Bio-identical hormones have the same chemical structure as hormones that are made by the human body. The key to natural or bio-identical versus synthetic is the molecular structure of the hormone. In order for a replacement hormone to fully replicate the function of hormones that were naturally produced and present in the human body, the chemical structure must exactly match the original.
The prevalent effect of Estriol is displayed at the skins epithelial surface. No generalized or systemic side effects have been noted and no side effects on the endometrial uterine lining have been noted. Furthermore, Estriol is the biologically weaker estrogen; and mainly epidermotropic properties of Estriol have been described in the skin.
“Both Estriol and Estradiol treatment induced significant increases of collagen fibers and striking increases of collagen III. These findings support the role that estrogens play in the dermis and may serve as an explanation for the clinical observations of increased firmness and significantly less wrinkling during treatment.” – International Journal of Dermatology 1996
“Estrogen deficiency in an important factor in skin aging in premenopausal women, topical treatment reverses some of the changes in aging skin.” - International Journal of Pharmaceutical Compounding. Aug. 1998
“So far estrogen compounds, and in particular Estriol, represents a new and promising therapeutic approach towards skin aging in premenopausal women.” – International Journal of Dermatology 1996
“After treatment for 6 months, elasticity and firmness of the skin markedly improved and wrinkle depth and pore size had decreased by 61% to 100%. Furthermore, skin moisture had increased and the measurement of wrinkles revealed significant or even highly significant decreases in wrinkle depth.” - International Journal of Dermatology 1996.