Seacure® is a pre-digested prime quality lean white fish protein concentrate from the deep unpolluted ocean waters. This whole fish concentrate has been found to have very healing properties, especially on the gastro intestinal tract and for intestinal permeability concerns.

Benefits of Seacure Include:

• IBS (Irritable Bowel)
• Leaky Gut
• Intestinal Integrity
• Immune System
• Promotes Healing

Each Capsule Contains:

• Proprietary Whitefish Concentrate…500mg

*A concentrate of nearly 100% assimilable nutrients derived from the natural biological pre-digestion of prime quality lean white fish harvested from deep unpolluted ocean waters. Digestible natural flavoring added which is rosemary. Fish source is Pacific Whiting (Merluccius productus) with occasional Pollock.

Suggested Use: As a dietary supplement, adults take six capsules of Seacure daily.

Should I refrigerate Seacure?
Yes. For best results Seacure® should be refrigerated after opening. This helps prevent "fishy" smell.

Dietary Bioactive Peptides In Maintaining Intestinal Integrity And Function
Paul D Thomas DO, Trent W Nichols MD, Angie Angstadt, Center for Nutrition and Digestive Disorders, Hanover, PA
ABSTRACT (Am J Gastroenterol. 2001;96(9):S311.)

Dietary peptides are known to have biological importance beyond their nutritive value as protein, influencing structural, hormonal, immune, and neurological functions. Alterations in the state of phosphorylation of the tight junction (TJ) protein occludin in the colonic epithelia of Crohn’s and UC patients have been demonstrated. Protein balance studies performed in patients with IBD indicate better nitrogen balance with peptide-based diets than with whole food diets, which are in turn better than amino acid-based diets; however, no studies have examined the use of supplemental peptides in improving gut epithelial permeability and associated symptom relief. Twenty patients assessed to have gut hyperpermeability by a urine test utilizing lactulose to mannitol ratio were given either 3g per day of a peptide supplement from hydrolyzed fish protein or a control for 6 weeks, followed by a second permeability test and symptom assessment scoring. Preliminary results with the first 15 patients show trends toward improvement in both symptom assessment and intestinal permeability scoring in test patients versus control patients. These particular peptides appear to act as trophic factors that help heal the lining of the gut and may energize TJ via increased protein synthesis.

References:

1. Speck WT, Stein AB, Rosenkranz HS. Mutagenicity of metronidazole: Presence of several active metabolites in human urine. J Natl Cancer Inst. 1976;56:283.
2. Han PD, Burke A, Baldassano RN, et al. Nutrition and inflammatory bowel disease. Gastroenterology Clinics. 1999;28(2):423-43.
3. Pfau PR, Rombeau JL. Advances in gastroenterology: Nutrition. Medical Clinics of North America. 2000;84(5).
4. O’Morain C, Segal AW, Levi AJ. Elemental diet as primary treatment of acute Crohn’s disease: A controlled trial. Br Med J. 1984;288:1859-62.
5. Belluzzi A, Brignola C, Campieri M, et al. Effect of an enteric-coated fish-oil preparation on relapses in Crohn’s disease. NEJM. 1996;334(24):1557-60.
6. Roberts PR, Zaloga GP. Dietary bioactive peptides. New Horizons. 1994;2(2):237-43.
7. Poullain MG, Cezard JP, Roger L, et al. Effect of whey proteins, their oligopeptide hydrosylates and free amino acid mixtures on growth and nitrogen retention in fed and starved rats. JPEN. 1989;13:382.
8. Smith JL, Arteaga C, Heymsfield SB. Increased ureagenesis and impaired nitrogen use during infusion of a synthetic amino acid formula. NEJM. 1982;306:1013.
9. Delfino AH. Nutrition Education and Food Science Technology. BPC: A fish protein concentrate for human consumption. Nutrition and Food
10. Science: Present Knowledge and Utilization. Vol. 2. New York:Plenum Press;1980:249-67.
11. Bjarnason I, Macpherson A, Hollander D. Intestinal permeability: An overview. Gastroenterology. 1995;108:1566-81.
12. Wyatt J, Oberhuber G, Pangratz S, et al. Increased gastric and intestinal permeability in patients with Crohn’s disease. Am J Gastro. 1997;92(10):1891-6.
13. Best WR, Becktel JM, Singleton JW, Kern F. Development of Crohn’s disease activity index: National cooperative Crohn’s disease study. Gastroenterology. 1976;70:439-44.
14. Hanauer SB, Meyers S. Management of Crohn’s disease in adults. Am J Gastro. 1997;92(4):559-66.