Our highest potency vitamin D product, providing 10,000 IU of vitamin D per serving.Vitamin D Ultra 10K contains a higher therapeutic dose than our Vitamin D Supreme (5,000 IU/serving), and is intended for situations where more aggressive vitamin D repletion is required.
Our lower dosage option, Vitamin D Synergy (2,000 IU/serving), should be considered for maintaining optimal blood levels of vitamin D for long-term supplementation in patients exposed to adequate sunlight.
Vitamin D Ultra 10K also includes vitamin K in both K1 and the MK-7 form of K2, which is highly bioavailable. Both of these forms of vitamin K are important to our health: Vitamin K1 (the naturally occurring form of vitamin K in vegetables) and Vitamin K2 as MK-7, which is a product of soy fermentation (free of soy allergens) and has the special property of metabolizing slowly throughout the day. Vitamins D and K are essential for optimal bone and arterial health and for maintaining the immune system in proper balance.
Vitamins D and K ? an important synergistic relationship We now know how important vitamin K is for directing the transport of calcium into bone and teeth for optimal strength. Increasing the amount of vitamin D, via supplementation, in the presence of inadequate levels of vitamin K, can increase the risk of calcium deposition in arteries and soft tissue and have a negative effect on artery elasticity. This is due to the interaction of both vitamin K and vitamin D with matrix Gla protein (MGP), which is a strong inhibitor of arterial calcification. The expression of MGP is vitamin D dependent and the gamma-carboxylation step, making it active, is vitamin K dependent. Together, D and K make a great team.
CAUTION: Vitamin K may adversely interact with anticoagulation drugs known as blood thinners. Patients taking these medications should be medically supervised while taking Vitamin D Ultra 10K.
Serving Size: 1 capsule Servings Per Container: 60
Active Ingredients:
Vitamin D3 (as Cholecalciferol) 10000 IU
Vitamin K (as Vitamin K1 Phytonadione 200 mcg; Vitamin K2 Menaquinone-7 20 mcg) 220 mcg
Recommended Dosage: As a dietary supplement, take one capsule per day or as directed by your health care practitioner.
This product does not contain: This product does not contain wheat, yeast, gluten, eggs, dairy, corn, artificial colors, flavors, sugars, or preservatives.
Consult your health care provider before taking this product if you are taking Coumadin, warfarin or other anticoagulant medications.
Color, size or shape may appear different between lots.
STORE IN A COOL, DRY PLACE. KEEP OUT OF REACH OF CHILDREN.
Read customer questions and answers about Vitamin Deficiency on our blog.
References
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Noncalcemic actions of vitamin D receptor ligands. Nagpal S, Na S, Rathnachalam R. Endocr Rev. 2005 Aug;26(5):662-87. Epub 2005 Mar 29. Review.
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Sunlight and vitamin D for bone health and prevention of autoimmune diseases, cancers, and cardiovascular disease. Holick MF. Am J Clin Nutr. 2004 Dec;80(6 Suppl):1678S-88S. Review.
The clinical consequences of secondary hyperparathyroidism: focus on clinical outcomes. Hrl WH. Nephrol Dial Transplant. 2004 Aug;19 Suppl 5:V2-8. Review.
Arterial calcification: a review of mechanisms, animal models, and the prospects for therapy. Wallin R, Wajih N, Greenwood GT, Sane DC. Med Res Rev. 2001 Jul;21(4):274-301. Review.
Vitamin D supplementation, 25-hydroxyvitamin D concentrations, and safety. Vieth R. Am J Clin Nutr. 1999 May;69(5):842-56. Review.
The effect of vitamin D3 on resistance to stress-related infection in an experimental model of turkey osteomyelitis complex. Huff GR, Huff WE, Balog JM, Rath NC. Poult Sci. 2000 May;79(5):672-9.
Vitamin D and the elderly. Mosekilde L. Clin Endocrinol (Oxf). 2005 Mar;62(3):265-81. Review.
Decreased bioavailability of vitamin D in obesity. Wortsman J, Matsuoka LY, Chen TC, Lu Z, Holick MF. Am J Clin Nutr. 2000 Sep;72(3):690-3. Erratum in: Am J Clin Nutr. 2003 May;77(5):1342.
Why the optimal requirement for Vitamin D3 is probably much higher than what is officially recommended for adults. Vieth R. J Steroid Biochem Mol Biol. 2004 May;89-90(1-5):575-9. Review.
The immunological functions of the vitamin D endocrine system. Hayes CE, Nashold FE, Spach KM, Pedersen LB. Cell Mol Biol (Noisy-le-grand). 2003 Mar;49(2):277-300. Review.
Immunoregulation through 1,25-dihydroxyvitamin D3 and its analogs. May E, Asadullah K, Zgel U. Curr Drug Targets Inflamm Allergy. 2004 Dec;3(4):377-93. Review.
Therapeutic effect of vitamin D3 in a rat diffuse axonal injury model. Malcok UA, Sengul G, Kadioglu HH, Aydin IH. J Int Med Res. 2005 Jan-Feb;33(1):90-5.
Secondary hyperparathyroidism promotes the acute phase response -- a rationale for supplemental vitamin D in prevention of vascular events in the elderly. McCarty MF. Med Hypotheses. 2005;64(5):1022-6.
Comparative effects of vitamin K and vitamin D supplementation on prevention of osteopenia in calcium-deficient young rats. Iwamoto J, Yeh JK, Takeda T, Ichimura S, Sato Y. Bone. 2003 Oct;33(4):557-66. Erratum in: Bone. 2004 Mar;34(3):589-90.
Main endocrine modulators of vitamin D hydroxylases in human pathophysiology. Caniggia A, Lor F, di Cairano G, Nuti R. J Steroid Biochem. 1987;27(4-6):815-24. Review.
Benefits and requirements of vitamin D for optimal health: a review. Grant WB, Holick MF. Altern Med Rev. 2005 Jun;10(2):94-111. Review.
Vitamin D insufficiency in North America. Hanley DA, Davison KS. J Nutr. 2005 Feb;135(2):332-7. Review.
Beneficial effects of vitamins D and K on the elastic properties of the vessel wall in postmenopausal women: a follow-up study. Braam LA, Hoeks AP, Brouns F, Hamuly k K, Gerichhausen MJ, Vermeer C. Thromb Haemost. 2004 Feb;91(2):373-80.
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