PLEASE NOTE: This item is currently not available.  It is being reformulated by the manufacturer. We suggest the Annatto Tocotrienols as an alternative product.  https://www.rockwellnutrition.com/product.asp?itemid=853&catid=0

This cholesterol support product is now better than ever. In addition to the tocopherol-free Annatto Tocotrienols (formerly called UltraTrienols), this formula now also includes the heavily researched polyphenol, resveratrol, along with Neptune Krill Oil. Krill oil has a unique biomolecular profile of phospholipids naturally rich in omega-3 fatty acids, EPA and DHA, and diverse antioxidants significantly different from the usual profile of fish oils.

Read Customer questions and answers about Other Health Concerns in our FAQ.

This trio of healthful nutrients is a proprietary blend, being evaluated now on 30 People in a double-blind placebo controlled study at the Hypertension Institute in Nashville, Tennessee, directed by Mark Houston MD, MSc, and funded by Designs for Health, Neptune Technologies, and American River Nutrition.The impact of this product on serum lipids (TC, LDL, HDL, TG), LDL particle number and size, lipoprotein a and other metabolic parameters will be evaluated – the first study of its kind. Results to be disclosed.

Research by Bristol Myers Squibb tells us that delta and gamma tocotrienols are the most effective at lowering cholesterol especially in the absence of tocopherols. Tocotrienols are often supplied from rice bran oil or palm oil. These contain between 30-50% tocopherols. When the tocopherols are greater than 20%, the cholesterol lowering effect is greatly reduced. [1] Annatto tocotrienols are a unique makeup of 90% delta-tocotrienol and 10% gamma-tocotrienol with zero tocopherols. Research has clearly proven the ability of tocotrienols to lower cholesterol and inhibit liver cholesterol synthesis in a manner that is similar to statins, but more gentle, and therefore not likely to cause side effects.

 How do Tocotrienols Work? They increase the conversion of farnesyl, a mevalonate derived intermediate which usually goes on to make cholesterol, instead to farnesol. This prevents farnesyl from being synthesized into squalene and then into cholesterol. The farnesol then signals the proteolytic degradation and downregulation of the HMG-CoA reductase enzyme, the same enzyme statins work on. [11] Tocotrienols also upregulate LDL receptor and LDL clearance and they inhibit the progression of carotid artery stenosis that leads to stroke. [1, 2]

Statin drugs are known to lower coenzyme Q10 production in the body which leads to side effects such as myopathy (severe muscle pain). By diverting the cholesterol synthesis pathway, annatto tocotrienols naturally increase CoQ10 synthesis which means—no side effects, better cardiac protection.

Research on Neptune Krill Oil
A study published on the effects of Neptune Krill Oil on cholesterol levels showed that krill oil supplementation in humans had positive effects on LDL levels at varying doses. Krill oil at a daily dose of 1 g, 1.5 g, 2 g, or 3 g achieved significant reductions of LDL of 32, 36, 37, and 39 percent, respectively. Baseline levels were decreased in the krill oil 1-g/day group from 168 mg/dL to 114 mg/dL, in the 1.5-g/day group from 165 mg/dL to 106 mg/dL, and in the 2- and 3-g/day groups from 183 mg/dL and 173 mg/dL to 114 mg/dL and 105 mg/dL, respectively. 2 grams of krill oil daily lowered triglycerides by 28% as compared to 3 g of fish oil daily which did not achieve a significant reduction in triglycerides. People taking only 1 g of krill oil for 90 days had a reduction in triglycerides of 12%. This increased up to 25% when they were kept on a maintenance dose of .5 g krill oil for another 90 days. People on only 1 g of krill oil lowered glucose levels by 6.3%. Because Krill Oil also naturally contains five built-in antioxidants, it is 47 times more resistant to peroxidation than fish oil and is extremely protective against free radicals.

How Does Resveratrol Work?
“Resveratrol studied from Polygonum cuspidatum (knotweed) was shown to work on acyl-coenzyme A-cholesterol acyltransferase (ACAT) activity. We now understand that it inhibits cholesterol ester formation. Among the main active chemicals of Polygonum cuspidatum, resveratrol, a kind of flavonoid, decreased ACAT activity in a dose-dependent manner. Theses results strongly suggest that flavonoids from Polygonum, mainly resveratrol, reduces the cholesterol ester formation in human hepatocytes, liver cells, by inhibiting ACAT.” [3]

Another study summarized by saying:
“Resveratrol dose-dependently suppressed both the serum triglyceride and very-low-density lipoprotein + low-density lipoprotein (VLDL + LDL)-cholesterol levels. The hypocholesterolemic action of resveratrol is attributed, at least in part, to an increased excretion of neutral sterols and bile acids into feces. These results suggest that dietary resveratrol is hypolipidemic with a tendency for anti-tumor-growth and anti-metastasis effects.” [4]

Resveratrol, a polyphenol found in red wine, is extremely anti-inflammatory which means it is also protecting the body against the other major contributor to heart disease, inflammation. Research shows that resveratrol protects against LDL oxidation (free radical damage to cholesterol caused by factors such as smoking). [5] Resveratrol also helps prevent atherosclerotic plaque formation. 10 Japanese researchers conclude: “the major polyphenols in red wine, might trap reactive oxygen species in aqueous series such as plasma and interstitial fluid of the arterial wall, thereby inhibiting oxidation of LDL and showing an antiatherosclerotic activity.” [10]

Who Should Take UltraTrienols Plus?
People wishing to avoid atherosclerotic heart disease, People with stents, People with Metabolic Syndrome, hypercholesterolemia, hyperlipidemia, and those with a family history of cancer. All People over the age of 50 will benefit from the protective effects of UltraTrienols Plus, especially smokers. For supporting healthy lipid levels, particularly cholesterol, try UltraTrienols Plus.

How to Take UltraTrienols Plus:
For best results, this product should be taken at night with dinner and away from tocopherol containing products such as Designs for Health Twice Daily Multi, DFH Complete Multi and High Gamma/Delta Vitamin E. According to a study performed by Bristol Myers Squibb, tocopherol vitamin E attenuates the effect of tocotrienols on cholesterol lowering. For best results, take 2 UltraTrienols Plus softgels every night with dinner in order to have an impact on the high diurnal synthesis of cholesterol. For an additive effect, take UltraTrienols Plus daily along with Foresterol, 1 with each meal daily.