This unique supplement contains B12 in both its coenzyme forms. These forms offer unique nutritional support for MS, hepatitis, neuropathies, and Bell's Palsy. Folic acid is one of the most important and clinically valuable B vitamins. It is important to the division of cells in the body, and is essential during times of growth, such as pregnancy.  Vitamin B-12 also known as the ďanti-fatigue vitaminĒ is essential for the metabolism of nerve tissue and crucial for the health of the entire nervous system. B-12 aids in the formation of red blood cells, increases energy levels, helps iron function better, and stimulates the utilization of proteins, fats and carbohydrates. Folic acid is useful in the treatment and prevention of heart disease as it effectively lowers homocysteine levels. It aids in red blood cell production, assists in amino acid conversions, and is used in the formation of the nucleic acids for RNA and DNA. Hence, it is valuable to support wound and gut healing, cancer, cervical dysplasia, hot flashes, low sex drive in menopausal women, estrogen replacement, psoriasis, restless leg syndrome, chronic fatigue, and HIV infection.
Benefits of Vitamin B-12 include
Asthma and Allergies
Benefits of Folic Acid include
Birth defects prevention
Healthier looking skin & new skin cells
Formation and function of white blood cells
Cervical dysplasia, cervical cancer, birth control pills, fatigue, lactation, and osteoporosis
Per DFH: The NatureFolate is a concentrated vegetable powder that contains a variety of naturally occurring folates. The material is not however either standardized to nor assayed for any one specific folate. Therefore we have added or supplemented the vegetable powder with the folate, folinic acid which is one of the two primary folates found in nature. The other is 5-MTHF. This folate though, when manufactured, can occur in both the S and R forms, the S (also known as L) form being the preferred form. This is what we use in the standalone product L-5MTHF.
Each capsule contains:
Vitamin B12 (as adenosylcobalamin and methylcobalamin) 2000 mcg
Folates (NatureFolate blend) 400 mcg
Other Ingredients: Microcrystalline cellulose, magnesium stearate, dicalcium phosphate.
This product does not contain: wheat, yeast, soy, gluten, eggs, dairy, corn, artificial colors, flavors, sugars, or preservatives.
Recommended Use As a dietary supplement, take one to three capsules per day with meals or as directed by your health care practitioner.
STORE IN A COOL, DRY PLACE. KEEP OUT OF REACH OF CHILDREN.
Adenosylcobalamin and Methylcobalamin are the coenzyme forms of Vitamin B12. These are the activated forms of B12 which your body uses to perform a wide variety of functions. Designs for Health Ultra B12ĖFolate combines both coenzyme forms of B12 into one supplement to maximize the benefits of B12 in your body.*
Vitamin B12 (cobalamin) works with folic acid in many body processes including the synthesis of DNA, red blood cells, and the maintenance of the myelin sheath that surrounds nerve cells. A B12 deficiency results in pernicious anemia, impaired nerve function, and impaired mental function.
Folic acid is one of the most essential nutrients for all normal cell growth and replication. Folic acid has major role in DNA synthesis and without it cells do not divide properly. The benefit of folic acid (along with B12) supplementation is a result of reducing body concentrations of homocysteine. Homocysteine has a hand in a variety conditions, including atherosclerosis, multiple sclerosis, osteoporosis, and mental decline to name a few. Folic acid deficiency is linked to depression, atherosclerosis, and birth defects. Folic acid supplementation should always include B12 because folic acid can hide an underlying B12 deficiency, which can result in permanent nerve damage.
Conditions for B12-Folate
Impaired mental function
Low sperm counts
Multiple Sclerosis is an autoimmune demyelization disease. Myelin, the protective sheath around nerves, is destroyed and a common cause is a higher than average homocysteine level. Elevated homocysteine, as a result of folic acid and B12 deficiency, is toxic to the nervous system and has been linked to depression, schizophrenia, multiple sclerosis, Parkinsonís disease, Alzheimerís disease and cognitive decline in the elderly. People with multiple sclerosis don't metabolize B12 properly , which leaves them more vulnerable to nerve damage. Several studies have shown that vitamin B12 levels in serum, red blood cells, and CNS are low in multiple sclerosis.
Hepatitis A cobalamin deficiency impairs the immune systemís ability to fight off germs and viruses. Viral hepatitis has been treated for years with vitamin B12 as it aids the immune system in decreasing viral damage.
Neuropathies/Bellís Palsy Nerve damage created by diabetes or elevated homocysteine benefits from vitamin B12 and folate supplementation. Aggressive cobalamin therapy eases pain from nerve damage of diabetic neuropathy.  An insufficient intake of folic acid can result in numbing, tingling pain in the legs and arms.
Elevated Homocysteine Hyperhomocysteinemia is due to enzyme dysfunction, lifestyle or nutritional deficiencies. A genetic disorder causing elevated homocysteine affects only 1:200,000 births. Homocysteine is an intermediate product of methionine metabolism. If this pathway for methionine metabolism is compromised by nutrient deficiencies (vitamin B12, folic acid) homocysteine levels rise and have been implicated in cardiovascular disease, neural tube defects, spontaneous abortion, renal failure, non-insulin dependent diabetes, rheumatoid arthritis, osteoporosis, and neuropsychiatric disorders. Here is the pathway of homocysteine methylation to produce methionine: Homocysteine→Coenzyme B12→Methionine
Depression Vitamin B12 and folic acid deficiency can cause depression which is most prevalent in the elderly.  Vitamin B12 declines with age and deficiency is found in 3 to 42 percent in those 65 and over. However, anyone suffering from vitamin B12 deficiency can have symptoms of depression. Correcting an underlying vitamin B12 deficiency can result in improvement mood.
HIV/AIDS Below normal B12 levels are common in HIV disease and continue fall in most in patients. B12 may help to predict those patients whose disease will progress most rapidly.  Vitamin B12 deficiency is seen in ten to thirty-five percent of all HIV-positive patients, as a result of decreased intake, reduced absorption, or antagonism by the drug AZT. 
One of a Kind Ultra B12 Folate was created by Designs for Health as the only supplement that contains Vitamin B12 in both of its coenzyme forms. These coenzyme forms offer unique nutritional support for MS, hepatitis, neuropathies, and Bellís Palsy.
Common Questions about Ultra B12-Folate Q: I heard B12 is helpful in mercury toxicity cases. Is this true? A: Absolutely. Hereís why. Mercury depletes Vitamin B12. Many mercury toxicity symptoms are also B12 deficiency symptoms such as: numbness and tingling in the arms and legs, burning and/or red tongue, depression, fatigue, weakness, impaired mental function, and diarrhea. Pernicious anemia is the classic symptom of B12 deficiency which can be seen in chronic mercury overload. B12 is effective for getting rid of a mercury detox rash that is usually purple in color.
Q: Should I consider giving Ultra B12-Folate to elderly people? A: Yes. Several investigators have found the level of vitamin B12 declines with age and that vitamin B12 deficiency is found in 3 to 42 percent of persons aged 65 and over. If this is left untreated it can cause impaired neurological and cognitive function.
Q: I have always believed that B12 needs to be given orally or by IV. Why is Ultra B12-Folate in capsule form? A: B12 deficiency often occurs due to a lack of intrinsic factor in the gut. This is a common cause of B12 deficiency in the elderly. However, oral administration of an appropriate dosage of B12, even in the absence of intrinsic factor, results in effective elevations of B12 in the blood. An editorial entitled ďOral Cobalamin for Pernicious Anemia, Medicineís Best Kept Secret,Ē appeared in the Jan. 2, 1991, edition of JAMA. This states that oral therapy produces reliable and effective treatment, even in severe cases of pernicious anemia.  A Swedish study on 64 patients with pernicious anemia and other B12 deficiency symptoms were treated with 1000 mcgs. of oral B12 daily. In all patients studied over a 3 year period, the researchers observed complete normalization of serum levels and liver stores for Vitamin B12 as well as full clinical remission. [7,8]
Q: What doses are best to use for the mentioned conditions? A: The recommended dosage for oral B12 is 2,000 mcg daily for a minimum of 1 month. This would be just one capsule of Ultra B12-Folate daily.
References: 1. Kira J TS, and Goto I. Vitamin B12 metabolism and massive-dose methyl vitamin B12 therapy in Japanese patients with multiple sclerosis. Int Med 1994; 33:82-86. 2. Yaqub B, et al. Clinical Neurology and Neurosurgery 1992; 94:105-111. 3. Abalan F ea. Frequency of deficiencies of vitamin B12 and folic acid in patients admitted to a geriatric-psychiatry unit. Encephale 1984; 10:9-12. 4. Rule S, et al. Serum vitamin B12 and transcobalamin levels in early HIV disease. Am J Hematol 1994; 47:167. 5. Ehrenpreis E, et al. Malabsorption and deficiency of vitamin B12 in HIV-infected patients with chronic diarrhea. Dig Dis Sci 1994; 39:2159. 6. Lederly. Oral cobalamin for pernicious anemia: Medicine's best kept secret. JAMA 1991; 265:94-95. 7. Berlin H BR, and Brante G. Oral treatment of pernicious anemia with high doses of vitamin B12 without intrinisic factor. Acta Med Scand. 1968; 184:247-248. 8. Berlin R ea. Vitamin B12 body stores during oral and parenteral treatment of pernicious anemia. Acta Med Scand 1978; 204:81-84.