Inflammatone contains a combination of the immune supporting herbs and enzymes to help support wellness.
Inflammatone can be use for:
A healthy immune system and immune support
Gastric and Small Intestinal support
This powerful formula combines the best of science and enzyme technology for degrading fibrinolytic protein compounds produced in the body. The carefully chosen herbs have lipooxygenase (LOX) inhibition, COX 2 inhibition, only mild COX 1 inhibition (to avoid blood thinning and stomach sensitivity).
Other Ingredients: Rice bran, vegetable cellulose, and water.
Recommended Use As a dietary supplement, take two capsules daily, between meals, or as directed by your health care practitioner.
Store In A Cool, Dry Place. Keep Out Of Reach Of Children.
WARNING: Not recommended for use by pregnant or lactating women.
*All raw materials have been reviewed and validated by DFH QC to be non-GMO (based on supplier documentation)
Q: Are the capsules of Inflammatone enteric coated? If they are not enteric coated if the stomach acid breaks the enzymes down before they ever reach the intestines since one is suppose to take them on an empty stomach?
A: The enzymes in Inflammatone by DFH do not need to be enteric coated. Unlike enzymes from animal sources, enzymes derived from most microbial and plant sources (including those in Inflammatone) are stable throughout a broad pH range including the acidic pH found in the gastric region as well as the neutral to alkaline pH of the intestines. Most have a narrower range for maximal enzymatic activity, but they remain stable and minimally active within a very large range, some as wide as pH 2-10. The reason that the instructions for taking a product such as Inflammatone specify taking between meals is to optimize the amount of the active enzyme that can be absorbed and utilized in systemic circulation. Intestinal absorption of a large protein such as an enzyme is inefficient, which is one of the reasons that such high activity dosages are utilized in this type of product. If taken with meals the enzymes would preferentially use the food as a substrate and would be less likely to come in contact with the intestinal wall and be directly absorbed into circulation.
The proteolytic enzymes not only break down fibrinolytic proteins including kinins and fibrin but also enhance the breakdown and removal of damaged tissue and can improve lymphatic drainage. Inflammatone is safe to use in high doses yet powerful enough to provide results with as little as two capsules per day. For best results, this product should be taken on an empty stomach, approximately one hour before meals or several hours after.
Inflammatone : New & Improved
Designs for Health made this popular and effective formula even better. Why? Compelling research convinced us to make the following changes:
Increased dosages per capsule of the main herbs boswellia, turmeric and ginger [3,4]
Additional ingredients with these benefits:
the antioxidant/antiglycating flavonoid rutin 
the powerful antioxidant compounds rosemary and resveratrol [6,7]
stronger, more targeted proteolytic enzyme mix with the addition of trypsin, chymotrypsin and Serrazymes
INFLAMMATONE INGREDIENTS TARGET MANY METABOLIC PATHWAYS OF A HEALTHY IMMUNE RESPONSE [1,2]:
1. Significant inhibition of the COX-2 (cyclooxygenase) enzyme, which produces prostaglandins PG-E2 and thromboxanes TX-A2 (vasoconstrictive and increases platelet aggregation). The COX-2 inhibition is achieved by turmeric, ginger, quercitin and resveratrol. The PG-E2 is also known to increase cell proliferation.
2. Additional inhibition of the expression of the COX-2 enzyme by antioxidant effects on NF-Kappa B, which is one of the regulators of the cytokine response. This is achieved by the antioxidant action of turmeric, quercitin, rutin, rosemary and resveratrol. This is a preferred mechanism of inhibition because it acts upstream in the metabolic pathway by reducing oxidative stress.
3. Inflammatone ingredients have a minimal inhibition of the COX-1 enzyme which has a maintenance function for a number of tissues in the body, including intestinal cells.
4. Inflammatone has a mild anti-thrombotic (blood thinning) effect, similar to that of aspirin. The blood thinning effect of Inflammatone is due to the following:
mild COX-1 inhibition by ginger and resveratrol
mild anti-coagulating activity of turmeric and quercitin
fibrinolytic effect of the proteolytic enzymes
5. In addition to inhibiting COX-2, some Inflammatone ingredients also inhibit the LOX (Lipooxygenase) enzyme. This enzyme is normally producing Leukotrienes (LT-4 series). The LOX inhibition is achieved by boswellia, turmeric, ginger, quercitin and resveratrol.
6. Inflammatone reduces the formation of leukotrienes (LT) in the first place as opposed to just blocking certain LT receptors.
7. Some of the Inflammatone ingredients were shown to block Phospholipase A2 (turmeric, ginger) or TNF-alpha (Quercitin) which is similar to what corticosteroids do.8. One other important reason Inflammatone may be better than the available selective anti-inflammatory drugs is that it combines many benefits in one, blocking many pathways at the same time. When any one drug is given, it only blocks one Arachidonic Acid (AA) pathway, for example VIOXX and Celebrex block only COX-2 which causes an overflow of AA into the other pathway, the LOX-1. That is why COX-2 inhibiting drugs are known to have side effects such as increased incidence of asthma.
Inflammatone works both on an empty stomach and with food but it has slightly different effects:
a. On an empty stomach, the proteolytic enzymes are absorbed partially in the circulation and clear out immune complexes that may accumulate in joints, airways, intestinal tract, and any tissue. Once absorbed in the blood stream, these proteolytic enzymes have a fibrinolytic effect.
b. When taken with food, the proteolytic enzymes will aid in protein digestion. This can help support any undigested peptides like gluten, casein, egg, soy, etc.
The array of proteolytic enzymes contained in Inflammatone were specifically chosen to have good activity over a very wide range of pH, characteristic of the stomach and intestinal environment.
Research shows that ingredients in Inflammatone may benefit immune, cellular, and gastric support .
For more information on Inflammatone by Designs for Health, please consult with our nutritionist (see Contact Us) or your health practitioner.
FitzGerald GA, Patrono C. The coxibs, selective inhibitors of cyclooxygenase-2. N Engl J Med. 2001 Aug 9;345(6):433-42
De Caterina R, Zampolli A. From asthma to atherosclerosis—5-lipoxygenase, leukotrienes, and inflammation. N Engl J Med. 2004 Jan 1;350(1):4-7
Ammon HP, Safayhi H . Mechanism of antiinflammatory actions of curcumine and boswellic acids. J Ethnopharmacol. 1993 Mar; 38(2-3): 113-9.
Kiuchi F, Iwakami S . Inhibition of prostaglandin and leukotriene biosynthesis by gingerols and diarylheptanoids. Chem Pharm Bull (Tokyo). 1992 Feb; 40(2): 387-91.
Guardia T, Rotelli AE . Anti-inflammatory properties of plant flavonoids. Effects of rutin, quercetin and hesperidin on adjuvant arthritis in rat. Farmaco. 2001 Sep;56(9):683-7.
Manna SK, Mukhopadhyay A. Resveratrol suppresses TNF-induced activation of nuclear transcription factors NF-kappa B, activator protein-1, and apoptosis: potential
Lo AH, Liang YC . Carnosol, an antioxidant in rosemary, suppresses inducible nitric oxide synthase through down-regulating nuclear factor-kappaB in mouse
Surh YJ. Anti-tumor promoting potential of selected spice ingredients with antioxidative and anti-inflammatory activities: a short review. Food Chem Toxicol 2002 role of reactive oxygen intermediates and lipid peroxidation. 1: J Immunol. 2000 Jun 15; 164(12): 6509-19. macrophages. Carcinogenesis. 2002 Jun;23(6):983-91. Aug;40(8):1091-7
Satoskar RR, Shah SJ . Evaluation of anti-inflammatory property of curcumin (diferuloyl methane) in patients with postoperative inflammation. Int J Clin Pharmacol Ther Toxicol. 1986 Dec; 24(12): 651-4
10/11/2012 Inflammatone 60 caps by Designs For Health (DFH)4
Reviewed by Ronald Scholar from Roseville, CA.
To soon to tell on the efficacy of the product, but Rockwell's prompt shipping and good prices are much appreciated.
6/22/2012 Inflammatone 60 caps by Designs For Health (DFH)1
Reviewed by Chrissy from Garrison, NY.
Unfortunately I did not see much of a difference while taking this product. I was taking 2 capsules twice a day. When I tried to reduce the amount of Advil I take (2 pills twice a day) I got worse.
1/9/2012 Inflammatone 60 caps by Designs For Health (DFH)5
Reviewed by Half court hilly from Pa.
Works great to remove excess fluids in your system.
2/28/2011 Inflammatone 60 caps by Designs For Health (DFH)5
Reviewed by momjam from Dickinson/TX.
This stuff works for me, and is not a man made cocktail of synthetics, but derived from ingredients found nature. If I doubt how much it helps, just like Peggy, i "remember" when I run out ;)
11/10/2010 Inflammatone 60 caps by Designs For Health (DFH)3
Reviewed by Bernard Brothman from Morris Plains / New Jersey.
I guess it works, as it does not hurt.
8/24/2010 Inflammatone 60 caps by Designs For Health (DFH)5
Reviewed by Peggy from Spring Hill, Florida.
I am very happy with the results of using Inflammatone.Once I thought "its no loger working" BUT when I ran out . . . I couldn't wait for the shipment to arrive! The friendliness of the staff at Rockwell is a nice bonus.
Keep up the greatwork!!!
8/13/2010 Inflammatone 60 caps by Designs For Health (DFH)5
Reviewed by booboo from san diego.
First of all, I love Designs for Health and secondly, I love Inflammatone. It was recommended to me by my nutritionist 2 yrs ago but I am unable to order through him as he's moved out of the country. Ordering through Rockwell was easy and friendly. Thank you.
7/27/2010 Inflammatone 60 caps by Designs For Health (DFH)5
Reviewed by theresa from east islip. ny.
I am still using this product for over one year. I feel it is helping
6/9/2010 Inflammatone 60 caps by Designs For Health (DFH)5
Reviewed by Liz from Richmond,TX.
This product was recommended to me by a N.D. Works great!
5/6/2010 Inflammatone 60 caps by Designs For Health (DFH)5
Reviewed by Francine du Pont from Wilmington, DE.
Recommended by Naturopath. Great product
11/18/2009 Inflammatone 60 caps by Designs For Health (DFH)5
Reviewed by theresa from suffolk county, ny.
I gave this product more time and I have to say it is starting to work. I will continue to try and hope for more releif.
7/22/2009 Inflammatone 60 caps by Designs For Health (DFH)1
Reviewed by theresa from suffolk county, NY.
I honestly have not noticed any difference since taking the inflammatone. I will continure to give it more time.
7/9/2009 Inflammatone 60 caps by Designs For Health (DFH)5
Reviewed by Janet from Sherman Oaks, CA.
This is a terrific product. I feel a positive shift in energy and have used it for a couple of weeks. I plan to continue to use it! Thank you for developing this product :)
working great so far
4/23/2009 Inflammatone 60 caps by Designs For Health (DFH)4
Reviewed by Martin from SF / CA.
my doctor actually suggested these in combination with medication have really helped. the combination works better than the meds alone. (that's not a medical opinion; i'm not a doctor, just a happy customer.)