Pregnenolone 30 mg

Pregnenolone, a natural precursor to over 150 steroid hormones, helps support the immune system, mood and memory.

Pregnenolone, 3-alpha-hydroxy-5-beta-pregnen-20-one, is a natural steroid hormone produced in the body from cholesterol. It has been described as the ?Grandmother of all Steroid Hormones,? since all steroid hormones, over 150 of them, are derived from pregnenolone. Pregnenolone has been linked with positive support of the immune system, mood and memory. In the body, it takes one or two metabolic pathways, converting to DHEA and/or progesterone. It is likely that the body will convert pregnenolone appropriately, according to its needs. Studies show that the body makes 60% less of this hormone at age 75 than it does at age 35.

Serving Size: 1 capsule
Servings Per Container: 60

Active Ingredients:

• pregnenolone (3-alpha-hydroxy-5-beta-pregnen-20-one) 30mg. (hypo-allergenic plant fiber added to complete capsule volume requirement)

Inactive Ingredients: 

Recommended Dosage:
1 vegetarian capsule per day, with a meal.

Warning: Not for use by persons under the age of 18. Do not use if pregnant or nursing.

Consult a physician or licensed qualified healthcare professional before using this product if you have, or have a family history of prostate cancer, prostate enlargement, heart disease, low "good" cholesterol (HDL), or if you are using any other dietary supplement, prescription drug, or over-the-counter drug.

Do not exceed the recommended serving. Exceeding the recommended serving may cause serious adverse health effects.

Possible side effects include acne, hair loss, hair growth on the face (in women), aggressiveness, irritability, and increased levels of estrogen.

Discontinue use and call a physician or licensed qualified health care professional immediately if you experience rapid heart beat, dizziness, blurred vision, or other similar symptoms.

KEEP OUT OF REACH OF CHILDREN .

Are There Any Potential Side Effects Or Precautions?
When taken at higher levels, irritability, over-stimulation and fatigue have been observed. Due to its effects on the GABA receptor in the central nervous system, supplementation with pregnenolone could cause problems in people with a history of seizures. This product is not recommended for use by pregnant or lactating women.

Are There Any Potential Drug Interactions?
Pregnenolone may inhibit drugs used to increase GABA activity (e.g., Neurontin); these drugs are frequently used in the treatment of epilepsy and depression.

Read customer questions and answers about Immune Support on our blog.

What Is It?
Pregnenolone, 3-alpha-hydroxy-5-beta-pregnen-20-one, is precursor to over 150 steroid hormones and is produced naturally in the body from cholesterol.

Uses For Pregnenolone

• Memory Support: Animal studies have reported that pregnenolone may help to enhance memory by modulating N-methyl-D-aspartate (NMDA) and gamma aminobutyrate (GABA) (A) receptor activity in the brain. One study suggested that pregnenolone helped promote post-training task learning and memory.
• Immune Health: One study indicated that the 7-hydroxy metaboites from pregnenolone may help promote healthy immune system response.
• Mood Support: Pregnenolone has been reported to help promote feelings of emotional well-being. One study suggested that pregnenolone supported mood and feelings of motivation by mediating dopamine release.

What Is The Source?
The compound diosgenin is extracted from wild yam and undergoes a proprietary synthetic process to develop the pregnenolone compound. The human body cannot metabolize wild yam into pregnenolone. This process can only take place in a laboratory. Pure Encapsulations Pregnenolone also contains hypoallergenic plant fiber (pine cellulose).

References:

1. Mathis C, Vogel E, Cagniard B, Criscuolo F, Ungerer A. The neurosteroid pregnenolone sulfate blocks deficits induced by a competitive NMDA antagonist in active avoidance and lever-press learning tasks in mice. Neuropharmacology 1996;35(8):1057-1064.
2. Bowlby MR. Pregnenolone sulfate potentiation of N-methyl-D-aspartate receptor channels in hippocampal neurons. Mol Pharmacol 1993 May;43(5):813-819.
3. Flood JF, Morley JE, Roberts E. Pregnenolone sulfate enhances posttraining memory processes when injected in very low doses into limbic system structures: the amygdala is by far the most sensitive. Proc Natl Acad Sci U S A 1995 Nov 7;92(23):10806-10810.
4. Morfin R, Courchay G. Pregnenolone and dehydroepiandrosterone as precursors of native 7-hydroxylated metabolites which increase the immune response in mice. J Steroid Biochem Mol Biol 1994 Jul;50(1-2):91-100.
5. Barrot M, Vallee M, Gingras MA, Le Moal M, Mayo W, Piazza PV. The neurosteroid pregnenolone sulphate increases dopamine release and the dopaminergic response to morphine in the rat nucleus accumbens. Eur J Neurosci 1999 Oct;11(10):3757-60.
6. Healthnotes Clinical Essentials. Copyright 2003. Healthnotes, Inc