CuraPro 750mg 60gels by Euromedica

CuraPro 60 gels

CuraPro® is a powerful antioxidant that provides support for a healthy inflammation response and
cellular signaling pathways.* This single ingredient supplement features BCM-95® curcumin, making it
the ideal choice for protocols based on curcumin research.

BCM-95® curcumin:

Curcumin is a compound from turmeric, a spice used traditionally as a food ingredient and as a botanical
in Ayurvedic medicine.

Benefits associated with curcumin include:

• Immune system modulation
• Protection from oxidative stress, and support for the body’s natural inflammatory response.

However, although curcumin has shown great promise for many benefits, it is not easily absorbed.

Clinical trials have used increasingly larger dosages (up to 10-12 grams daily) in order to get even a small
amount into the bloodstream. Efforts to make curcumin more bioavailable have included combinations
with lecithin, a lipid generally sourced from soy, and/or piperine, a compound from black pepper.

Adding lecithin is one option that can increase absorption, and published rat studies have indicated that
this may boost absorption five-fold over plain curcumin. There have not yet been human absorption
studies published on this delivery method. Piperine presents potential issues with drug interactions
because of its influence on the metabolism of drugs in the liver. It is contraindicated for concomitant use
with most prescription medications, including anti-seizure, cardiac, blood pressure and cancer drugs.

A patent-protected method using micronized curcumin, turmeric essential oil, and phospholipids ensures that CuraPro delivers a curcumin that is up to 10 times better absorbed than standard curcumin, as well as having an 8-12 hour retention time in the body. It has up to 6.3 times more absorption than curcumin complexed with lecithin and piperine. This high-potency formula provides superior support for a healthy inflammation response, a healthy immune and cardiovascular system, and resistance to free radical activity.

Enhanced oral bioavailability of curcumin in the blood up to 7 to 10 times that of curcumin 95%, based on published human trials

A patented 100% natural turmeric extract (3 U.S. Patents awarded)

Proprietary blend of curcuminoids and essential oil of turmeric

Full spectrum of natural curcuminoids

Extended retention of curcumin in the blood up to 8 to 12 hours

Proven to support joint, immune, and brain function 1-16

High ORAC value >13,000 per gram

Click here to learn more:

WHY BCM-95® CURCUMIN?

BCM-95® BROCHURE

Amount per 1 softgel:

• Proprietary Complex 750 mg
  --- Curcumin CRX 791 (BCM-95®) Micronized (Curcuma longa) Rhizome Extract, phospholipids, turmeric essential oils

Other Ingredients: medium chain triglycerides, gelatin, glycerin, high phosphatidylcholine lecithin (soy), purified water, yellow beeswax

Recommendations: 1-2 softgels daily, or as directed by your health care professional. This proprietary complex provides enhanced bioavailability and sustained retention time in the body.

Contains no sugar, salt, yeast, wheat, gluten, corn, dairy, artificial coloring, artificial flavoring, or preservatives. Contains only natural ingredients. Color variations are normal.

If pregnant or nursing, consult a health care professional before use.

Questions about dosing: Should CuraPro & CuraPhen be taken after a meal? Or is there a better time to take these & can they be used together for additional support?

Answer from EuroMedica: We recommend that most supplements be taken with meals or food as most people have better absorption this way and it eliminates any risk of upset stomach for those who have sensitivities.

However, I have heard of people taking these at all times and with and without food with excellent results. Yes Curaphen and CuraPro can be used together for additional support.

CuraPro is a very high dose of just one ingredient, our clinically proven BCM-95 curcumin. Curaphen is our professional pain formula. It contains a much smaller dose of BCM-95 curcumin and 3 other products that work together to address pain issues.

BCM-95 has been proven to have a blood retention time of 8-12 hours. With that said, I would dose a morning and an evening dose of Curaphen for those who are really struggling with pain control. Or Morning, noon, and night.

This chart shows the difference in absorption between the BCM-95® and curcumin complexed with piperine or lecithin.

Liver Support & Detoxification:

Curcumin appears to support healthy liver cell development. Research has shown that concentrated curcumin can protect the mitochondrial surface within the cells, and promote the body’s own ability to support healthy cellular division.* 13-15 While combining curcumin with piperine can help increase absorption, it can also interact with cytochrome P450 in the liver and interacts with most prescription medications. That’s why it’s important to find a curcumin exactly like BCM-95, which does not use piperine to increase absorption.

Conclusion:

1. Antony B, Merina B, Iyer VS, Judy N, Lennertz K, Joyal S. A pilot cross-over study to evaluate human oral
   bioavailability of BCM-95 CG (Biocurcumax™) a novel bioenhanced preparation of curcumin. Ind J Pharm
   Sci. 2008:445-449.
2. Benny B, Antony B. Bioavailability of Biocurcumax (BCM-95). Spice India. Sept;2006:11-15.
3. Jurenka JS. Anti-inflammatory properties of curcumin, a major constituent of Curcuma longa: a review of
   preclinical and clinical research. Altern Med Rev. 2009;14(2):141-53.
4. Jacob A, Wu R, Zhou M, Wang P. Mechanism of the Anti-inflammatory Effect of Curcumin: PPAR-gamma
   Activation. PPAR Res. 2007;89369.
5. Biswas S, Rahman I. Modulation of steroid activity in chronic inflammation: a novel anti-inflammatory role
   for curcumin. Mol Nutr Food Res. 2008;52(9):987-94.
6. Kulkarni SK, Dhir A. An overview of curcumin in neurological disorders. Indian J Pharm Sci. 2010;72(2):149-
   54.
7. Hatcher H, Planalp R, Cho J, et al. Curcumin: from ancient medicine to current clinical trials. Cell Mol Life
   Sci 2008;65:1631-1652.)
8. Johnson SM, Gulhati P, Arrieta I, et al. Curcumin inhibits proliferation of colorectal carcinoma by
   modulating Akt/mTOR signaling. Anticancer Res. 2009;29(8):3185-90.
9. Ravindran J, Prasad S, Aggarwal BB. Curcumin and cancer cells: how many ways can curry kill tumor cells
   selectively? AAPS J. 2009;11(3):495-510.
10. Dhillon N, Aggarwal BB, Newman RA, et al. Phase II trial of curcumin in patients with advanced pancreatic
    cancer. Clin Cancer Res 2008;14:4491-4499
11. Kidd PM. Bioavailability and activity of phytosome complexes from botanical polyphenols: the silymarin,
    curcumin, green tea, and grape seed extracts. Altern Med Rev. 2009;14(3):226-46.
12. Aggarwal BB, Kumar A, Bharti AC. Anticancer potential of curcumin: preclinical and clinical studies.
    Anticancer Res. 2003;23(1A):363-98.
13. Seehofer D, Schirmeier A, Bengmark S, et al. Curcumin Attenuates Oxidative Stress and Inflammatory
    Response in the Early Phase after Partial Hepatectomy with Simultaneous Intraabdominal Infection in
    Rats. J Surg Res. 2008 Dec 31.
14. Wang M, Ruan Y, Chen Q, Li S, Wang Q, Cai J. Curcumin induced HepG2 cell apoptosis-associated
    mitochondrial membrane potential and intracellular free Ca(2+) concentration. Eur J Pharmacol. 2010 Sep
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15. Volak LP, Ghirmai S, Cashman JR, Court MH. Curcuminoids inhibit multiple human cytochromes P450,
    UDP-glucuronosyltransferase, and sulfotransferase enzymes, whereas piperine is a relatively selective
    CYP3A4 inhibitor. Drug Metab Dispos. 2008;36(8):1594-605.
16. Kulkarni S, Dhir A, Akula KK. Potentials of curcumin as an antidepressant. Scientific World Journal.
    2009;9:1233-41.
17. Li YC, Wang FM, Pan Y, Qiang LQ, Cheng G, Zhang WY, Kong LD. Antidepressant-like effects of curcumin on
    serotonergic receptor-coupled AC-cAMP pathway in chronic unpredictable mild stress of rats. Prog
    Neuropsychopharmacol Biol Psychiatry. 2009;33(3):435-49.
18. Lima CF, Pereira-Wilson C, Rattan SI. Curcumin induces heme oxygenase-1 in normal human skin
    fibroblasts through redox signaling: Relevance for anti-aging intervention. Mol Nutr Food Res. 2010 Oct
    11. [Epub ahead of print]
19. Garcea G, Berry DP, Jones DJ, et al. Consumption of the putative chemopreventive agent curcumin by
    cancer patients: assessment of curcumin levels in the colorectum and their pharmacodynamic
    consequences. Cancer Epidemiol Biomarkers Prev. 2005;14:120-125.
20. Wang R, Li YB, Li YH, Xu Y, Wu HL, Li XJ. Curcumin protects against glutamate excitotoxicity in rat cerebral
    cortical neurons by increasing brain-derived neurotrophic factor level and activating TrkB. Brain Res.
    2008;1210:84-91.
21. Sikora E, Bielack-Zmijewska A, Mosieniak G, Piwocka K. The promise of slow down ageing may come from
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22. Zhang C, Browne A, Child D, Tanzi RE. Curcumin decreases amyloid-beta peptide levels by attenuating the
    maturation of amyloid-beta precursor protein. J Biol Chem. 2010;285(37):28472-80.