Nordic Naturals ProDHA formula is high concentration DHA supplement, encapsulated in small, easy-to-swallow soft gelatin capsules. Nordic Naturals ProDHA is a delicious way to ensure adequate intake of the essential brain nutrient, DHA.
Serving Size:˙˙2 soft gels Servings Per Container:˙˙45 Amount Per Serving:
Calories.......9
Calories from fat.......9
Total fat.......1.0 g
Saturated fat.......0 g
Trans fat.......0 g
Vitamin E (d-alpha tocopherol).......15 IU
Omega-3s:
DHA (Docosahexaenoic acid).......450 mg
EPA (Eicosapentaenoic acid).......90 mg
Other Omega-3s.......40 mg
Total Omega-3s.......580 mg
Oleic acid (Omega-9).......24 mg
Less than 5 mg of cholesterol per serving.
Other Ingredients:˙˙Purified deep sea fish oil (from anchovies and sardines), soft gel capsule (gelatin, water, glycerin), d-alpha tocopherol, rosemary extract.
Recommended Use: Two softgels daily with food, or as directed by your healthcare professional or pharmacist.
Store in a cool, dry place away from sunlight. Do not take if tamper evident seal is broken or missing. Keep out of reach of children.
Warning: Consult with your physician before using this product if you are pregnant, diabetic, allergic to iodine, using blood thinners, or anticipate surgery.
May contain traces of soy or derivatives.
No gluten, yeast, milk derivatives, artificial colors or flavors.
DHA, a natural component of Omega-3 fish oil, provides nutritional support for the brain and nervous system.* All Nordic Naturals products surpass all national and international pharmaceutical standards for freshness and purity, and are free from heavy metals, dioxins, and PCBs. Every batch is third party tested to guarantee exceptional freshness and purity levels.
Read Customer questions and answers about Pregnancy in our FAQ.
Nutrient Support DHA (Docosahexaenoic Acid) is a polyunsaturated fatty acid, and is an essential building block of brain & nerve tissue. DHA, cannot be synthesized by the body, and therefore must be obtained by a diet high in deep-sea cold water fish.
DHA, which constitutes approximately 40% of the brain, supports brain development during the last trimester of pregnancy when the unborn child?s demand for neurological growth increases greatly. If added to the mother?s diet, it can help prevent the depletion of the mother?s store of DHA, and support the developing baby?s essential fatty acid needs.
Currently, the proposed Adequate Intake of DHA for pregnant and lactating woman is 300 mg. per day. (ISSFAL)*
Clinical investigations are continually carried out showing the importance of DHA and Omega-3 fatty acids in maintaining optimal health.
Why Take DHA? What is DHA? Docosahexaenoic acid (DHA) is a long-chain polyunsaturated omega-3 essential fatty acid. Omega-3 fatty acids (along with omega-6s) are "essential" fatty acids because humans are unable to synthesize them de novo, meaning that they must be consumed via diet to meet the body's needs. DHA is found throughout the body, and the brain in particular is very rich in DHA, where it increases membrane fluidity, promotes neurite (axonal and dendritic) outgrowth, and has many other functions.
Protection Against Stress: One of the apparent benefits of DHA is to protect against the harmful effects of stress. Supplementation with DHA has been shown to reduce elevations in aggression1,[2] and hostility[3] in response to psychological stress, and may have contributed to a reduction in antisocial behaviors among prisoners given dietary supplements[4]. In addition, DHA may help to protect against the increased risk of heart attack associated with stress5 and depression6.
Learning and Cognition: Proper nutrition with omega-3s may also be important to learning ability. Dietary omega-3 deficiencies in rodents are reflected in the brain, and have been shown to impair learning ability.[7,8,9] In humans, low levels of DHA in the body and low fish consumption have been established as risk factors for age-associated cognitive impairments[10], especially Alzheimer's Disease[11,12]. One study even found that omega-3 treatment improved Alzheimer's Disease-induced cognitive impairments for six months.[13]
Pregnancy and Lactation: During pregnancy and lactation, proper nutrition with long chain omega-3s appears to be especially important for the health of both the mother and child. Inadequate maternal omega-3 intake during pregnancy is a risk factor for premature birth and low birth weight[14,15], diabetes[16], and postpartum depression[17]. DHA also appears to be very important to infants' visual and cognitive development.[18,19] A recent study showed that children whose mothers had taken cod liver oil during pregnancy and lactation had higher IQ's at age 4 than those whose mothers had taken a placebo.[20] However, it is also important to note that exposure to environmental toxins found in certain kinds of fish, are associated with increased risk for low birth weight.[21] It is therefore crucial for expecting mothers to seek out a molecularly distilled source of omega-3 polyunsaturated fatty acids.
Alcohol's Damaging Effects: Another circumstance that increases the body's need for DHA is elevated consumption of alcohol. Although studies have not been conducted in humans, alcohol has been shown to reduce DHA levels in brain and retina[22,23], as well as liver, plasma, and red blood cells[24] in animal models of alcoholism. Low essential fatty acid intake among alcoholics may thus contribute to risk of developing liver disease[25] and to diminished retinal function[22], suggesting that frequent alcohol consumers may have a high dietary requirement for omega-3s.
Summary: Dietary DHA appears to be important for everyone to protect against the effects of stress and to promote optimal cognitive abilities. Pregnant and lactating women, as well as frequent alcohol consumers, may require additional dietary intake in order to meet their body's increased needs for DHA.
Product Name:
ProDHA
Oil origin:
Arctic Norway
Fish used:
cod
Oceans harvested in:
Arctic Ocean
Risk of fish decline or ocean hotspots in harvesting area:
none
Molecular enzymatic distillation:
yes
Concentration EPA/DHA:
1/5
Peroxide value:
1.0
Heavy metal*
not detected
Dioxins**
not detected
Nitrogen encapsulation:
yes
Patent protected:
yes
Used for clinical studies:
yes
* tested down to 25 ppb (particles per billion) ** tested down to 0.4 ppt (particles per trillion)
* International Society for the Study of Fatty Acids and Lipids.
Hamazaki T, Sawazaki S, Nagasawa T, Nagao Y, Kanagawa Y, Yazawa K. Administration of docosahexaenoic acid influences behavior and plasma catecholamine levels at times of psychological stress. Lipids. 1999;34 Suppl:S33-7.
Hamazaki T, Sawazaki S, Itomura M, Asaoka E, Nagao Y, Nishimura N, Yazawa K, Kuwamori T, Kobayashi M. The effect of docosahexaenoic acid on aggression in young adults. A placebo-controlled double-blind study. J Clin Invest. 1996 Feb 15;97(4):1129-33.
Hamazaki T, Itomura M, Sawazaki S, Nagao Y. Anti-stress effects of DHA. Biofactors. 2000;13(1-4):41-5.
Gesch CB, Hammond SM, Hampson SE, Eves A, Crowder MJ. Influence of supplementary vitamins, minerals and essential fatty acids on the antisocial behaviour of young adult prisoners. Randomised, placebo-controlled trial. Br J Psychiatry. 2002 Jul;181:22-8.
Rousseau D, Moreau D, Raederstorff D, Sergiel JP, Rupp H, Muggli R, Grynberg A. Is a dietary n-3 fatty acid supplement able to influence the cardiac effect of the psychological stress? Mol Cell Biochem. 1998 Jan;178(1-2):353- 66.
Hibbeln JR and Makino KK. (2002). Omega-3 fats in depressive disorders and violence: The context of evolution and cardiovascular health. In Skinner E.R. (Ed.) Brain Lipids in Biological Psychiatry (pp. 67-110). Elsevier Science B.V., New York.
Carrie I, Smirnova M, Clement M, DE JD, Frances H, Bourre JM. Docosahexaenoic acid-rich phospholipid supplementation: effect on behavior, learning ability, and retinal function in control and n-3 polyunsaturated fatty acid deficient old mice. Nutr Neurosci. 2002 Feb;5(1):43-52.
Catalan J, Moriguchi T, Slotnick B, Murthy M, Greiner RS, Salem N Jr. Cognitive deficits in docosahexaenoic aciddeficient rats. Behav Neurosci. 2002 Dec;116(6):1022-31.
Moriguchi T, Greiner RS, Salem N Jr. Behavioral deficits associated with dietary induction of decreased brain docosahexaenoic acid concentration. J Neurochem. 2000 Dec;75(6):2563-73.
Conquer JA, Tierney MC, Zecevic J, Bettger WJ, Fisher RH. Fatty acid analysis of blood plasma of patients with Alzheimer's disease, other types of dementia, and cognitive impairment. Lipids. 2000 Dec;35(12):1305-12.
Cooper J. Dietary lipids in the aetiology of Alzheimer's disease: implications for therapy. Drugs Aging. 2003;20(6):399-418.
Tully AM, Roche HM, Doyle R, Fallon C, Bruce I, Lawlor B, Coakley D, Gibney MJ. Low serum cholesteryl esterdocosahexaenoic acid levels in Alzheimer's disease: a case-control study. Br J Nutr. 2003 Apr;89(4):483-90.
Otsuka M. [Analysis of dietary factors in Alzheimer's disease: clinical use of nutritional intervention for prevention and treatment of dementia] Nippon Ronen Igakkai Zasshi. 2000 Dec;37(12):970-3. Japanese.
Allen KG, Harris MA. The role of n-3 fatty acids in gestation and parturition. Exp Biol Med (Maywood). 2001 Jun;226(6):498-506.
Olsen SF, Secher NJ, Tabor A, Weber T, Walker JJ, Gluud C. Randomised clinical trials of fish oil supplementation in high risk pregnancies. Fish Oil Trials In Pregnancy (FOTIP) Team. BJOG. 2000 Mar;107(3):382-95.
Stene LC, Ulriksen J, Magnus P, Joner G. Use of cod liver oil during pregnancy associated with lower risk of Type I diabetes in the offspring. Diabetologia. 2000 Sep;43(9):1093-8.
Hibbeln JR. Seafood consumption, the DHA content of mothers' milk and prevalence rates of postpartum depression: a cross-national, ecological analysis. J Affect Disord. 2002 May;69(1-3):15-29.
Larque E, Demmelmair H, Koletzko B. Perinatal supply and metabolism of long-chain polyunsaturated fatty acids: importance for the early development of the nervous system. Ann N Y Acad Sci. 2002 Jun;967:299-310.
Helland IB, Smith L, Saarem K, Saugstad OD, Drevon CA. Maternal supple-mentation with very-long-chain n-3 fatty acids during pregnancy and lactation augments children's IQ at 4 years of age. Pediatrics. 2003 Jan;111(1):e39-44.
Rylander L, Stromberg U, Hagmar L. Preterm birth and intra-uterine growth retardation among children of women with schizophrenia. Br J Psychiatry. 1999 Sep;175:239-45.
Pawlosky RJ, Bacher J, Salem N Jr. Ethanol consumption alters electroretinograms and depletes neural tissues of docosahexaenoic acid in rhesus monkeys: nutritional consequences of a low n-3 fatty acid diet. Alcohol Clin Exp Res. 2001 Dec;25(12):1758-65.
Pawlosky RJ, Salem N Jr. Ethanol exposure causes a decrease in docosahexaenoic acid and an increase in docosapentaenoic acid in feline brains and retinas. Am J Clin Nutr. 1995 Jun;61(6):1284-9.
Pawlosky RJ, Salem N Jr. Alcohol consumption in rhesus monkeys depletes tissues of polyunsaturated fatty acids and alters essential fatty acid metabolism. Alcohol Clin Exp Res. 1999 Feb;23(2):311-7.
Pawlosky RJ, Flynn BM, Salem N Jr. The effects of low dietary levels of polyunsaturates on alcohol-induced liver disease in rhesus monkeys. Hepatology. 1997 Dec;26(6):1386-92.
Average Rating
Customer Reviews
ProDHA
1/13/2011
Reviewed by Susan from Spring Hill, FL.
I have been pleased with the product and the service.
could have been better...
4/21/2010
Reviewed by Julia from New Brunswick, NJ.
Generally, I am happy with this company, however, this product upsets my stomach. Don't know why but it does...