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Annatto Tocotrienols with Black Cumin Seed Oil by Designs For Health (DFH)

60 softgels
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Annatto Tocotrienols with Black Cumin Seed Oil

Annatto Tocotrienols is a unique tocopherol-free, tocotrienols-only product, containing 125mg tocotrienols along with 1g black cumin seed oil (Nigella sativa) per two softgel serving. The synergistic combination of tocotrienols and black cumin makes it most efficacious for supporting a healthy inflammatory response, healthy lipid levels, and for defending against oxidative stress.

The tocotrienols are extracted from the South American annatto bean and contain 90% delta-tocotrienol and 10% gamma-tocotrienol. For best results, this product should not be taken within six hours of taking a vitamin E supplement containing d-alpha tocopherol.

Annatto Tocotrienols with black cumin seed oil may help support*:
  • Cardiovascular health/lipid management
  • Neuroprotective properties
  • Antioxidant protection
  • Immune function
  • A healthy inflammatory response
  • Anti-proliferative properties

Supplement Facts

Serving Size 2 softgels
Servings Per Container 30

Amount Per Serving

Black Cumin Seed Oil (Nigella sativa)(seed) 1 g
Tocotrienols (delta, gamma) 125 mg

Other Ingredients: Medium chain triglycerides; bovine gelatin, glycerine, purified water, annatto (natural color) (softgel ingredients).

Recommended Use: As a dietary supplement, take two softgels per day, or as directed by your health care practitioner.

Does not contain gluten. Notice: Color, size or shape may appear different between lots.


*All raw materials have been reviewed and validated by DFH QC to be non-GMO (based on supplier documentation)

Annatto Tocotrienols is a unique tocopherols-free, tocotrienols-only product, containing 125 mg tocotrienols along with 1g black cumin seed oil (Nigella sativa) per two softgel serving. Like tocopherols, tocotrienols (T3) have four isomers: alpha, beta, gamma and delta. Reserach indicates that the two most potent forms of tocotrienols are delta and gamma T3. This product contains 90% delta and 10% gamma-T3, a makeup unique to annatto and not found in rice bran and palm oils (two of the other richest sources of tocotrienols). Combined tocotrienol and tocopherol concentrates from these oils, referred to as “tocotrienol-rich fractions,” usually contain 30-50% tocopherols; however, the most effective concentrates for reducing oxidative indicators and supporting cardiovascular health in human studies are those with low tocopherols and high tocotrienols. In fact, tocopherols may actively interfere with the beneficial cardiovascular and anti-proliferative properties of tocotrienols.1-4

Annatto Tocotrienols are tocopherol-free because they are extracted from food grade annatto. Annatto is the most commonly used carotenoid in foods, added to provide a naturally derived orange-yellow color.

Cardiovascular Health

Cardiovascular health is an area where tocotrienol-rich preparations have been shown to be more effective than tocopherols. Tocotrienols are potent lipophilic antioxidants and have demonstrated hypocholesterolemic effects, believed to result from reduced oxidation of unsaturated lipids in cell membranes and lipoprotein particles. Tocotrienols may reduce foam cell formation by reducing oxidation of LDL particles and reducing the surface expression of cellular adhesion molecules. Tocotrienols may also have a favorable influence on blood lipids by reducing the translation of HMG-CoA reductase mRNA as well as increasing the degradation of the enzyme post-transcriptionally (this enzyme is the rate-limiting step in the cholesterol synthesis pathway).5 Delta-T3 has been shown to be the most effective tocotrienol fraction in regard to reducing the expression of adhesion molecules involved in atherogenesis in the endothelium.5 Tocotrienols may also aid in the management of hypertension. Animal models have demonstrated improved endothelial nitric oxide synthase (eNOS) activity and reduced systolic blood pressure upon supplementation with gamma-T3.5

Neuroprotective Benefits

Tocotrienols have been shown to protect neurons through mechanisms involving not only their antioxidant properties, but also through activation of protective signaling molecules. Animal studies demonstrate that tocotrienols are more effective than tocopherols at protecting neurons from glutamate-induced cell death.6,7 With mitochondrial dysfunction and oxidative damage increasingly believed to be involved in the pathogenesis of Alzheimer’s disease and other forms of neurodegeneration, antioxidant tocotrienols may be beneficial additions to existing therapies. In fact, patients with Alzheimer’s disease and mild cognitive impairment typically have significantly lower plasma levels of tocotrienols and tocopherols.8-10

Antiproliferative Factors

Tocotrienols’ role in cancer has been demonstrated through multiple mechanisms: enhanced apoptosis, cell cycle arrest, reduced angiogenesis and inhibition of proliferation (both due to reduction in vascular endothelial growth factor and reduced blood supply), enhanced immune function (increased expression of interferon-gamma, IgA and IgG), reduced risk of initial cancer occurrence (possibly resulting from the antioxidant protection of DNA), and reduced inflammation (decrease in NF?B, IL-1, IL-6, TNF-a, COX-2, 12-LOX). The potential effects of tocotrienols with cancer have been demonstrated in models of breast, prostate, colon, liver, pancreatic, lung, skin and stomach cancer, suggesting they target activity not limited to specific types of tissue.11-21

Black Cumin Seed Oil – synergy with tocotrienols

The seeds of Nigella sativa, commonly known as black cumin, have been used in Western Asia for thousands of years as a spice, food preservative, and traditional remedy with efficacy across a wide range of health conditions, including hypertension, digestive disorders, pain, diarrhea, and skin disorders.22 One of black cumin seed oil’s primary active compounds—thymoquinone (TQ)—has shown antioxidant and anti-inflammatory properties, as well as anti-cancer and immuno-modulatory effects (via augmenting T-cell and natural killer cell activity), all of which may act synergistically with tocotrienols. This powerful compound is also a demonstrated hepato- and renal-protective agent.23 In addition to TQ, black cumin seed oil contains carvacrol, a compound also found in oregano and thyme, which has anti-inflammatory, anti-tumor and analgesic properties.24,25

Animal models of chemically induced liver and kidney damage support the hepato- and nephro-protective effects of TQ. Furthermore, in animals experiencing ischemia/reperfusion, TQ normalizes levels of glutathione and lactate dehydrogenase.26 Other studies support the role of TQ in enhancing the activity of related antioxidant enzymes, including catalase, glutathione peroxidase, glutathione S-transferase and superoxide dismutase.27

TQ may also be a useful adjunct for autoimmune, allergic and inflammatory conditions. Compared to placebo, supplementation with black cumin seed oil resulted in significant improvement in disease activity in patients with rheumatoid arthritis.28 The combination of TQ’s anti-inflammatory effects with its role as an antihistamine offers a two-pronged mechanism to help alleviate symptoms of several respiratory disorders, including bronchial asthma and allergic rhinitis.26 Isolated TQ and whole black cumin seed oil act as inhibitors of COX and 5-LOX, two inflammatory mediators. Animal models have shown the intact oil to have a greater effect on the reduction of inflammatory eicosanoids and reduced lipid peroxidation than TQ alone, suggesting a synergistic effect for compounds in the whole oil aside from isolated TQ.27

Animal models of multiple sclerosis and ulcerative colitis point to TQ as a potential therapeutic aid, likely due to its modulation of T-cell activity, amelioration of oxidative stress and anti-inflammatory activity.27 The role of TQ in facilitating sufficient levels of antioxidant-replenishing enzymes may be why black cumin seed oil exhibits efficacy across such a wide range of health concerns. TQ exhibits several functions that support its impressive potential as an anti-cancer agent, and these properties may be even more powerful when combined with tocotrienols, attacking carcinogenesis and proliferation on multiple fronts. Unlike many conventional chemotherapy drugs, TQ has been shown in animal models to be anti-proliferative against certain cancers (breast, lung, colorectal, pancreatic, prostate, and glioma/glioblastoma), while having only a limited influence on healthy cells.27

TQ has shown anti-cancer properties via cell cycle arrest, reduced angiogenesis and metastasis, and activation of genes that regulate apoptosis.27 Researchers believe black cumin seed oil’s role in inhibiting 5-LOX may be partly responsible for the reduced proliferation and enhanced apoptosis demonstrated in several types of cancer.29
Combining conventional chemotherapy drugs with TQ seems to enhance the efficacy of the conventional treatments, suggesting that black cumin seed oil may be a novel adjunct to more traditional cancer therapies. TQ has been shown to augment the cytotoxic effects of cisplatin, gemcitabine, paclitaxel, and doxorubicin.27

In addition, animal models of post-menopausal and diabetes-induced osteoporosis suggest black cumin seed oil may also be beneficial for bone loss. Superoxide radicals play a role in osteoclast activity, so potent antioxidants may be helpful in supporting proper bone turnover.30 Compared to controls, ovariectomized rats treated with black cumin seed oil before and after ovariectomy showed favorable changes in markers for bone turnover, including serum calcium levels and alkaline phosphatase, and the inflammatory markers TNF-a and IL-6.31

Annatto Tocotrienols References
1. Khor HT, Ng TT. Effects of administration of alpha-tocopherol and tocotrienols on serum lipids and liver HMG CoA reductase activity. Int J Food Sci Nutr. 2000;51 Suppl:S3-11.

2. Qureshi AA, Pearce BC, Nor RM, Gapor A, Peterson DM, Elson CE. Dietary alphatocopherol attenuates the impact of gamma-tocotrienol on hepatic 3-hydroxy-3methylglutaryl coenzyme A reductase activity in chickens. J Nutr. 1996 Feb;126(2):38994.

3. Shibata A, Nakagawa K, Sookwong P, Tsuduki T, Asai A, Miyazawa T. alpha-Tocopherol attenuates the cytotoxic effect of delta-tocotrienol in human colorectal adenocarcinoma cells. Biochem Biophys Res Commun. 2010 Jun 25;397(2):214-9.

4. Sen CK1, Khanna S, Roy S. Tocotrienols in health and disease: the other half of the natural vitamin E family. Mol Aspects Med. 2007 Oct-Dec;28(5-6):692-728.

5. Schaffer S, Müller WE, Eckert GP. Tocotrienols: constitutional effects in aging and disease. J Nutr. 2005 Feb;135(2):151-4.

6. Sen CK, Khanna S, Roy S. Tocotrienol: the natural vitamin E to defend the nervous system? Ann N Y Acad Sci. 2004 Dec;1031:127-42.

7. Sen CK1, Khanna S, Roy S, Packer L. Molecular basis of vitamin E action. Tocotrienol potently inhibits glutamate-induced pp60(c-Src) kinase activation and death of HT4 neuronal cells. J Biol Chem. 2000 Apr 28;275(17):13049-55.

8. Mangialasche F, et al. Tocopherols and tocotrienols plasma levels are associated with cognitive impairment. Neurobiol Aging. 2012 Oct;33(10):2282-90.

9. Mangialasche F, et al. Classification and prediction of clinical diagnosis of Alzheimer's disease based on MRI and plasma measures of a-/?-tocotrienols and ?-tocopherol. J Intern Med. 2013 Jun;273(6):602-21.

10. Frank J, Chin XW, Schrader C, Eckert GP, Rimbach G. Do tocotrienols have potential as neuroprotective dietary factors? Ageing Res Rev. 2012 Jan;11(1):163-80.

11. Sylvester PW, Wali VB, Bachawal SV, Shirode AB, Ayoub NM, Akl MR. Tocotrienol combination therapy results in synergistic anticancer response. Front Biosci (Landmark Ed). 2011 Jun 1;16:3183-95.

12. Nesaretnam K, Selvaduray KR, Abdul Razak G, Veerasenan SD, Gomez PA. Effectiveness of tocotrienol-rich fraction combined with tamoxifen in the management of women with early breast cancer: a pilot clinical trial. Breast Cancer Res. 2010;12(5):R81.

13. Aggarwal BB, Sundaram C, Prasad S, Kannappan R. Tocotrienols, the vitamin E of the 21st century: its potential against cancer and other chronic diseases. Biochem Pharmacol. 2010 Dec 1;80(11):1613-31.

14. Sylvester PW, Kaddoumi A, Nazzal S, El Sayed KA. The value of tocotrienols in the prevention and treatment of cancer. J Am Coll Nutr. 2010 Jun;29(3 Suppl):324S-333S.

15. Viola V, et al. Why tocotrienols work better: insights into the in vitro anti-cancer mechanism of vitamin E. Genes Nutr. Jan 2012; 7(1):29-41.

16. Wada S, Satomi Y, Murakoshi M, Noguchi N, Yoshikawa T, Nishino H. Tumor suppressive effects of tocotrienol in vivo and in vitro. Cancer Lett. 2005 Nov 18;229(2):181-91.

17. Fernandes NV1, Guntipalli PK, Mo H. d-d-Tocotrienol-mediated cell cycle arrest and apoptosis in human melanoma cells. Anticancer Res. 2010 Dec;30(12):4937-44.

18. Hodul PJ, et al. Vitamin E d-tocotrienol induces p27(Kip1)-dependent cell-cycle arrest in pancreatic cancer cells via an E2F-1-dependent mechanism. PLoS One. 2013;8(2):e52526.

19. Husain K, Francois RA, Yamauchi T, Perez M, Sebti SM, Malafa MP. Vitamin E dtocotrienol augments the antitumor activity of gemcitabine and suppresses constitutive NF-?B activation in pancreatic cancer. Mol Cancer Ther. 2011 Dec;10(12):2363-72.

20. Nesaretnam K, Gomez PA, Selvaduray KR, Razak GA. Tocotrienol levels in adipose tissue of benign and malignant breast lumps in patients in Malaysia. Asia Pac J Clin Nutr. 2007;16(3):498-504.

21. Pierpaoli E, Viola V, Barucca A, Orlando F, Galli F, Provinciali M. Effect of annattotocotrienols supplementation on the development of mammary tumors in HER-2/neu transgenic mice. Carcinogenesis. 2013 Jun;34(6):1352-60.

22. Aftab A., et al. A review on therapeutic potential of Nigella sativa: A miracle herb. Asian Pac J Trop Biomed. May 2013; 3(5): 337–352.

23. V. Tembhurne, S. Feroz, B. H. More, D. M.Sakarkar. A review on therapeutic potential of Nigella sativa (kalonji) seeds. Journal of Medicinal Plants Research. Vol. 8(3), 167-177. Jan 2014.

24. Hajhashemi V, Ghannadi A, Jafarabadi H. Black cumin seed essential oil, as a potent analgesic and antiinflammatory drug. Phytother Res. 2004 Mar;18(3):195-9.

25. Baser KH. Biological and pharmacological activities of carvacrol and carvacrol bearing essential oils. Curr Pharm Des. 2008;14(29):3106-19.

26. Salem ML. Immunomodulatory and therapeutic properties of the Nigella sativa L. seed. Int Immunopharmacol. 2005 Dec;5(13-14):1749-70.

27. Woo CC, Kumar AP, Sethi G, Tan KH. Thymoquinone: potential cure for inflammatory disorders and cancer. Biochem Pharmacol. 2012 Feb 15;83(4):443-51.

28. Gheita TA, Kenawy SA. Effectiveness of Nigella sativa oil in the management of rheumatoid arthritis patients: a placebo controlled study. Phytother Res. 2012 Aug;26(8):1246-8.

29. Banerjee S, Padhye S, Azmi A, Wang Z, Philip PA, Kucuk O, Sarkar FH, Mohammad RM. Review on molecular and therapeutic potential of thymoquinone in cancer. Nutr Cancer. 2010;62(7):938-46.

30. Ansari, R and Batra, NG. Effects of Nigella sativa against osteoporosis. Int. J. Pure App. Biosci. 1 (2): 6-14 (2013).

31. Seif AA. Nigella Sativa reverses osteoporosis in ovariectomized rats. BMC Complement Altern Med. 2014; 14: 22.

UPC 87945200153
Manufacturer: DFH

Customer Reviews
Average Rating on 6 Reviews
(05 stars in 6 rating(s))
5 star rating tocotrienols 11/20/2014 Annatto Tocotrienols with Black Cumin Seed Oil by Designs For Health (DFH)5
Reviewed by Jo from Houston.
This is an almost odorless, refined tocotrienol that is one of the few food supplements I have been able to tolerate. It has reduced my background level of joint inflammation and increased my sense of well-being.

5 star rating Annatto tocotrienols 6/16/2011 Annatto Tocotrienols with Black Cumin Seed Oil by Designs For Health (DFH)5
Reviewed by Lynn Eroh from Selinsgrove, PA 17870.
I am very happy with the results that I have achieved with your product. it is exactly what I needed to help with my health. It is a wonderfully, pure, potent product!

5 star rating Annatto Tocotrienols 11/18/2009 Annatto Tocotrienols with Black Cumin Seed Oil by Designs For Health (DFH)5
Reviewed by David from US.
Delivered timely, this is a good product

5 star rating DFH 6/7/2009 Annatto Tocotrienols with Black Cumin Seed Oil by Designs For Health (DFH)5
Reviewed by David from US.
delivered timely and accurately

5 star rating Annatto Tocotrienols 9/5/2008 Annatto Tocotrienols with Black Cumin Seed Oil by Designs For Health (DFH)5
Reviewed by Bud Kronfly from La Quinta, California.
My doctor recommended moderate diet control and exercise along with Annatto Tocotrienols as a supplement to control cholesterol levels and blood pressure. This has avoided the taking of any prescribed medicines to support this effort.

5 star rating Annatto Tocotrienols 7/22/2008 Annatto Tocotrienols with Black Cumin Seed Oil by Designs For Health (DFH)5
Reviewed by Bud Kronfly from La Quinta/California.
Over the past few years the Annatto Tocotrienols supplements along with exercise and moderate diet control have maintained my Cholesterol and blood pressure at a level directed by my doctor. He recommends these supplements along with your other product "Ultra Trieonols Plus".

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