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Home > Health Concerns > Other Health Concerns > Brain Wellness (Memory)

Phosphatidyl Serine Capsules by Douglas Labs

30 capsules
Phosphatidyl Serine Capsules by Douglas Labs
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$43.10
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    Phosphatidyl Serine

    Phosphatidylserine is a naturally occurring phospholipid nutrient which can help improve memory impairment and cognitive function.

    Phosphatidylserine capsules provided by Douglas Laboratories contain 500 mg of plant-derived (soybean) phospholipids supplying 100 mg of phosphatidylserine (PS). Until recently, PS was only available as a very expensive product derived from bovine sources, with microbiological safety problems. New technology has made it possible to concentrate this important brain nutrient from soybean lecithin, a safe and well-recognized source of phosphatidylserine

    Serving Size: 1capsule
    Servings Per Container: 30

    Active Ingredients:

      334 mg of LECI-PS providing:
    • Phospholipid Complex as soy phospholipids:
    • Phosphatidylserine.......................................100 mg
    • Phosphatidylcholine.......................................50 mg
    • Phosphatidylethanolamine .............................43 mg
    • Phosphatidylinositol ......................................20 mg
    • Fatty Acids Profile:
    • Linoleic Acid ...............................................110 mg
    • Linolenic Acid ...............................................10 mg
    • Oleic Acid......................................................20 mg
    • Stearic Acid ...................................................10 mg
    • Palmitic Acid .................................................35 mg
    • Minerals:
    • Phosphorus ....................................................15 mg
    • Potassium.........................................................5 mg

    Inactive Ingredients: Cellulose, Gelatin, Silica, Stearate, Vegetable stearate

    Recommended Dosage:
    Adults take 1 capsule daily or as directed by physician.

    Store in a cool, dry place, away from direct light. Keep out of reach of children.

    Read customer questions and answers about Brain Health and Memory on our blog.

    Functions

    Phosphatidylserine (PS), a phospholipid nutrient, is active in cell membranes and is the major acidic phospholipid component in the membranes of the brain. Membranes are the working surfaces of every cell, carrying out the essential functions of cellular communication and hormonal signal transduction. Nerve cells, in particular, depend on healthy membrane function for normal neurotransmitter metabolism and nerve signal transmission.

    PS occupies a crucial role in many of these membraneassociated nerve cell processes. The fundamental function of PS is to help maintain proper membrane fluidity, which has major implications on most membrane functions.

    In the brain, PS helps maintain normal capacity for acetylcholine release and thus is important to the cholinergic neurotransmitter system. PS has similar functions in the dopamine, noradrenaline and serotonin dependent neurotransmitter systems. It is also needed for sodium and potassium transport via its influence on ATPase activity.

    PS assists in maintaining adequate glucose utilization in the brain. Glucose is the preferred energy substrate for nerve cells which, unlike other cells, are unable to use fatty acids or proteins for energy production. Brain glucose utilization, an indicator of brain activity, often declines during aging.

    Another related function of PS is its role in controlling the normal balance of stress hormones. PS is involved in the body?s response to counterbalance the excessive release of adrenocorticotrophic hormone (ACTH) and adrenaline after physical stress from exercise, while supporting normal growth hormone release at the same time.

    Dietary PS is efficiently and rapidly absorbed in the intestine, taken up into the blood, and readily crosses the blood-brain barrier to reach the nerve cells of the brain.

    References:

    1. Allegro L, Favaretto V, Ziliotto G. Oral phosphatidylserine in elderly patients with cognitive deterioration , an open study. Clinical Trials Journal 1987;24:104-108.
    2. Brambilla F, Maggioni M, Cenacchi T, Sacerdote P, Panerai AR. Tlymphocyte proliferative response to mitogen stimulation in elderly depressed patients. J Affect Disord 1995;36:51-6.
    3. Brambilla F, Maggioni M, Panerai AE, Sacerdote P, Cenacchi T. Beta-endorphin concentration in peripheral blood mononuclear cells of elderly depressed patients--effects of phosphatidylserine therapy. Neuropsychobiology 1996;34:18-21.
    4. Cenacchi T, Baggio C, Palin E. Human tolerability of oral phosphatidylserine assessed through laboratory examinations. CLIN TRIALS J 1987;24:125-130.
    5. Cenacchi T, Bertoldin T, Farina C, Fiori MG, Crepaldi G. Cognitive decline in the elderly: a double-blind, placebo-controlled multicenter study on efficacy of phosphatidylserine administration. Aging (Milano) 1993;5:123-33.
    6. Crook T, Petrie W, Wells C, Massari DC. Effects of phosphatidylserine in Alzheimer's disease. Psychopharmacol Bull 1992;28:61-6.
    7. Crook TH, Tinklenberg J, Yesavage J, Petrie W, Nunzi MG, Massari DC. Effects of phosphatidylserine in age-associated memory impairment. Neurology 1991;41:644-9.
    8. Delwaide PJ, Gyselynck-Mambourg AM, Hurlet A, Ylieff M.
    9. Double-blind randomized controlled study of phosphatidylserine in senile demented patients. Acta Neurol Scand 1986;73:136-40.
    10. Drago F, Spadaro F, D'Agata V, Valerio C, Grassi M, Mauceri F, Pennisi G, Scapagnini U. Protective action of phosphatidylserine on stress-induced behavioral and autonomic changes in aged rats. Neurobiol Aging 1991;12:437-40.
    11. Engel RR, Satzger W, Gunther W, Kathmann N, Bove D, Gerke S, Munch U, Hippius H. Double-blind cross-over study of phosphatidylserine vs. placebo in patients with early dementia of the Alzheimer type. Eur Neuropsychopharmacol 1992;2:149-55.
    12. Funfgeld EW, Baggen M, Nedwidek P, Richstein B, Mistlberger G. Double-blind study with phosphatidylserine (PS) in parkinsonian patients with senile dementia of Alzheimer's type (SDAT). Prog Clin Biol Res 1989;317:1235-46.
    13. Furushiro M, Suzuki S, Shishido Y, Sakai M, Yamatoya H, Kudo S, Hashimoto S, Yokokura T. Effects of oral administration of soybean lecithin transphosphatidylated phosphatidylserine on impaired learning of passive avoidance in mice. Jpn J Pharmacol 1997;75:447-50.
    14. Gianotti C, Porta A, De Graan PN, Oestreicher AB, Nunzi MG. B- 50/GAP-43 phosphorylation in hippocampal slices from aged rats: effects of phosphatidylserine administration. Neurobiol Aging 1993;14:401-6.
    15. Granata Q, Di Michele J. Phosphatidylserine in elderly patients an open trial. Clinical Trials Journal 1987;24:99-103.
    16. Heiss WD, Kessler J, Mielke R, Szelies B, Herholz K. Long-term effects of phosphatidylserine, pyritinol, and cognitive training in
    17. Alzheimer's disease. A neuropsychological, EEG, and PET investigation. Dementia 1994;5:88-98.
    18. Khalsa DS. Integrated medicine and the prevention and reversal of memory loss. Altern Ther Health Med 1998;4:38-43.
    19. Kidd PM. A review of nutrients and botanicals in the integrative management of cognitive dysfunction. Altern Med Rev 1999;4:144- 61.
    20. Maggioni M, Picotti GB, Bondiolotti GP, Panerai A, Cenacchi T, Nobile P, Brambilla F. Effects of phosphatidylserine therapy in geriatric patients with depressive disorders. Acta Psychiatr Scand 1990;81:265-70.
    21. Ransmayr G, Ploerer S, Gerstenbrand F, Bauer G. Double-blind placebo-controlled trial of phosphatidylserine in patients with arteriosclerotic encephalopathy. Clinical Trials Journal 1987;24:62- 72.
    22. Sakai M, Yamatoya H, Kudo S. Pharmacological effects of phosphatidylserine enzymatically synthesized from soybean lecithin on brain functions in rodents. J Nutr Sci Vitaminol (Tokyo) 1996;42:47-54.
    23. Sinforiani E, Agostinis C, Merlo P, Gualtieri S, Mauri. Cognitive decline in ageing brain therapeutic approach with phosphatidylserine. Clinical Trials Journal 1987;24:115-124.
    24. Villardita C, Grioli S, Salmeri G, Nicoletti F, Pennisi G. Multicenter clinical trial of brain phosphatidylserine in elderly patients with intellectual deterioration. Clinical Trials Journal 1987;24:84-93.


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