Pain X Plus 60 count by Biogenesis Nutraceuticals

Pain X Plus

Nutritional and Herbal Support for the reduction of Acute Pain

• Provides 240 mg of salicin
• Phytosomal turmeric increases bioavailability and utilization of turmeric
• Caffeine anhydrous enhances the overall action for acute pain modulation

Supplement Facts
Serving Size :2 Capsules
Servings Per Container 30

White willow bark extract (Salix alba)(25% salicin) 960mg
Meriva (proprietary blend of turmeric rhizome extract
and phosphatidylcholine from soy) 250 mg
Caffeine anhydrous 130 mg

Other Ingredients: Gelatin, rice flour, silica, titanium dioxide, sodium copper chlorophyllin.

Contains soy and natural salicylates.

Avoid if allergic to salicylates.

Keep tightly capped and store in a cool, dry place. If pregnant or
breastfeeding, consult your healthcare professional before use.
KEEP OUT OF REACH OF CHILDREN. Do not use
if either tamper-evident seal is broken or missing.

PAIN X PLUS is a targeted formulation with ingredients to help modulate acute
pain. This formulation provides a unique combination of bioavailable ingredients
at levels that have been shown to be clinically effective. Pain X Plus is a convenient
and helpful way to support a reduction in acute pain and discomfort.

WHITE WILLOW BARK (SALIX ALBA) is traditionally used to treat pain. The efficacy
of this botanical is due mainly to the proportion of salicin present. White willow
bark is present in this formulation at a 25% standardized extract; a dose of two
capsules will provide 240 mg of salicin. This is the amount shown in the research
to be effective at reducing low back pain. The salicin, a precursor to salicylic acid,
works as an antipyretic, anti-inflammatory and as an analgesic.

MERIVA (proprietary blend of turmeric rhizome extract and phosphatidylcholine
from soy) is a phytosomal form of turmeric, where it is bonded to
phosphatidylcholine in order to increase its absorption and bioavailability.
Research shows that when turmeric is bonded to phosphatidylcholine, it improves
the levels of curcuminoids in the blood and the liver at least 20-fold. Studies
show that turmeric modulates leukotriene synthesis, platelet aggregation, and
neutrophil inflammatory response. In addition, it promotes a reduction in the
activation of NF Kappa B and promotes fibrinolysis. Turmeric may potentiate
endogenous corticosteroids, thus having indirect anti-inflammatory actions as well.

CAFFEINE ANHYDROUS has been shown in studies to have a statistically
significant benefit in promoting pain reduction when combined with other
pain-relieving ingredients, irrespective of the pain condition or the type of
analgesic. This effect was shown when the caffeine amount used was greater
than 100 mg, as it is in this formulation.

1. Chrubasik S et al. Treatment of low back pain with a herbal or synthetic anti-rheumatic: a randomized
controlled study. Willow bark extract for low back pain.Rheumatology. 2001 Dec;40(12):1388-93.
2. Cuomo, J et al. Comparative Absorption of a
Standardized Curcuminoid Mixture and Its Lecithin Formulation. J Nat Prod. 2011.
3. Derry CJ, Derry S, Moore RA. Caffeine as an analgesic adjuvant for acute pain in adults. Cochrane Database Syst Rev. 2012 Mar 14;3.
4. Marczylo TH, et al. Comparison of systemic availability of curcumin with that of curcumin
formulated with phosphatidylcholine. Cancer Chemother Pharmacol. 2007 Jul;60(2):171-7. Epub
2006 Oct 19.
5. Srimal RC, Dhawan BN. Pharmacology of diferuloyl methane (curcumin),
a non-steroidal anti-inflammatory agent. J Pharm Phamarc. 1973 Jun;25(6)447-52.