Gluco-Flex Forte, provided by Douglas Laboratories, is a synergistic blend of glucosamine sulfate, n-acetyl glucosamine and bovine cartilage. The combination of these products has been carefully formulated and specifically designed to help maintain the structure and function of healthy joints.
INDICATIONS Gluco-Flex Forte may be a useful nutritional adjunct for individuals who wish to support the body’s connective tissues, such as skin, tendons, ligaments, bone, and cartilage.
SUGGESTED USE Adults take 1 capsule daily with meals or as directed by physician.
SIDE EFFECTS No adverse side effects reported.
STORAGE Store in a cool, dry place, away from direct light. Keep out of reach of children.
FUNCTIONS Glucosamine is a naturally occurring amino sugar found in glycosoaminoglycans (mucopolysaccharides), integral components of the proteoglycans found in joint cartilage. Proteoglycans are large carbohydrate rich structures that provide resiliency, load distribution, shock-absorbing, compressive and lubricating properties to joints and connective tissues. Dietary glucosamine serves as an immediate precursor for glycosaminoglycan synthesis, and also stimulates incorporation of other precursors into the connective tissue matrix. The availability of glucosamine is an integral part of the synthesis of glycosaminoglycans and proteoglycans that are necessary during the constant remodeling that aging cartilage undergoes. Thus, the maintenance of healthy aging cartilage may be improved with enhanced deposition of glycosaminoglycans and proteoglycans. Bioavailability of oral glucosamine sulfate is excellent. It is absorbed intact, and utilized very quickly by all tissues, including connective tissues. Both n-acetyl glucosamine and glucosamine sulfate have shown in studies to be effective sources of glucosamine for glycosaminoglycan and proteoglycan synthesis in all connective tissues, such as cartilage, ligaments, tendons, skin, and bone. Chondroitin, a component of bovine cartilage, a glycosaminoglycan formed in the body, is also used for the synthesis and maintenance of connective tissue, primarily within the cartilage matrix. In addition, chondroitin protects existing cartilage by reducing water loss from the matrix and by inhibiting the enzymatic breakdown of the cartilage. The overlapping activities as well as functional differences of glucosamine and chondroitin offer several advantages for combined supplementation. Although glucosamine is a precursor for chondroitin synthesis, this process requires large amounts of metabolic energy. Dietary preformed chondroitin spares the use of glucosamine for this purpose. Instead, glucosamine can be used for formation of other important glycosaminoglycans and proteoglycans. When adequate chondroitin is thus available to help protect tissues from premature breakdown, glucosamine can more readily stimulate synthesis of healthy new tissue.
REFERENCES Böhmer D, Ambrus P, Szögy A, and Haralambie G. Treatment of chondropathia patellae in young athletes with glucosamine sulfate. In: Current Topics Sports Medicine (Bachl N et al., eds.) Urban & Schwarzenberg, Vienna, 1984, p.799. Crolle G, and D’Este E. Glucosamine sulfate for the management of arthrosis: a controlled clinical investigation. Curr. Res. Med. Opin. 1980; 7:104. D’Ambrosio E, Casa B, Bompani R, Scali G, and Scali R. Glucosamine sulfate: a controlled clinical investigation in arthrosis. Pharmatherapeutica 1981; 2:504. Drovanti A, Bignamini AA, and Rovati AL. Therapeutic activity of oral glucosamine sulfate in osteoarthritis: a placebo-controlled double-blind investigation. Clin. Ther. 1980; 3:260. Engel M, Maurel P, Margolis RK .Chondroitin sulfate proteoglycans in the developing central nervous system. I. Cellular sites of synthesis of neurocan and phosphacan. J Comparative Neurology 1996;366:34-43. Lopes Vaz A. Double-blind clinical evaluation of the relative efficacy of ibuprofin and glucosamine sulfate in the management of osteoarthrosis of the knee in outpatients. Curr. Res. Med. Opin.1982; 8:145 McCarty MF. Glucosamine for wound healing. Medical Hypothesis 1996;47:273-275. Morreale P, et al. Comparison of the antiinflammatory efficacy of chondroitin sulfate and diclofenac sodium in patients with knee osteoarthritis. J Rheumatol 1996;23:1385-91. Piptone VR. Chondroprotection with chondroitin sulfate. Drugs Exp Clin Res 1991;17 (1):3-7. Pujalte JM, et al. Double-blind clinical evaluation of oral glucosamine sulfate in the basic treatment of osteoarthrosis. Curr Med Res Opin 1980;7:110-114. Tapadinhas MJ, Rivera IC, Bignamini AA. Oral glucosamine sulfate in the management of arthrosis: report on a multi-centre open investigation in Portugal.1982;3(3):157-168.
Manufacturer: Douglas Labs
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