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Biotone EFA by Genestra

100 caps
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Biotone EFA

Rationale & Viability of revised Biotone EFA Formulation

Biotone EFA has many therapeutic indications as supported by various forms of research as noted below. Seroyal is continuously researching each ingredient in each one of our formulations against the most recent scientific evidence. As we propose these findings to our expert committee we believe it is sometimes necessary after laborious analysis of the research and our client?s expectations, to optimize our formulations to remain as a leader in the natural pharmaceutical industry.

Changes on the Biotone EFA label:

  • The phytosterol amount has been increased from 16 mg/capsule to 112 mg/capsule based on recent evidence of the benefits of phytosterols on cardiovascular health and cholesterol reduction.
  • Along with octacosanol, we have added hexacosanol, tetracosanol, triacontanol and dotriacontanol. All of these components are included under policosanol, which has been found to have positive effects on cardiovascular health and cholesterol reduction.

Cardiovascular disease (CVD), including stroke, coronary occlusion, ischemic heart disease (IHD), atherosclerosis heart disease, vascular and coronary thrombosis, is the leading cause of death in most western societies. The factors most consistently associated with an increase in the incidence of CVD include hypertension, hypercholesterolemia, and cigarette smoking. Other modifiable risk factors include obesity, lack of exercise, hypertriglyceridemia and low high-density lipoprotein-cholesterol (HDL-C) levels (Patch et al, 2006).

The clinical manifestations of CVD are chronic arterial obstructions or acute arterial occlusions in various territories, which ultimately lead to the condition where there is an inadequate supply of blood to the heart muscle, brain or visceral limbs leading to ischemia in severe cases, myocardial infarction (Patch et al, 2006).

High blood cholesterol level (especially LDL cholesterol) is a risk factor for coronary heart disease (CHD). Oxidation of excess LDL cholesterol leads to arterial wall plaque build up, which then restricts blood flow and increased risk of coronary heart disease and stroke.

Biotone EFA is a unique combination of rice bran, soybean and wheat germ oils specifically formulated to support and regulate hormonal function. Rice bran and wheat germ oils are high in octacosanol, fatty acids, phytosterols, and in ketosteroids, anabolic growth agents, and lipotropic factors. Octacosanol, found in wheat and in rice oil fractions, improves heart functions, increases vitality and endurance, prevents muscle spasms, and duplicates the biological effects of sex hormones and ketosteroids without the side-effects associated with hormone therapy.

How are Essential Fatty Acids (EFAs) broken down in the body? Does
it require much work from the liver? 

EFAs are broken down in the gut (hydrolyzed) and the individual fatty acids are absorbed by the enterocytes lining the GI tract. The enterocytes assemble the fatty acids and glycerol into triglycerides.The triglycerides and other fat soluble nutrients are collected and assembled into chylomicrons, which are absorbed by the lacteals (lymphatic vessels of the small intestines). The chylomicrons flow with the lymph into the blood and reaches every tissue in the body. In the tissues the triglycerides are absorbed in a similar way as triglycerides are absorbed by the enterocytes. In the tissues the fatty acids can be metabolized into for example local hormones.

The hydrolization process in the gut requires lipase secreted by the pancreas and bile synthesized in the liver and secreted from the gallbladder.

Supplement Facts
Serving Size 2 Capsules
Servings per Container 50

Two Capsules Contain

Calories 5
Vitamin E (d-alpha-tocopherol /mixed tocopherol concentrate) 2.5 IU
Safflower (Carthamus tinctorius) seed oil 510 mg
Flaxseed (Linum usitatissinum) oil ▲ 72 mg
Alpha-Linolenic Acid 36 mg
▲Total Linoleic Acid 348 mg
Free Plant Sterols (from Glycine max bean)
(95% combined: beta-sitoserol, campesterol, stigmasterol) 224 mg
Soy Lecithin (from Glycine max bean) 40 mg
Policosanol (from Apis mellifera wax) 5 mg
Mixed Tocopherol Concentrate 8 mg
Gamma-Tocopherol 3.4 mg
Delta-Tocopherol 1440 mcg

Other ingredients: Bovine gelatin, glycerin, purified water, yellow beeswax
Contains: Soy

Recommended Adult Dose: Take two capsules two times daily or as recommended by your healthcare practitioner.

Guaranteed to contain no added wheat, starch, yeast, gluten, corn, sodium, sugar, artificial coloring or flavoring, antimicrobial preservatives or dairy products.

Safety-sealed for your protection and for product freshness. Do not use if outer seal is missing or broken. Store in a cool, dry place.

If you are pregnant or breastfeeding; if you currently have or previously had breast cancer and/or breast tumors or if you have a predisposition to breast cancer, as indicated by an abnormal mammogram and/or biopsy, or a family member with breast cancer, do not use. Ensure you are up-to-date on mammograms and gynecological evaluations prior to use. If you are taking blood thinners or hormone replacement therapy, including thyroid hormone replacement therapy; if you have a history of hormonal or gynecological disease, including ovarian cancer, endometriosis and/or uterine fibroids, consult your healthcare practitioner prior to use. If you experience breast pain, discomfort and/or tenderness or a recurrence of menstruation and/or uterine spotting, discontinue use and consult your healthcare practitioner. If you have a liver disorder, develop liver related symptoms or if symptoms worsen, consult your healthcare practitioner.

Warning: This product has come into contact with soy. Do not use this product if you have a soy allergy.

Biotone EFA is indicated for hormonal imbalances, including premenstrual and menopausal disorders; and for maintaining skin elasticity, energy levels and a strong immune system during periods of stress. Biotone EFA can be taken as an organic alternative to steroids for those athletes and individuals who want to increase performance, lean muscle mass and strength, without the side-effects associated with synthetic steroids.

None known.

Available as
100 Capsules    400

Research & Scientific Rationale
Plant sterols are plant compounds with similar chemical structure and biological functions as cholesterol. It has been reported that phytosterols esters reduce cholesterol absorption and lower serum cholesterol concentration; sterols are an essential component of cell membranes, and both animals and plants produce them. Sterols are saturate (they have no double bonds in the sterols ring) and are produced by hydrogenating sterols.

The FDA authorized the use of labelling health claims for foods containing plant sterol esters, including beta-sitosterol, for reducing the risk of coronary heart disease (FDA, 2000). This rule is based on the FDA's conclusion that plant sterol esters may reduce the risk of coronary heart disease by lowering blood cholesterol levels. Phytosterols appear to inhibit the absorption of dietary cholesterol and the reabsorption (via the enterohepatic circulation) of endogenous cholesterol from the gastrointestinal tract. Consequently, the excretion of cholesterol in the feces leads to decreased serum levels of this sterol

A recent review concluded that plant sterols and stanols; reduce the risk of heart disease by one quarter (Law 2000). This is the reduction expected from the decrease in serum cholesterol. A randomized, double-blind, 3-group parallel, controlled study evaluated the influence of esterified plant sterols on serum lipid concentrations in adults with mild-to-moderate primary hypercholesterolemia (Maki et al. 2001). Results indicated that when combined with a standard cholesterol-lowering diet, use of a spread enhanced with phytosterols improved total cholesterol, LDL cholesterol, HDL cholesterol, and triglycerides as compared to a normal reduced-fat spread. In a separate RCT, margarine enriched with sterol-esters from soybean oil reduced plasma total- and LDL-cholesterol concentrations by 8-13% when compared to control (Weststrate and Meijer 1998).

Another possible effect of plant sterols is their antioxidant activity. It was found that the methanol extract of soybean oil, which has a strong in-vitro protective effect against DNA damage in human endothelial cell, contains phytosterols in addition to tocopherols, Thus based on results from in vitro studies and on human study, there is a possibility that plant sterols may possess antioxidant properties. Such as antioxidant protection could also benefit atherosclerosis (Berger et al, 2004). A recent paper explored the antioxidant properties of plant sterols (campesterol, B-sitosterol, stigmasterol) and reported that phytosterols themselves can act as an antioxidant in-vitro, a modest radical scavenger in solution, and physically as a stabiliser in liposomal membranes (SCF, 2002).

Policosanol has been reported to decrease total cholesterol and low density lipoprotein (LDL) cholesterol in male and female patients with elevated cholesterol. Outcomes of over 60 clinical trials have been reviewed in detail, and reports of cholesterol lowering are very consistent (Hargrove et al, 2003). Reports suggest that the plasma concentration of high-density lipoprotein cholesterol cholesterol (HDL) increases at a slower rate than LDL decreases, so that the LDL:HDL ratio significantly improves within 1 year (Hargrove et al, 2003).

On the basis of the primary efficacy variable (ie, the change in LDL-C), treatment with Policosanol was effective. This study shows that Policosanol (5mg/d) administered for 8 weeks was effective in decreasing LDL-C in patients with borderline to mildly elevated serum TC values (Castano et al.,2003).

True waxes are defined chemically as esters formed between long chain fatty acids and long chain alcohols. The human diet has always contained modest levels of waxes. Beeswax or honeycomb is the richest natural dietary source of long chain aliphatic alcohols (Hargrove et al, 2003).

Preclinical studies have demonstrated that Policosanol administered orally for 4 weeks to normocholesterolaemia rats, partially prevented in vitro and in vivo microsomal lipid peroxidation and inhibited lipid peroxidation of lipoprotein fractions containing LDL-C + VLDL-C (Menendez et al, 2000). In another Clinical trial was found that policosanol administered at doses (5 and 10 mg day) within its conventional dosage as a lipid-lowering drug decreased the susceptibility of LDL-C to metal ion-dependent and macropague-mediated lipid peroxidation (Menendez etal, 2000).

Researchers have studied the lipid lowering effects of policosanol in a wide variety of subjects including healthy volunteers and patients with hypercholesterolemia have shown policosanol to have lipid lowering effect (Herman, 2004).


  1. Berger A, Jones P, Abumweis S. Plant sterols: factors affecting their efficacy and safety as functional food ingredients. Lipids in Health and Disease 2004: 3(5).
  2. Castano G, Tula L, Canetti M, et al. Effects of policosanol in hypertensive patients with type II hypercholesterolemia. Curr Ther Res 1996;57:691-5.
  3. Food and Drug Administration (FDA) . Food Labelling: health claims; Plant Sterol/Stanol Esteres and Coronary Heart Disease. 2000.
  4. Hargrove J, Greenspan P, Hartle D. Nutritional Significance and Metabolism of Very Long Chain Fatty Alcohols and Acids from Dietary Waxes. University of GeORGIA 2003;215-226.
  5. Herman D. Policosanol: A non-prescription Dietary Supplement to Control Hyperlipidemias. 2004. Volume 15 Issue 2.
  6. Law M. Plant sterol and stanols margarines and health. British Medical Journal 2000;320;861-864.
  7. Menendez R. Mas R, Amor A, Gonzalez R, Fernandez J, Rodeiro I, Zayas M, Jimenez S. Effects of Policosanol treatment on the susceptibility of low density lipoprotein (LDL) isolated from healthy volunteers to oxidative modification in vitro. Journal Clinical Pharmacology 2000;50;255-262.
  8. Patch C, Tapsell L, Williams P, Gordn M. Plant sterols as dietary adjuvants in the reduction of cardiovascular risk: theory and evidence. Vascular Health and Risk Management 2006:2(2) 157-162.
  9. Scientific Committee on Food (SCF). General view of the scientific committee on food on the long-term effects of the intake of elevated levels of phytosterols from multiple dietary sources, with particular attention to the effects of B-Carotene. Commission E. Brussel, Belgium 2002

Additional References

  1. Hormones / Menopause
    Policosanol prevents bone loss in ovariectomized rats.
    Noa M, M?s R, Mendoza S, G?mez R, Mendoza N, Gonz?lez J.
    The purpose of this study was to determine whether policosanol could prevent bone loss in the bones of ovariectomized rats by comparing its effects with those induced by estradiol (sex hormone). In conclusion, policosanol prevented bone loss and decreased bone resorption in ovariectomized rats, suggesting that it should be potentially useful in preventing bone loss in postmenopausal women.
    Drugs Exp Clin Res. 2004;30(3):117-23.
  2. Effects of soy protein and isoflavones on circulating hormone concentrations in pre- and post-menopausal women: a systematic review and meta-analysis.
    Hooper L, Ryder JJ, Kurzer MS, Lampe JW, Messina MJ, Phipps WR, Cassidy
    Isoflavone-rich soy products decrease follicle-stimulating hormone (FSH) and luteinizing hormone (LH) in premenopausal women and may increase estradiol (sex hormone) in post-menopausal women. The clinical implications of these modest hormonal changes remain to be determined.
    Hum Reprod Update. 2009 Mar 19. [Epub ahead of print]
  3. Impact of soy supplementation on sex steroids and vascular inflammation markers in postmenopausal women using tibolone: role of equol production capability.
    T?rm?l? R, Appt S, Clarkson TB, Mueck AO, Seeger H, Mikkola TS, Ylikorkala O.
    Soy modified the concentrations of estrone, testosterone and some endothelial markers. Soy supplementation may be clinically significant in tibolone (synthetic hormone-type drug).
    Climacteric. 2008 Oct;11(5):409-15.
  4. New equol supplement for relieving menopausal symptoms: randomized, placebo-controlled trial of Japanese women.
    Ishiwata N, Melby MK, Mizuno S, Watanabe S.
    Equol, a metabolite of the isoflavone daidzein, is hypothesized to play a major role in the health benefits of soy. S-equol supplement improved mood-related symptoms in perimenopausal/postmenopausal equol nonproducers.
    Menopause. 2009 Jan-Feb;16(1):141-8.
  5. Effects of soy protein isolate and moderate exercise on bone turnover and bone mineral density in postmenopausal women.
    Evans EM, Racette SB, Van Pelt RE, Peterson LR, Villareal DT.
    In postmenopausal women soy protein isolate reduces bone turnover with no impact on bone mineral density over 9 months.
    Menopause. 2007 May-Jun;14(3 Pt 1):481-8.
  6. Androstenedione production by biotransformation of phytosterols.
    Malaviya A, Gomes J.
    Androstenedione is a key intermediate of microbial steroid metabolism. It belongs to the 17-keto steroid family and is used as starting material for the preparation of different steroids. Androstenedione can be produced by microbial side chain cleavage of phytosterol, which is an alternative to multi-step chemical synthesis.
    Bioresour Technol. 2008 Oct;99(15):6725-37. Epub 2008 Mar 10. Review.
  7. Endurance / Athletes
    Octacosanol supplementation increases running endurance time and improves biochemical parameters after exhaustion in trained rats.
    Kim H, Park S, Han DS, Park T.
    exercise-trained control group (EC) rats ran 184% longer until exhaustion than sedentary control group rats, while octacosanol-supplemented trained rats ran 46% longer than EC rats.
    J Med Food. 2003 Winter;6(4):345-51.

UPC 8.83E+11
Manufacturer: Genestra
SKU: 10400

Customer Reviews
Average Rating on 23 Reviews
(05 stars in 23 rating(s))
1 star rating Delivery 3/3/2014 Biotone EFA by Genestra1
Reviewed by LT from Spokane.
The product came by way of UPS and required a signature in order for them to leave it. I will not order from this company again because of that.

5 star rating Biotone 7/6/2013 Biotone EFA by Genestra5
Reviewed by Teton from Colorado.
Biotone was recommended by an acupuncture doctor to help me relieve stress and sleep better. It worked! And when I order from Rockwell it's easy and I receive my supplements fast. Thanks so much!

3 star rating Biotone EFA Helped Sleep at First 11/11/2012 Biotone EFA by Genestra3
Reviewed by JC from San Diego, CA.
I have been taking Biotone EFA now for several months. The first few months it was a godsend, as my sleep improved dramatically. However, after awhile it seemed to stop working.

5 star rating Biotone EFA 10/14/2012 Biotone EFA by Genestra5
Reviewed by gumby from Colorado.
great product - very effective and highly recommended by my naturopath. good price and good service from Rockwell Nutrition.

5 star rating Great results 11/14/2011 Biotone EFA by Genestra5
Reviewed by david butters from Daytona Florida.
I was recommended this product by my accupuncturist for a natural help with gaining lean muscle boosting energy. It really works and I dont train without it.

4 star rating Biotone efa 5/22/2011 Biotone EFA by Genestra4
Reviewed by Jo-Jo from Port Orchard,wa.
To soon to tell the effects of this product but it was highly recommended by my naturopath.

5 star rating Biotone EFA's 4/30/2011 Biotone EFA by Genestra5
Reviewed by Virginia from Tillamook, Oregon.
Using Biotone EFA's has helped normalize my thyroid function. A few months ago I had my cholesterol tested and my numbers were great! Rockwell Nutriton prices are much better than buying them in the doctor's office, too.

5 star rating Good night, brain 2/25/2011 Biotone EFA by Genestra5
Reviewed by Akia Tanara from Colorado.
This product was recommended by my Chiropractor to help me sleep after late Board meetings when my brain wouldn't shut off. It's a great relief to sleep soundly, whenever I need the help.

5 star rating Biotone EFA by Genestra 8/24/2010 Biotone EFA by Genestra5
Reviewed by Lauren Hubele from Austin.
I began using this product for hotflashes that were making me crazy-especially at night. Within days my symptoms had improved AND best of all I was sleeping again!

3 star rating Good product, packaging issue 7/23/2010 Biotone EFA by Genestra3
Reviewed by ESM from Arlington, VA.
Recommended by my naturopath for Hashimoto's thyroid support as part of a larger protocol. The whole protocol is working, but I'm not sure how much each individual element is contributing to the overall improvement. This was the best price that I found for this product. One bad thing was that when these supplements arrived, the box was quite warm and many of the pills were stuck together. I was under the impression that a cold pack would be used for shipping, but one was not used.

4 star rating super producr 7/23/2010 Biotone EFA by Genestra4
Reviewed by mary from ballston spa. ny.
Using Biotone with my regular workout has helped with my toning goals.

5 star rating Sleeper Hit! 7/20/2010 Biotone EFA by Genestra5
Reviewed by Rios from San Francisco, CA.
Recommended by my Naturopath for sleep regulation, I've not had insomnia since taking Genestra Biotone. It's also a big help to be able to purchase it at such an inexpensive price!

5 star rating Biotone regulates sleep 7/19/2010 Biotone EFA by Genestra5
Reviewed by Diana from South China, Maine.
I have had numerous difficulties with my metabolism, including menopause that seems to drag on forever and resulting difficulties with sleep. Biotone helps my body to get sleepy rather than surge with energy when it's time to sleep. I would recommend giving it a try if you struggle with sleep.

5 star rating Improved nails and hair 7/19/2010 Biotone EFA by Genestra5
Reviewed by Aleksandra from Kent,WA.
This product was first recommended by a naturopath. Having taken biotone for about 2 months I've noticed an improvement in the quality of my hair and nails. The price is also far cheaper than what I used to pay at the doctor's office.

5 star rating Great! 5/5/2010 Biotone EFA by Genestra5
Reviewed by Elizabeth from Arlington, VA.
This price was better than at my naturopath's office and the best price I found.

5 star rating Biotone EFA by Genestra 3/2/2010 Biotone EFA by Genestra5
Reviewed by Rena from Sarasota/Florida.
Rockwell has the best price on this product. My holistic vet prescribed this product for my dogs as they are allergic to marine products...one capsule a day . They are doing very well with it.

5 star rating Best Price for a Great Product 2/11/2010 Biotone EFA by Genestra5
Reviewed by beth from Temecula, CA.
I shopped around and I could not believe the price. It was the best price I found for a great product! Thanks!

5 star rating Wouldn't be without it 11/25/2009 Biotone EFA by Genestra5
Reviewed by Bonnie from Sedro Woolley, WA.
Great product for vegetarians who do not eat fish products and have food allergies. It was highly recommended by my naturopath.

5 star rating Excellent product 11/25/2008 Biotone EFA by Genestra5
Reviewed by Julia from South Dakota.
My naturopath recommened this and I would not go without it. My sleep patterns have improved and just feel better with this in my routine.

5 star rating must have 10/8/2008 Biotone EFA by Genestra5
Reviewed by Sally from Washington, DC.
Has become an essential part of my nightly routine. A noticeable difference in my sleep patterns.

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