Designed to maintain healthy insulin and blood sugar levels
GlucoSupreme™ Herbal was designed to maintain steady blood sugar levels. It combines some of the most well-researched botanicals for blood sugar management (gymnema, fennugreek, banaba, cinnamon, and American ginseng), with unique herbals (salacia and kudzu), which have more recently emerged in the literature, demonstrating impressive efficacy in the optimization of blood sugar control in both normal subjects and those with metabolic syndrome and diabetes.
GlucoSupreme™ Herbalcontains standardized compounds, which include:
Corosolic acid from Banaba
Isoflavones from Kudzu
Ginsenosides from American Ginseng
Saponins from Fennugreek
Gymnemic acid from Gymnema
The ayurvedic herb Salacia exerts an effect on both leptin and insulin signaling
Cinnamon cassia extract, which naturally contains chromium and polyphenols proven to have direct effects on insulin and glucose. Its actives have many roles including antioxidant and even anti-inflammatory effects. Both, cinnamon and salacia are bio-assayed for alpha-amylase inhibition.
GlucoSupreme™ Herbal is safe for obesity, types 1 and 2 diabetes, metabolic syndrome, lipid abnormalities, and PCOS.
This product may be used along with prescription medication if monitored closely by a qualified health care practitioner.
Serving Size: 4 capsules
Salacia (Salacia oblonga) 500 mg (root and stems)(extract 10:1)
Other Ingredients: Microcrystalline cellulose, rice flour, magnesium stearate.
Recommended Use: As a dietary supplement, take two capsules two times daily with meals, or as directed by your health care practitioner.
This product does not contain: wheat, yeast, soy, gluten, eggs, dairy, corn, artificial colors, flavors, sugars, or preservatives.
WARNING: Use only under the supervision of a qualified health care provider who can actively monitor your blood sugar levels if you are diabetic and/or are also using blood sugar modulating medication or insulin.
STORE IN A COOL, DRY PLACE. KEEP OUT OF REACH OF CHILDREN.
CALIFORNIA RESIDENTS PLEASE NOTE:
This product is on the Proposition 65 Warning List
This synergistic product was designed to maintain steady blood sugar levels. GlucoSupreme? Herbal is ideal for patients with insulin and glucose-related conditions. It combines some of the most well-researched botanicals for blood sugar management (Gymnema, Fennugreek, Banaba, Cinnamon, and American ginseng), with unique herbals (Salacia and Kudzu), which have more recently emerged in the literature demonstrating impressive efficacy in the optimization of blood sugar control in both normal subjects and those with metabolic syndrome and diabetes.
It contains standardized compounds such as corosolic acid from Banaba, ginsenosides from Ginseng and saponins from Fennugreek. Cinnamon naturally contains chromium and polyphenols proven to have direct effects on insulin signaling and glucose control. Our specially chosen Cinnamon cassia extract is bio-assayed for alpha-amylase inhibition, as is the Salacia, and is standardized to a significant content of polyphenols. It is even kosher certified. Salacia oblonga, an ayurvedic herb, exerts an effect on both leptin and insulin signaling. Leptin (from the Greek word leptos meaning thin) is a hormone that plays a key role in regulating energy intake and energy expenditure, including appetite and metabolism.
More about Salacia Salacia (Salacia oblonga) roots have been used in Ayurvedic medicine for diabetes and obesity since antiquity. Recent pharmacological studies have demonstrated that Salacia roots modulate multiple targets: peroxisome proliferator-activated receptor-alpha-mediated lipogenic gene transcription, angiotensin II/angiotensin II type 1 receptor, alpha-glucosidase, aldose reductase and pancreatic lipase. These multitarget actions may mainly contribute to the reported Salacia root-induced improvement of type-2 diabetes and obesity-associated hyperglycemia, dyslipidemia and related cardiovascular complications.
A large body of data from cellular, biochemical, mouse and human genetic and chemical inhibitor studies have identified Protein Tyrosine Phosphatase 1B (PTP 1B) as a major regulator of both leptin and insulin signaling. Available research evidence suggests that leptin and insulin action can be enhanced by the inhibition of PTP 1B. Consequently, PTP 1B has emerged as an attractive novel target for the treatment of both obesity and type-2 diabetes. The link between PTP 1B, obesity and diabetes has led to an avalanche of research dedicated to finding inhibitors of this 1 phosphatase enzyme, including Salacia.
Fennugreek Fennugreek (Trigonella foenum-graecum) has a long history of many uses in Indian and Chinese medicine. Data from pre-clinical studies and small human investigations suggest that fennugreek possesses both acute and chronic hypoglycemic properties. Concomitant use with other hypoglycemic agents may lower serum glucose more dramatically and levels should be monitored closely. A study in trained male cyclists revealed that fennugreek seeds may increase muscle glycogen concentration immediately post exercise, thereby lowering serum glucose by stimulating muscle glucose uptake. Fennugreek may also slow the absorption of glucose, and other simple carbohydrates, due to its mucilaginous fiber content and high viscosity in the gut. Based on animal and in vitro studies, fennugreek may lower triglycerides, total cholesterol, and low density lipoprotein (LDL) levels (10-13).
American ginseng Various studies report a blood sugar-lowering effect of American ginseng (Panax quinquefolium) in individuals with type 2 diabetes, both on fasting blood glucose and on postprandial glucose levels. Research is ongoing to evaluate long-term efficacy of American ginseng in treating type-2 diabetes compared to standard oral hypoglycemic drugs. American ginseng is difficult to cultivate, however, Canada now grows more American ginseng than any other country. In the United States, most American ginseng is cultivated in Wisconsin (14-16).
Gymnema Gymnema (Gymnema sylvestre) leaves have been used for more than 2,000 years in India to treat madhu meha, or "honey urine." Preliminary human evidence suggests that gymnema may be efficacious for the management of serum glucose levels in type-1 and type-2 diabetes and as an adjunct to conventional drug therapy. Gymnema appears to lower serum glucose and glycosylated hemoglobin (HbA1c) levels following chronic use, but may not have as significant acute effects (17-19). There is also early evidence suggesting possible efficacy of gymnema as a lipid-lowering agent (20).
Banaba Banaba (Lagerstroemia speciosa) is a medicinal plant that grows in India, Southeast Asia, and the Philippines. The main mechanism of the hypoglycemic effect of banaba leaf extract is similar to that of insulin, in that it induces glucose transport from the blood into body cells to be burned as energy. Currently, research suggests that orally administered banaba extract, standardized to 1% corosolic acid, lowers blood sugar in people with type-2 diabetes (21-22). The Banaba chosen for GlucoSupreme? Herbal is standardized to 1% corosolic acid.
Kudzu Kudzu (Pueraria lobata) originated in China and was brought to the United States from Japan in the late 1800s. It is distributed throughout much of the eastern United States and is most common in the southern part of the continent. Type-2 diabetes is typically preceded by insulin resistance, so reversing insulin resistance may lessen chances of developing Type-2 diabetes. In a recent study of seventy-six patients with coronary heart disease the authors concluded that kudzu may improve insulin resistance and insulin resistance-related lipid and fibrinolytic activity abnormality (23).
Cinnamon Our specially chosen Cinnamon cassia extract is bio-assayed for alpha-amylase inhibition, as is the Salacia, and is standardized to a significant content of bioactive polyphenols. It is also kosher certified. Some of the best research was done using the cassia type cinnamon. The chromium and polyphenols naturally found in cinnamon have been shown to have the following mechanisms of action:
Trigger insulin cascade by initiating phosphorylation at the insulin receptor
Improve insulin-regulated glucose utilization
Enhance insulin signaling in skeletal muscle
Aid glucose to glycogen conversion
The antioxidant properties of cinnamon also make it efficacious for subjects with metabolic syndrome and diabetes, both of which are inflammatory disorders resulting in excessive oxidative stress (24-25).
Who should take GlucoSupreme Herbal? Those wishing to proactively maintain optimal blood sugar and those with dysglycemic conditions including metabolic syndrome, diabetes and polycystic ovary syndrome. GlucoSupreme? Herbal may be helpful for patients needing to lose weight and/or control lipids. This product should be taken under the guidance of a qualified health care practitioner. Consult with your health care provider before taking this product along with a blood sugar or diabetes medication.
Who should not take GlucoSupreme Herbal? This product should not be taken by pregnant or nursing women or by patients with known allergies to any of the herbs found in GlucoSupreme? Herbal.
Li, Yuhao, Huang, Tom Hsun-Wei, Yamahara, Johji. Salacia root, a unique Ayurvedic medicine, meets multiple targets in diabetes and obesity, Life Sciences (2008)
Huang TH, Yang Q, Harada M, Uberai J, Radford J, Li GQ, Yamahara J, Roufogalis BD, Li Y. Salacia oblonga root improves cardiac lipid metabolism in Zucker diabetic fatty rats: Modulation of cardiac PPAR-alpha-mediated transcription of fatty acid metabolic genes. Toxicol Appl Pharmacol. 2005 Aug 27; [Epub ahead of print]
Hsun-Wei Huang T, Peng G, Qian Li G, Yamahara J, Roufogalis BD, Li Y. Salacia oblonga root improves postprandial hyperlipidemia and hepatic steatosis in Zucker diabetic fatty rats: Activation of PPAR-alpha. Toxicol Appl Pharmacol. 2005 Jun 20; [Epub ahead of print]
Morikawa T, Kishi A, Pongpiriyadacha Y, Matsuda H, Yoshikawa M. Structures of new friedelane-type triterpenes and eudesmane-type sesquiterpene and aldose reductase inhibitors from Salacia chinensis. J Nat Prod. 2003 Sep; 66(9):1191-6.
Yoshikawa M, Shimoda H, Nishida N, Takada M, Matsuda H. Salacia reticulata and its polyphenolic constituents with lipase inhibitory and lipolytic activities have mild antiobesity effects in rats. J Nutr. 2002 Jul;132(7):1819-24.
Krishnakumar K, Augusti KT, Vijayammal PL. Hypoglycaemic and anti-oxidant activity of Salacia oblonga Wall. extract in streptozotocin-induced diabetic rats. Indian J Physiol Pharmacol. 1999 Oct;43(4):510-4.
Matsuda H, Murakami T, Yashiro K, Yamahara J, Yoshikawa M. Antidiabetic principles of natural medicines. IV. Aldose reductase and qlpha-glucosidase inhibitors from the roots of Salacia oblonga Wall. (Celastraceae): structure of a new friedelane-type triterpene, kotalagenin 16-acetate. Chem Pharm Bull (Tokyo). 1999 Dec;47(12):1725-9.
Shimoda H et al. Journal of the Japanese society of nutrition and food science. 1988,51,5:79-287.
Zhang Z.-Y. and Lee S-Y. Expert Opinion on Investigational Drugs, 2003:12:pp 223-233.
Raghuram TC, Sharma RD, Sivakumar B, and et al. Effect of fenugreek seeds on intravenous glucose disposition in non-insulin dependent diabetic patients. Phytotherapy Research 1994;8(2):83-86.
Bordia, A., Verma, S. K., and Srivastava, K. C. Effect of ginger (Zingiber officinale Rosc.) and fenugreek (Trigonella foenumgraecum L.) on blood lipids, blood sugar and platelet aggregation in patients with coronary artery disease. Prostaglandins Leukot Essent Fatty Acids 1997;56(5):379-384.
Sharma RD and Raghuram TC. Hypoglycaemic effect of fenugreek seeds in non-insulin dependent diabetic subjects. Nutr Res 1990;10:731-739.
Sharma RD, Raghuram TC, and Rao NS. Effect of fenugreek seeds on blood glucose and serum lipids in type I diabetes. Eur J Clin Nutrit 1990;44(4):301-306.
Milot, B. and Blumenthal, M. Asian and American Ginsengs Act Differently on Acute Glycemia. HerbalGram 2004;(64):24.
Blumenthal, M., Busse, W., Goldberg, A., and et al. The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. 1998;90.
World Health Organization. WHO Monographs on Selected Medicinal Plants. 1999;1:168.
Baskaran, K, Ahamath, BK, Shanmugasundaram, KR, and et all. Antidiabetic effect of a leaf extract from Gymnema sylvestre in non-insulin-dependent diabetes mellitus patients. J Ethnopharm 1990;30:295-305.
Cicero, A. F., Derosa, G., and Gaddi, A. What do herbalists suggest to diabetic patients in order to improve glycemic control? Evaluation of scientific evidence and potential risks. Acta Diabetol. 2004;41(3):91-98.
Grover, J. K., Yadav, S., and Vats, V. Medicinal plants of India with anti-diabetic potential. J Ethnopharmacol. 2002;81(1):81-100.
Bishayee, A and Chatterjee, M. Hypolipidaemic and antiatherosclerotic effects of oral gymnema sylvestre R. Br. leaf extract in albino rats fed a high fat diet. Phytother Res 1994;8:118-120.
Murakami, C., Myoga, K., Kasai, R., Ohtani, K., Kurokawa, T., Ishibashi, S., Dayrit, F., Padolina, W. G., and Yamasaki, K. Screening of plant constituents for effect on glucose transport activity in Ehrlich ascites tumour cells. Chem Pharm Bull.(Tokyo) 1993;41(12):2129-2131.
Judy, W. V., Hari, S. P., Stogsdill, W. W., Judy, J. S., Naguib, Y. M., and Passwater, R. Antidiabetic activity of a standardized extract (Glucosol) from Lagerstroemia speciosa leaves in Type II diabetics. A dose-dependence study. J Ethnopharmacol. 2003;87(1):115-117
Shi, W. G., Qu, L., and Wang, J. W. [Study on interventing effect of puerarin on insulin resistance in patients with coronary heart disease]. Zhongguo Zhong.Xi.Yi.Jie.He.Za Zhi. 2002;22(1):21-24.
Khan, A., Safdar, M., Ali Khan, M. M., Khattak, K. N., and Anderson, R. A. Cinnamon improves glucose and lipids of people with type 2 diabetes. Diabetes Care 2003;26(12):3215-3218.
Choi, J., Lee, K. T., Ka, H., Jung, W. T., Jung, H. J., and Park, H. J. Constituents of the essential oil of the Cinnamomum cassia stem bark and the biological properties. Arch Pharm Res 2001;24(5):418-423.