, and other biological pathways that are crucial to ensure normal and healthy cognitive and mental functions[iii iv v vi].

PS Clinical Evidence
PS has been thoroughly clinically tested and its daily supplementation has been show to have definite benefits in connection to brain functions[vii]. Age-associated memory impairment patients (AAMI), treated with PS, improved relative to the placebo treated patients on performance tests related to learning and memory tasks of daily life[viii]. In geriatric patients, PS significantly improved behavioral and cognitive parameters[ix]. Several multi-center, double-blind, placebo-controlled trials with AD subjects, suggest that PS improve cognitive performance also in demented patients [x xi]. A meta-analysis on eight intervention studies in 1,168 subjects, using the common parameters of cognition and memory, indicated highly significant improvements following PS regime, as compared to placebo and baseline values in both short- and long-term administration (3 and 6 months, respectively)[xii].

In the past, PS was extracted from bovine brains but currently, due to concerns about the possible transfer of infectious diseases, PS is obtained from enzymatically modified soybean lecithin (Soy-PS). Soy-PS has been commercially available as a dietary supplement all over the world since the early 1990’s.

Soy-PS Clinical Evidence
Animal models::  Soy-PS has been proven to exert similar behavioral and cognitive effects to those observed for bovine brain cortex-PS (BC-PS). Administration of Soy-PS to rats has shown to antagonize the amnesic effects of scopolamine, as did BC-PS[xiii]. Comparable effects on cognition were also observed in a pre-clinical study evaluating the cognition-enhancing properties of Soy-PS and BC-PS in three different behavioral tests[xiv]. In a mice model, oral administration of Soy-PS was found to ameliorate impaired learning behavior[xv].

Clinical Studies::  In human clinical studies[xvi xvii xviii], Soy-PS supplementation has been shown to assist against the symptoms of AAMI, including reducing the risk of dementia and cognitive dysfunction. Moreover, it has been found that Soy-PS may “turn back” the aging process. Following 12 weeks of supplementation with 300 mg/day of Soy-PS, cognitive tests have shown strong effects of Soy-PS, especially in regard to the capacity to learn and remember names. The “reversal” of the aging process amounted to nearly 14 years (see Figure 2). Improvements were exhibited in other capacities as well, including learning and remembering written information, recognition of persons, and memory of numbers.

Additionally, Soy-PS may also benefit younger populations, including young adults seeking to maintain a sharp mind and control stress as well as students seeking improvement of their learning abilities and performance [xix xx].

PS Recommended Daily Dosage
The common intake of PS, based on PS intakes utilized in clinical trials and covered in the scientific and clinical literature, ranges between 100 mg and 300 mg per day. Accordingly, 100 mg/day of Soy-PS is the minimal recommended effective daily dosage. However, for more immediate results, 4 weeks of 300 mg/day supplementation followed by 100 mg/day supplementation may be recommended.

PhosSerine-DHA Supreme™ is the first fully conjugated PhosphatidylSerine-DHA supplement. It is uniquely able to nourish and support brain wellness, memory and concentration.

PS Recommended Daily Dosage
The common intake of PS, based on PS intakes utilized in clinical trials and covered in the scientific and clinical literature, ranges between 100 mg and 300 mg per day. Accordingly, 100 mg/day of Soy-PS is the minimal recommended effective daily dosage. However, for more immediate results, 4 weeks of 300 mg/day supplementation followed by 100 mg/day supplementation may be recommended.