TMG (Trimethylglycine) 100 caps, 750mg

Trimethylglycine is betaine, not to be confused with betaine hydrochloride, which is used to support digestion in the stomach. TMG is the supreme methylating agent and assists homocysteine in being metabolized into methionine, resulting in the production of DMG (dimethylglycine). Further metabolism of TMG produces the enzyme methyltetrahydrofolate reductase (the active form of folic acid). Studies have shown cerebrospinal fluid levels of S-adenosylmethionine (SAMe) to be low in patients with methyltetrahydrofolate reductase enzyme deficiency resulting in demyelination in the brain and degeneration of the spinal cord. TMG has been shown to restore levels of SAMe in the cerebrospinal fluid.*

Each capsule contains:
Trimethylglycine 750 mg

Suggested Use:
As a dietary supplement, 1 capsule, one to three times daily before meals, or as directed by a healthcare practitioner.

Recommended doses of betaine vary depending on the health condition being treated. The following list provides guidelines for the most common uses:

Heart disease and stroke prevention or treatment: 500 to 1,000 mg per day
Homocystinuria: 6 g per day
Autism: 500-1,500mg per day (determine dose by assessing behavioral improvements)
Hypochlorhydria: take with each meal according to product label directions

*It is generally recommended that betaine be taken in conjunction with folic acid, vitamin B6, and vitamin B12, thus a good multivitamin should cover these.

Betaine is a nutrient that plays an important role in the health of the cardiovascular system. Studies have suggested that betaine, along with other nutrients, helps to reduce potentially toxic levels of homocysteine (Hcy), a naturally occurring amino acid that can be harmful to blood vessels thereby contributing to the development of heart disease, stroke, and peripheral vascular disease (reduced blood flow to the legs and feet).

Betaine functions closely with other nutrients -- namely, S-adenosylmethionine (SAMe), folic acid, and vitamins B6 and B12 -- to break down Hcy and reduce toxic levels of this substance in the bloodstream. When betaine, or any of these related nutrients, becomes low in the body, Hcy levels may rise. Some people have a genetic condition called "homocystinuria," in which Hcy levels accumulate in the body. Betaine supplements are used to lower levels of Hcy in people with this inherited health condition.

Heart Disease and Stroke

Betaine may contribute to the lowering of Hcy, a substance recognized as a significant risk factor for atherosclerosis and blood clots in the walls of blood vessels, which can lead to a heart attack or stroke. The American Heart Association does not currently recommend population-wide Hcy screening, and suggests that obtaining appropriate amounts of betaine, as well as folic acid and vitamins B6 and B12, be met through diet alone. Individuals at high risk for developing heart disease, however, may be screened for blood levels of homocysteine. If elevated levels are detected, a healthcare practitioner may recommend supplementation in addition to dietary changes.

Liver Disease

Studies with rats have suggested that betaine may help protect against fatty deposits in the liver, which can occur from chronic alcohol use, protein malnutrition, obesity, poorly controlled diabetes, and other causes. A few studies on people have also been conducted. In one preliminary study, 10 people with fatty liver disease from causes other than alcohol received betaine for up to one year. All of the participants had improvement in liver function tests and a reduced amount of fat and other changes in the liver itself. In another larger, better-designed study that took place in Italy, nearly 200 patients received either betaine, in combination with two other substances, or a placebo. Those who received the betaine combination supplement had improved liver function, reduced fat in the liver, and diminished abdominal pain. Further research is needed to confirm these findings and to see whether it is the betaine that is specifically responsible for the benefit to the liver.

Hypochlorhydria (abnormally low levels of stomach acid)

Betaine is also used to increase the concentration of acids in the stomach. 
 
Dietary Sources
 
Dietary sources of betaine include beets, broccoli, and spinach. Interestingly, many wines contain betaine, particularly less expensive wines that use beet sugar to increase the alcohol content. Some experts suggest that this may be part of the so-called "French paradox," in which wine drinkers from France tend to have low rates of heart disease despite diets high in fat and cholesterol.