Vitamin D 2,000 IU was brought to you by popular demand and groundbreaking research by Michale Holick, PhD, MD who has has done studies on vitamin D for the last 20 years showing that deficiency is at epidemic proportions the United States!
Are you getting 2-3 hours of direct sunlight per week with no sunscreen? Although you can obtain vitamin D from the sun, we tend not to these days since we work indoors and are scared of sun exposure. The result is that 90% of the country is vitamin D deficient.
Consequences of vitamin D deficiency include:
Generalized bone pain or isolated bone pain (Osteomalacia)
Breast, ovarian, prostate, and colon cancer
Leukemia in children
Kidney disease or kidney stones
High blood pressure
Autoimmune disease prevention (type I diabetes, MS)
Weakened liver function
Research shows that activated Vitamin D inhibits cancer cell growth, so get your 2-3 hours of sun per week, or take your vitamin D!
Serving Size 1 capsule Servings per container 120
Vitamin D3 (as Cholecalciferol) 2000 IU
Vitamin K (as Phytonadione 200 mcg
Other Ingredients: L-Leucine, microcrystalline cellulose.
Recommended Use As a dietary supplement, take one capsule per day for maintenence, or up to 50,000 IU per week for 8 weeks to correct a deficiency (less than 30 ng/ml).
STORE IN A COOL, DRY PLACE. KEEP OUT OF REACH OF CHILDREN.
WARNING: This product contains vitamin K. Consult your health care practitioner before use if you are taking Aspirin, Coumadin, Warfarin or antibiotics.
This product does not contain wheat, yeast, soy protein, gluten, eggs, dairy, corn, artificial colors, flavors, sugars, or preservatives.
After an impressive two hour presentation by Dr. Michael Holick, PhD, MD from a Harvard and a teacher at Boston University Medical Center, I finally understood the that Vitamin D deficiency is an epidemic in our country. It is a huge contributor and cause to osteoporosis, bone pain (osteomalacia), and hormone related cancers. According to his nationwide research, it is impossible to get enough vitamin D from our diets. And 90% of people in the US are deficient! (even those who think they get enough sun every week). If you live in a cold climate any part of the year, you need to take your vitamin D.
Vitamin D is a serious deficiency and rarely diagnosed by doctors in routine screening. He recommends we all get a blood test (25(OH)D Assay, not the 1,25(OH)2). Also, we ALL need to take a minimum of 1,000 IU of vitamin D per day (or min 30 minutes of direct sunshine with no sunscreen 3-4x week- and four times more for those with dark or black skin). If you are deficient, you should take at least 5,000 IUs per day for several months. Vit D levels are considered deficient unless they are over 30ng/ml, and ideally should be above 70. His research showed that by increasing vitamin D levels he was able to increase bone density by 23% in 2 years! No medication does anything close to this. I recommend you read Dr. Michael Holick’s book The UV Advantage.
Why is vitamin D deficiency on the rise? Many people are avoiding sun exposure due to fear of ozone layer problems, or because of skin cancer or concern of skin wrinkling. Twenty minutes of sun exposure daily to 6% exposed skin is necessary for maintaining our body’s own production of vitamin D.
Risk factors for deficiency also include drugs which bind fats such as Cholestyramine, a bile acid sequestering medication, and laxatives. Intake of Olestra and soluble fiber can also potentially reduce vitamin D absorption from food. Statin drugs can cause cholesterol levels to fall lower than ideal which may contribute to vitamin D deficiency. Patients with fat malabsorption, problems with bile production or production of lipase for digesting fats are also susceptible to low vitamin D levels. For these individuals consider LV-GB (liver-gallbladder support formula) and/or Digestzymes (digestive support formula containing Lipase enzyme).
Research shows that African Americans and Latinos with darker skin pigmentation or a dark tan have a much higher incidence of vitamin D deficiency, especially in northern states. They may require up to four times longer sun exposure to absorb the same amount of UVB as light or untanned skin, because melanin blocks UVB.
Obese individuals are also at higher risk since they can have 50% lower plasma levels of vit D than normal weight people, for the same supplementation levels or sun exposure.
Women with low hormone levels are more susceptible to vitamin D deficiency. Estrogen or progesterone deficiency (amenorrhea, surgical or age-onset menopause) impairs the formation of the active form of vit D.
Aging skin has a reduced capacity of vitamin D synthesis. By age 75, vitamin D levels can be 25% lower than levels in younger individuals.
Vitamin D Benefits: SKELETAL SYSTEM Plays a role in:
strength of bone and cartilage
teeth and gum health
Deficiency may lead to:
osteoporosis, osteomalacia, osteoarthritis, muscle weakness and pains, periodontal disease
secondary hyperparathyroidism 
GLUCOSE METABOLISM 
role in insulin production
improves glucose tolerance
certain types of hypertension
CRP, fibrinogen, IL-6 
IMMUNE SYSTEM [2, 4] May reduce:
inflammation, such as caused by neuronal injury 
deficiency may cause fatigue and fibromyalgia like symptoms
May counteract some detrimental effects of corticosteroids, such as osteoporosis and susceptibility to infections [8, 13]
The current RDA for vitamin D is set at 200-600IUs for 20 -75 year olds respectively. This level of supplementation seems inadequate in the light of recent research, the increase in immune problems, and the shockingly high number of patients showing up deficient in blood tests today. Vitamin D contributes in multiple ways to the optimal function of the human body because virtually every cell has a receptor for it including the islet beta cells of the pancreas which is where vitamin D has its impact on aiding the production of insulin.  Vitamin D3 (cholecalciferol) is synthesized in the skin from cholesterol in response to absorbing UVB rays. It gets converted in the liver to 25 hydroxycholecalciferol, known as 25 (OH)D3. In the kidneys it meets up with an important enzyme, 1-alpha-hydroxylase and finally gets converted into its active hormonal form 1,25 dihydroxycholecalciferol, known as 1,25 (OH)2D3, which goes straight to the heart of every cell, the nucleus, and influences its physiology to take the healthy pathways by dictating genetic expression.
The Body’s Control of Vitamin D Synthesis Hepatic synthesis of 25 (OH)D3 is only loosely regulated, and blood levels of this molecule largely reflect the amount of vitamin D produced in the skin or ingested. In contrast, the activity of 1-alpha-hydroxylase in the kidney is tightly regulated and serves as the major control point in production of the active hormone. Parathyroid hormone is the major inducer of 1-alpha-hydroxylase. Low blood phosphate levels induce it as well. This means that 25 (OH)D3 is the best marker for vitamin D status because it best reflects vitamin D stores and is telling us how much the skin is making and how much we are consuming.
It is Very Important to Supplement Vitamin D With Vitamin K In a study on postmenopausal women given a vitamin D supplement with minerals, these subjects showed a worsening of the elasticity of the arteries. In the other group given vitamin D with K and minerals, artery elasticity remained stable.  This is due to their interaction in the use of MGP, Matrix Gla Protein, which is a strong inhibitor of arterial calcification. The expression of MGP is D dependent and the gamma-carboxylation step, making it active, is K dependent. Another study out of Wake Forest University, says “hyperlipidemia, vitamin D, nicotine, and warfarin, alone or in various combinations, produce arterial calcification in animal models. MGP has recently been discovered to be an inhibitor of bone morphogenetic protein-2, the principal osteogenic growth factor. Many of the forces that induce arterial calcification may act by disrupting the essential post-translational modification of MGP, allowing BMP-2 to induce mineralization. MGP requires gamma-carboxylation before it is functional, and this process uses vitamin K as an essential cofactor. Vitamin K deficiency, drugs that act as vitamin K antagonists, and oxidant stress are forces that could prevent the formation of Gla residues on MGP.” 
So, don’t think of just vitamin D for the bones, vitamin K is also necessary for directing the transport of calcium into bone and teeth for optimal strength.  Increasing the amount of calcium in the blood stream by proper supplementation with calcium and vitamin D in the presence of inadequate levels of vitamin K, can increase the risk of calcium deposition in arteries and soft tissue. Vitamin K can be obtained from vegetables, supplements and can also be synthesized by intestinal friendly bacteria. DFH Osteoforce provides calcium, magnesium, vitamin D and vitamin K along with all the necessary cofactors for proper bone metabolism. PaleoGreens is also a great source of vitamin K due to the many vegetables it contains. Vitamin D and vitamin A compete for absorption and excessive vitamin A levels can antagonize some of the beneficial effects of vitamin D, and this may be why high intakes of vitamin A (20,000 IUs) were shown to increase the risk of bone fractures.
Many People are Susceptible to Vitamin D Deficiency Deficiency of vitamin D has been linked to exacerbation of many conditions. Vitamin D supplementation may be needed to support optimal physiological function. Deciding how much vitamin D to supplement should be based on the degree of deficiency as seen by blood test results. Vitamin D is fat soluble and excessive levels can be toxic, so blood levels need to be followed up regularly. Supplementation above 1000 IU’s should continue until patient reaches optimal reference range. See Table 1.  Most reference ranges for commercial labs are around [9- 54]ng/mL, but so-called normal range for 25(OH)D3 was probably defined in early studies by assessing a population of subjects with inadequate vitamin D nutrition or sunlight exposure.  Most doctors are aiming for 100 ng/mL as optimal. Vitamin D toxicity symptoms: nausea, headaches, constipation, kidney stones, mental confusion, heart arrhythmia. Do not supplement additional vitamin D in cases of hyperparathyroidism, sarcoidosis or patients on Coumadin or Warfarin.
A high percentage of modern humans have suboptimal levels of vitamin D body stores because UVB exposure is too low at latitudes above 40 degrees, such as all northern American states, especially during cold seasons and due to the: smog/ozone layer, spending time indoors, clothing and sunblock usage.  Some drugs bind fats, including fat soluble vitamin D and contribute to low vitamin D levels. These drugs include cholestyramine, a bile acid sequestering medication, and laxatives. Intake of Olestra and soluble fiber can also potentially reduce vitamin D absorption from food. Statin drugs can cause cholesterol levels to fall lower than ideal which may contribute to vitamin D deficiency. Patients with fat malabsorption and problems with bile production or production of lipase for digesting fats are also susceptible to low vitamin D levels. For these individuals consider LV-GB Complex (liver-gallbladder support formula) and/or Digestzymes (digestive support formula containing the lipase enzyme). Patients with dark skin pigmentation or a dark tan may require up to four times longer sun exposure to absorb the same amount of UVB as light or untanned skin, because melanin blocks UVB. African decent individuals have a much higher incidence of vitamin D deficiency, especially in northern states. Obese individuals can have 50% lower plasma levels of vitamin D than normal weight people, for the same supplementation levels or sun exposure.  Women with low hormone levels are more susceptible to vitamin D deficiency. Estrogen or progesterone deficiency (amenorrhea, surgical or age-onset menopause) impairs the formation of the active form of vitamin D.  This is especially critical because the risk of autoimmune diseases increases with aging and vitamin D would be protective.  Aging skin has a reduced capacity of vitamin D synthesis. By age 75 levels can be 25% lower than younger individuals.
Vitamin D Protects from Autoimmune Disease Vitamin D acts as a controller that reduces excessive proliferation of the immune cells (TH1 type) that are responsible for attacking our own body cells (such as nerve/brain cells in the case of Multiple Sclerosis, joint structures in case of arthritis, pancreatic cells in the case of Diabetes Type I).12 The effect of vitamin D supplementation can be noticed almost immediately, although body stores take time to get to optimal levels. One study noted that the down regulation of the autoimmune attack was dramatically reduced within 24-48 hrs, following the ingestion of a high dose of vitamin D. “Altogether, vitamin D immunomodulatory potency is comparable to other established immunosuppressants without sharing their typical adverse effects.”  One important advantage of using vitamin D for calming auto immune disease is that it does not impair the resistance to infections and does not cause osteoporosis, like corticosteroids or other immune suppressants do.  Adequate calcium intake was also shown to be important in realizing some of the immunological effects of vitamin D. DFH Calcium Malate Chelate, found in Twice Daily Essential Packets, contains vitamin D and should be considered along with Designs for Health's new Vitamin D 2000 IU. For osteoporosis consider Vitamin D 2000 IU along with OsteoForce bone formula.
Vitamin D Mechanisms of Reducing Cancer Risk and Survival  Vitamin D induces cell differentiation and apoptosis of cancer cells, reduces excessive cell proliferation and increases natural killer cell activity. Resveratrol, from red wine, was shown to sensitize breast cancer cells to the apoptotic action of vitamin D. Resveratrol can be found in DFH FemGuard + Balance, Grape Seed Supreme and Ultimate Antioxidant HS.
Vitamin D and Insulin Sensitivity According to a study performed at UCLA, published in the American Journal of Clinical Nutrition May 2004, there is a positive correlation between vitamin D levels and insulin sensitivity. In other words, subjects with normal glucose tolerance tests with low vitamin D levels, showed poor insulin sensitivity based on beta cell function and were much more likely to have at least two other components of metabolic syndrome. 
Vitamin D Tech Sheet References: 1. Mathieu C,Gysemans C Vitamin D and diabetes. Diabetologia. 2005 Jun 22 . 2. Nagpal S, Na S Non-Calcemic Actions of Vitamin D Receptor Ligands. Endocr Rev. 2005 Mar 29; 3. Calvo MS, Whiting SJ Vitamin D intake: a global perspective of current status. J Nutr. 2005 Feb;135(2):310-6. 4. Holick MF.Sunlight and vitamin D for bone health and prevention of autoimmune diseases, cancers, and cardiovascular disease. Am J Clin Nutr. 2004 Dec;80(6 Suppl):1678S-88S. 5. Horl WH.The clinical consequences of secondary hyperparathyroidism: focus on clinical outcomes. Nephrol Dial Transplant. 2004 Aug;19 Suppl 5:V2-8. 6. Wallin R, Wajih N.Arterial calcification: a review of mechanisms, animal models, and the prospects for therapy. Med Res Rev. 2001 Jul;21(4):274-301 7. Vieth R. Vitamin D supplementation, 25-hydroxyvitamin D concentrations, and safety. Am J Clin Nutr. 1999 May;69(5):842-56. 8. Huff GR, Huff WE .The effect of vitamin D3 on resistance to stress-related infection in an experimental model of turkey osteomyelitis complex. Poult Sci. 2000 May;79(5):672-9. 9. Mosekilde L. Vitamin D and the elderly. Clin Endocrinol (Oxf). 2005 Mar;62(3):265-81. 10. Holick MF. Decreased bioavailability of vitamin D in obesity. Am J Clin Nutr. 2000 Sep;72(3):690-3. 11. Vieth R.Why the optimal requirement for Vitamin D3 is probably much higher than what is officially recommended for adults. J Steroid Biochem Mol Biol. 2004 May;89-90(1-5):575-9. 12. Hayes CE, Nashold FEThe immunological functions of the vitamin D endocrine system. Cell Mol Biol (Noisy-le-grand). 2003 Mar;49(2):277-300. 13. May E, Asadullah K . Immunoregulation through 1,25-dihydroxyvitamin D3 and its analogs. Curr Drug Targets Inflamm Allergy. 2004 Dec;3(4):377-93. 14. Malcok UA, Sengul G .Therapeutic effect of vitamin D3 in a rat diffuse axonal injury model. J Int Med Res. 2005 Jan-Feb;33(1):90-5. 15. McCarty MF. Secondary hyperparathyroidism promotes the acute phase response -- a rationale for supplemental vitamin D in prevention of vascular events in the elderly. Med Hypotheses. 2005;64(5):1022-6. 16. Iwamoto J, Yeh JK, Comparative effects of vitamin K and vitamin D supplementation on prevention of osteopenia in calcium-deficient young rats. Bone. 2003 Oct;33(4):557-66 17. Wallin R, Wajih N.Arterial calcification: a review of mechanisms, animal models, and the prospects for therapy. Med Res Rev. 2001 Jul;21(4):274-301 18. Caniggia A, Lore F, Main endocrine modulators of vitamin D hydroxylases in human pathophysiology. J Steroid Biochem. 1987;27(4-6):815-24. 19. Grant WB, Holick MF. Benefits and requirements of vitamin D for optimal health: a review. Altern Med Rev. 2005 Jun;10(2):94-111. 20. Hanley DA, Davison KS.Vitamin D insufficiency in North America. J Nutr. 2005 Feb;135(2):332-7. 21. Braam LA, Hoeks AP, et al. Beneficial effects of vitamins D and K on the elastic properties of the vessel wall in postmenopausal women: a follow-up study. Thromb Haemost. 2004 Feb;91(2):373-80. 22. Wallin R, Wajih N.Arterial calcification: a review of mechanisms, animal models, and the prospects for therapy. Med Res Rev. 2001 Jul;21(4):274-301 23. Chiu KC, Chu A, Hypovitaminosis D is associated with insulin resistance and beta cell dysfunction. Am J Clin Nutr. 2004 May;79(5):820-5.
The DFH Synergy caps are a great source of Vitamin D, with 2000 IU per tiny capsule. My vitamin D scores tested low, and this makes it easy to take the 2000-4000 IU per day my doctor recommended.
Reviewed by Professor E from St. Louis, MO.
The evidence is mounting that vit D is essential to our health in many ways, including cancer fighting. I trust Designs for Health and Rockwell so I take this as the recommended brand. I'll let you know in 40 years if it has been a good cancer fighter. ;)
Vitamin D Synergy caps
Reviewed by Amstanford from FL.
I like this brand because it is one of the few available without soy. I am allergic to soy and it is near impossible to find supplements (or much else for that matter) without it.
The price is fair, the service is excellent and the shipping is free.
Great Vitamin D Supplementation!
Reviewed by sunnyinla from Los Angles.
I've been taking Designs for Health Vitamin D for a few months and seen increasing levels of my Vitamin D. I take 2 capsules daily for a total of 4,000 IU. I am pleased with how product has worked out well for me and would recommend it to anyone looking for Vitamin D supplementation.
Vitamin D Synergy caps (2000 IU) by Designs For Health
Reviewed by WindyCity from Chicago, IL.
Another cold and flu season is upon us. I am keeping safe with an extra dose of Vitamin D.
Since I became a customer of Rockwell Nutrition, I have never looked back. Their customer rewards program is top notch.
Vitamin D Synergy
Reviewed by F. M. from OH.
Great way to get your Vitamin D levels up to par!
Vitamin D Synergy caps 2000IU
Reviewed by Marlene from San Pedro, CA.
My Vitamin D test results went up using this product. Noticed that I haven't had a cold since my Vit. D level became normal. I take it everyday.
Vitamin D capsules
Reviewed by kATHY from youngstown ny.
i feel that designs for health is a good product
carefull with the ingredients also that it has Vitamin K in it for better health
Reviewed by Sarah from Southbury, CT.
I switched from a health food store brand to this and my numbers went up! This says it all.
Easy to take
Reviewed by JackieM from Vail, CO.
An easy to take capsule. I made it through the flu season without getting sick this year since I have been taking this product. Maybe what "they" say about it boosting your immune system is true.
Reviewed by LINDA from FLORIDA.
THIS VITAMIN IS A GODSEND AS IT LIFTS MY MOODS.
Reviewed by Jessica from Milwaukee.
I was looking for a decent vitamin D supplement and this one worked for me.
Reviewed by Nikki from MI.
My naturalist always recommends DFH products, and the Vitamin D did not disappoint. Its high potency, quality product and fair price make it a great deal.
Reviewed by Ann from Winston-Salem, NC.
This product helped to get my Vitamin D levels to where they should be, and that is very important for women now.
Reviewed by michelle from olney, md.
Great product, a great way to get the Vitamin D that you need, especially in the winter months when the sun is not abundant. Arrived in a timely manner.
Reviewed by Michelle from Glen Allen, VA.
I love this product. As a doctor, I know how important supplementation with Vitamin D is and this is what I take now
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