To support the activation of bone and cartilage formation
What is TRF 150? TRF 150 (Tissue Regeneration Factor) features 150 mg of Cyplexinol, a bone-derived protein/collagen complex containing Bone Morphogenetic Proteins (BMPs) and key growth factors naturally contained in bone, such as Transforming Growth Factor Beta (TGF-β), Insulin-like Growth Factor (IGF), Platelet Derived Growth Factor (PDGF), and Basic Fibroblast Growth Factor (bFGF).
Applications of TRF 150 Clinical effects of the results of supplemental BMPs are validated with multiple studies. TRF 150 is effective in helping to maintain bone strength and joint homeostasis, as well as the pathways which cause cartilage degradation because it features thoroughly researched Cyplexinol. The proteins (found in bone and bovine milk) contained in Cyplexinol have been shown to activate the bone and cartilage-forming process. TRFs Cyplexinol exerts its effect on bone via increasing bone formation and reducing bone resorption. This allows TRF 150 to address the processes which lead to cartilage degradation, as well as the ensuing pain and inflammation caused by arthritis and other degenerative joint conditions. TRF 150 should be a first line defense for any stage of osteoporosis, any type of fracture and for any condition in need of joint or cartilage repair. Consider pairing it with OsteoForce (for bones) or ArthroSoothe (for joints).
Cyplexinol studies conclude:
Cyplexinol is a bone anabolic agent (tissue regenerating)
Bone volume of rats increased by 78% given Cyplexinol
Promotes bone formation and reduces bone resorption
Improves bone mineral density even in ovariectomized rats
Improves bone mass caused by estrogen decline
Improves trabecular bone architecture, trabecular thickness, and trabecular connectivity
Important morphogens with pleiotropic functions
Mechanisms of action:
Bone and Cartilage: Osteoinductive effect (stimulating new bone formation) Bone Morphogenetic Proteins stimulate mesenchymal stem cells and differentiate them into osteoblasts (produce bone) and chondrocytes (produce cartilage).
Arthritis (rheumatoid and osteo): Anti-inflammatory effect Bone Morphogenetic Proteins have an antagonistic effect towards key pro-inflammatory cytokines (such as IL-1 and IL-6) and transcription factors all which are responsible for inflammation. BMPs have been studied for both rheumatoid and osteoarthritis (these patients are low in BMPs).
TRF 150s Cyplexinol is also involved in the maintenance and repair of articular cartilage, which covers the surface of a joint where the ends of bones meet. When this cartilage becomes damaged, the bones will grind against each other instead of having a smooth, fluid movement. Since there is no direct blood supply to cartilage, damage to these areas from injuries, misuse, or overuse leads to pain and inflammation with potentially extended recovery time. In summary, this product is ideal for healing broken bones, osteoporosis, cartilage repair, arthritis and other degenerative joint conditions.
Serving Size: 1 capsule Servings Per Container: 30
Cyplexinol containing Collagen and Bone Morphogenetic Proteins 150 mg
Recommended Dosage: As a dietary supplement, take one capsule per day, or as directed by your health care practitioner.
1) Are there any interactions with any foods to be aware of in taking this product?- No interactions with foods, can be taken with or without meals.
2) Do any of the ingredients have any hormone or estrogen content?- No
3) Are the ingredients from dairy or animal? If from animal, what animal?- no dairy, it is bovine.
Color, size or shape may appear different between lots.
STORE IN A COOL, DRY PLACE.
KEEP OUT OF REACH OF CHILDREN.
Read customer questions and answers about Osteoporosis on our blog.
TRF works in two ways: 1. Stimulates new bone formation (Osteoinductive) 2. Anti-inflammatory effect
1. Stimulating new bone formation – The Osteoinductive Effect
TRF is a bone anabolic agent (tissue regenerating), reducing bone resorption (Simic P, et al, J Biol Chem, 2006). It
is actually the bone morphogenetic proteins that are osteoinductive, as they stimulate mesenchymal stem cells and differentiate them into osteoblasts (produce bone tissue) and chondrocytes (produce cartilage). Oral supplementa- tion of TRF has been shown to have a direct effect on bone metabolism, affecting the protein collagen complex found in TRF and biomarkers such as bone collagen, bone hydroxyproline (amino acid that occurs in col- lagen and other connective tissue proteins), and bone protein synthesis (Martínez JA, et al, J. Rev Esp Fisiol. 1993).
2. Anti-inflammatory Effect (Immunoprotective)
Body/Bone morphogenetic proteins have an immunoprotective effect by exhibiting antagonist activity towards key pro-inflammatory cytokines (such as IL-1 and IL-6) and transcription factors, all of which are responsible for inflammation (Chubinskaya S, Osteoarthritis Cartilage, 2007). IL-1 activates NF-kβ transcription factor and matrix metalloproteinases (group of zinc-dependent enzymes which can break down proteins such as extracellular matrix proteins). Thus, BMPs work to suppress major inflammatory cytokines, leading to the restoration of joint and car- tilage homeostasis. In a clinical trial on Cyplexinol® PRO, its osteoinductive proteins have been reported to yield significant improvement in the reduction of joint pain and frequency of pain with an increase in activity level and joint strength in those with osteoarthritis (Garian, R, DC, CALDOP Trial, data on file).
TRF and Osteoporosis
Bone loss during aging and in post-menopausal women results from an imbalance between bone formation and resorption, which leads to an alteration in bone architecture and various degrees of bone fragility. Loss of bone strength and an increased number of bone fractures in patients with osteoporosis may be associated with a decreased capacity for bone regeneration, which is related to the lower content of BMPs and growth factors in the bone’s matrix. Since TRF is considered a bone anabolic agent, it can play an integral role in helping to decrease the progres- sion and symptoms of osteoporosis.
Research shows that BMPs improve bone mineral density even in ovariectomized rats, where ovaries have been surgically removed and bones lack BMPs. Improvements were seen in trabecular (spongy) bone architecture, trabecular thickness, and trabecular connectivity (Simic P, et al, J Biol Chem, 2006).
How to Use TRF
• TRF is available in 150 mg and 350 mg doses. Use TRF 350 when higher dosages are desired for more seri- ous bone and cartilage support.
• Can be taken with or without meals
• Consider pairing TRF with OsteoForce (for additional bone support), or ArthroSoothe (for additional joint support)