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Annatto Tocotrienols with Black Cumin Seed Oil by Designs For Health (DFH)

60 softgels
Today's Price:
$49.90

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Cannot be shipped outside the US

Annatto Tocotrienols with Black Cumin Seed Oil

Annatto Tocotrienols is a unique tocopherol-free, tocotrienols-only product, containing 125mg tocotrienols along with 1g black cumin seed oil (Nigella sativa) per two softgel serving. The synergistic combination of tocotrienols and black cumin makes it most efficacious for supporting cardiovascular health and defending against oxidative stress.

The tocotrienols are extracted from the South American annatto bean and contain 90% delta-tocotrienol and 10% gamma-tocotrienol. For best results, this product should not be taken within six hours of taking a vitamin E supplement containing d-alpha tocopherol.

Annatto Tocotrienols with black cumin seed oil may help support*:
  • cardiovascular function
  • cholesterol levels that are already within the normal range
  • antioxidant protection
  • immune function

Supplement Facts
Serving Size 2 softgels
Servings Per Container 30

Amount Per Serving
Black Cumin Seed Oil (Nigella sativa)(seed) 1 g
Tocotrienols (delta, gamma) 125 mg

Other Ingredients: Medium chain triglycerides; bovine gelatin, glycerine, purified water, annatto (natural color) (softgel ingredients).

Recommended Use: As a dietary supplement, take two softgels per day, or as directed by your health care practitioner.

Does not contain gluten. Notice: Color, size or shape may appear different between lots.

STORE AT ROOM TEMPERATURE. KEEP OUT OF REACH OF CHILDREN.

*All raw materials have been reviewed and validated by DFH QC to be non-GMO (based on supplier documentation)

Annatto Tocotrienols References
1. Khor HT, Ng TT. Effects of administration of alpha-tocopherol and tocotrienols on serum lipids and liver HMG CoA reductase activity. Int J Food Sci Nutr. 2000;51 Suppl:S3-11.

2. Qureshi AA, Pearce BC, Nor RM, Gapor A, Peterson DM, Elson CE. Dietary alphatocopherol attenuates the impact of gamma-tocotrienol on hepatic 3-hydroxy-3methylglutaryl coenzyme A reductase activity in chickens. J Nutr. 1996 Feb;126(2):38994.

3. Shibata A, Nakagawa K, Sookwong P, Tsuduki T, Asai A, Miyazawa T. alpha-Tocopherol attenuates the cytotoxic effect of delta-tocotrienol in human colorectal adenocarcinoma cells. Biochem Biophys Res Commun. 2010 Jun 25;397(2):214-9.

4. Sen CK1, Khanna S, Roy S. Tocotrienols in health and disease: the other half of the natural vitamin E family. Mol Aspects Med. 2007 Oct-Dec;28(5-6):692-728.

5. Schaffer S, Müller WE, Eckert GP. Tocotrienols: constitutional effects in aging and disease. J Nutr. 2005 Feb;135(2):151-4.

6. Sen CK, Khanna S, Roy S. Tocotrienol: the natural vitamin E to defend the nervous system? Ann N Y Acad Sci. 2004 Dec;1031:127-42.

7. Sen CK1, Khanna S, Roy S, Packer L. Molecular basis of vitamin E action. Tocotrienol potently inhibits glutamate-induced pp60(c-Src) kinase activation and death of HT4 neuronal cells. J Biol Chem. 2000 Apr 28;275(17):13049-55.

8. Mangialasche F, et al. Tocopherols and tocotrienols plasma levels are associated with cognitive impairment. Neurobiol Aging. 2012 Oct;33(10):2282-90.

9. Mangialasche F, et al. Classification and prediction of clinical diagnosis of Alzheimer's disease based on MRI and plasma measures of a-/?-tocotrienols and ?-tocopherol. J Intern Med. 2013 Jun;273(6):602-21.

10. Frank J, Chin XW, Schrader C, Eckert GP, Rimbach G. Do tocotrienols have potential as neuroprotective dietary factors? Ageing Res Rev. 2012 Jan;11(1):163-80.

11. Sylvester PW, Wali VB, Bachawal SV, Shirode AB, Ayoub NM, Akl MR. Tocotrienol combination therapy results in synergistic anticancer response. Front Biosci (Landmark Ed). 2011 Jun 1;16:3183-95.

12. Nesaretnam K, Selvaduray KR, Abdul Razak G, Veerasenan SD, Gomez PA. Effectiveness of tocotrienol-rich fraction combined with tamoxifen in the management of women with early breast cancer: a pilot clinical trial. Breast Cancer Res. 2010;12(5):R81.

13. Aggarwal BB, Sundaram C, Prasad S, Kannappan R. Tocotrienols, the vitamin E of the 21st century: its potential against cancer and other chronic diseases. Biochem Pharmacol. 2010 Dec 1;80(11):1613-31.

14. Sylvester PW, Kaddoumi A, Nazzal S, El Sayed KA. The value of tocotrienols in the prevention and treatment of cancer. J Am Coll Nutr. 2010 Jun;29(3 Suppl):324S-333S.

15. Viola V, et al. Why tocotrienols work better: insights into the in vitro anti-cancer mechanism of vitamin E. Genes Nutr. Jan 2012; 7(1):29-41.

16. Wada S, Satomi Y, Murakoshi M, Noguchi N, Yoshikawa T, Nishino H. Tumor suppressive effects of tocotrienol in vivo and in vitro. Cancer Lett. 2005 Nov 18;229(2):181-91.

17. Fernandes NV1, Guntipalli PK, Mo H. d-d-Tocotrienol-mediated cell cycle arrest and apoptosis in human melanoma cells. Anticancer Res. 2010 Dec;30(12):4937-44.

18. Hodul PJ, et al. Vitamin E d-tocotrienol induces p27(Kip1)-dependent cell-cycle arrest in pancreatic cancer cells via an E2F-1-dependent mechanism. PLoS One. 2013;8(2):e52526.

19. Husain K, Francois RA, Yamauchi T, Perez M, Sebti SM, Malafa MP. Vitamin E dtocotrienol augments the antitumor activity of gemcitabine and suppresses constitutive NF-?B activation in pancreatic cancer. Mol Cancer Ther. 2011 Dec;10(12):2363-72.

20. Nesaretnam K, Gomez PA, Selvaduray KR, Razak GA. Tocotrienol levels in adipose tissue of benign and malignant breast lumps in patients in Malaysia. Asia Pac J Clin Nutr. 2007;16(3):498-504.

21. Pierpaoli E, Viola V, Barucca A, Orlando F, Galli F, Provinciali M. Effect of annattotocotrienols supplementation on the development of mammary tumors in HER-2/neu transgenic mice. Carcinogenesis. 2013 Jun;34(6):1352-60.

22. Aftab A., et al. A review on therapeutic potential of Nigella sativa: A miracle herb. Asian Pac J Trop Biomed. May 2013; 3(5): 337–352.

23. V. Tembhurne, S. Feroz, B. H. More, D. M.Sakarkar. A review on therapeutic potential of Nigella sativa (kalonji) seeds. Journal of Medicinal Plants Research. Vol. 8(3), 167-177. Jan 2014.

24. Hajhashemi V, Ghannadi A, Jafarabadi H. Black cumin seed essential oil, as a potent analgesic and antiinflammatory drug. Phytother Res. 2004 Mar;18(3):195-9.

25. Baser KH. Biological and pharmacological activities of carvacrol and carvacrol bearing essential oils. Curr Pharm Des. 2008;14(29):3106-19.

26. Salem ML. Immunomodulatory and therapeutic properties of the Nigella sativa L. seed. Int Immunopharmacol. 2005 Dec;5(13-14):1749-70.

27. Woo CC, Kumar AP, Sethi G, Tan KH. Thymoquinone: potential cure for inflammatory disorders and cancer. Biochem Pharmacol. 2012 Feb 15;83(4):443-51.

28. Gheita TA, Kenawy SA. Effectiveness of Nigella sativa oil in the management of rheumatoid arthritis patients: a placebo controlled study. Phytother Res. 2012 Aug;26(8):1246-8.

29. Banerjee S, Padhye S, Azmi A, Wang Z, Philip PA, Kucuk O, Sarkar FH, Mohammad RM. Review on molecular and therapeutic potential of thymoquinone in cancer. Nutr Cancer. 2010;62(7):938-46.

30. Ansari, R and Batra, NG. Effects of Nigella sativa against osteoporosis. Int. J. Pure App. Biosci. 1 (2): 6-14 (2013).

31. Seif AA. Nigella Sativa reverses osteoporosis in ovariectomized rats. BMC Complement Altern Med. 2014; 14: 22.


UPC 87945200153
Manufacturer: DFH
SKU: ANTS60


Customer Reviews
Average Rating on 5 Reviews
(05 stars in 5 rating(s))
5 star rating tocotrienols 11/20/2014 Annatto Tocotrienols with Black Cumin Seed Oil by Designs For Health (DFH)5
Reviewed by Jo from Houston.
This is an almost odorless, refined tocotrienol that is one of the few food supplements I have been able to tolerate. It has increased my sense of well-being.

5 star rating Annatto tocotrienols 6/16/2011 Annatto Tocotrienols with Black Cumin Seed Oil by Designs For Health (DFH)5
Reviewed by Lynn Eroh from Selinsgrove, PA 17870.
I am very happy with the results that I have achieved with your product. it is exactly what I needed to help with my health. It is a wonderfully, pure, potent product!

5 star rating Annatto Tocotrienols 11/18/2009 Annatto Tocotrienols with Black Cumin Seed Oil by Designs For Health (DFH)5
Reviewed by David from US.
Delivered timely, this is a good product

5 star rating DFH 6/7/2009 Annatto Tocotrienols with Black Cumin Seed Oil by Designs For Health (DFH)5
Reviewed by David from US.
delivered timely and accurately

5 star rating Annatto Tocotrienols 9/5/2008 Annatto Tocotrienols with Black Cumin Seed Oil by Designs For Health (DFH)5
Reviewed by Bud Kronfly from La Quinta, California.
My doctor recommended moderate diet control and exercise along with Annatto Tocotrienols as a supplement for cardiovascular support.

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