B-Complex Plus by Pure Encapsulations

As a complex, the B vitamins are essential for the proper functioning of the nervous system and are perhaps the most important nutritional factor for healthy nerve cells. The B vitamins also play a role in the conversion of carbohydrates into energy, in the metabolism of fats and protein, and in the maintenance of muscle tone in the GI tract. The B vitamins support the integrity of the skin, hair, and liver. This balanced combination of functionally interrelated B vitamins provides wide ranging benefits, yet is specifically supportive of the nervous system.

As part of a well-balanced diet that is low in saturated fat and cholesterol, folic acid, vitamin B6, and vitamin B12 may reduce the risk of vascular disease.

Biotin

Folate

Folate (5-MTHF or 5-methyltetrahydrofolate)

Inositol

Vitamin B-1 (thiamine)

Vitamin B-12 (cobalamin)

Vitamin B-12 (methylcobalamin)

Vitamin B-2 (riboflavin)

Vitamin B-3 (inositol hexanicotinate or niacin)

Vitamin B-3 (niacin)

Vitamin B-3 (niacinamide or niacin)

Vitamin B-5 (pantothenic acid or calcium pantothenate)

Vitamin B-6 (pyridoxal 5' phosphate)

Vitamin B-6 (pyroxidine)

Vitamin C

Vitamin C (ascorbyl palmitate)

Activation of folic acid and interconversion of reduced folate metabolites.

DHF, dihydrofolate; DHFR, dihydrofolate reductase; THF, tetrahydrofolate reductase; MTHFR, methyltetrahydrofolate reductase; 5-MTHF, methyltetrahydrofolate; SAMe, S-adenosylmethionine; SAH, S-adenosylhomocysteine; dUMP; deoxyuridine monophosphate; dTMP, deoxythymidine monophosphate.

An extensive body of evidence indicates that adequate folate intake may provide significant cardiovascular, cellular and neural protection. However, genetic variations affecting activation and metabolism of supplemental folic acid are highly prevalent. In line with our commitment to consistently offer innovative, science-based ingredients, Pure Encapsulations has updated a number of products†, including our multivitamins, to provide Metafolin® (L-5-MTHF). Metafolin® is a naturally occurring, universally metabolized and active form of folate, L-5-MTHF. As such, it can be directly used in a diverse array of essential methylation reactions to support cardiovascular, neural and emotional health. Additionally, clinical evidence indicates that the bioavailability of Metafolin® is superior to folic acid. In a double-blind, randomized, placebocontrolled intervention study of 144 women of child-bearing age, 5-MTHF supplementation resulted in a greater accumulation of 5-MTHF in red blood cells than equimolar doses of folic acid.