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Thoroughly Clean Face Wash 8.5 oz by Dessert Essence
Thoroughly Clean Face Wash 8.5 oz by Dessert Essence
Rockwell Nutrition has gone GREEN!

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Vitalzym XE 180 caps by World Nutrition

180 Capsules
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World Nutrition's Vitalzym XE Capsules

Vitalzym XE is 2x as strong as the regular Vitalzym softgels.

Professional Strength Systemic Enzyme Supplement

  • All Natural
  • Non-Toxic
  • Non-GMO
  • Vegetarian Formula

Enzymes are the biocatalysts necessary for the chemical reactions associated with breathing, growth, reproduction, digestion, and all other metabolic functions. For most people under the age of 25, enzymes are sufficiently produced by the body to maintain optimal health. As we age, our bodys production of enzymes decreases. This reduction of enzyme levels may reduce the efficiency of our normal body functions.

Supplementation with systemic enzymes may help the body to more efficiently regulate its metabolism, thereby reducing the physiological effects of aging. Vxe is a unique blend of powerful systemic enzymes designed to assist the bodys normal metabolic processes.

Physicians in Europe and Asia have long prescribed systemic enzyme supplements to restore enzyme levels and promote natural healing. Combined with professional healthcare, proper diet and exercise, Vxe may help you to maintain proper enzyme levels and balance your bodys own repair mechanisms.

Videos on the powerful effects of these systemic enzymes:

Please see the More Info tab for further information on these excellent enzymes and how they work.

Serving Size: 3 capsules
Capsules Per Box: 180

Active Ingredients:
Proprietary Enzyme Blend 324 mg contains:

  • Bromelain
  • Papain
  • Rutin
  • Amylase
  • Protease
  • Lipase
  • Serrapeptase
  • Amla Extract

Other Ingredients: Medium-chain Triglycerides, Starch, Glycerin, Polysaccaride, pH Resistent Enteric Coating, Bees Wax, Glycerin Fatty Acid Ester, Riboflavin, Soy Lecithin and Citric Acid

Recommended Dosage:
As a dietary supplement, take 3 capsules daily with water. This dosage recommendation is for most users and your healthcare professional may recommend a higher activation amount.

Warning: If you are currently taking prescription drugs, consult your healthcare professional prior to use.

Serrapeptase, a key ingredient in Vxe, was originally discovered in Japan and is commercially produced there for health applications. It has been used as a substitute for animal-derived enzymes (such as chymotrypsin) because of its stronger effect of decomposing bradykinin. Bradykinin is a protein found in the body that causes an inflammatory response.
Serrapeptase must be enteric coated to bypass the stomach acids. Without a protective coating the enzyme will be destroyed by the stomach acids.

Bromelain is a plant-derived proteolytic enzyme most noted for its ability to break down proteins. Bromelain has been used therapeutically for over 50 years for its anti-inflammatory properties.

Papain is also a plant-derived enzyme used both systemically and in the digestive process to break down proteins.
Amylase is an enzyme that breaks down carbohydrates.

Lipase is an enzyme that breaks down lipids.

Rutin is a flavonoid that is used chiefly for strengthening capullary Blood vessels.

Amla, also known as the Indian gooseberry, is a rich source of Vitamin C.

Vxe also contains natural additives as part of the blending, stabilization, and enteric coating process. Vxe is all-natural and vegetarian. It does not contain talc or titanium dioxide.

100% Non-GMO ingredients.

Read customer questions and answers about systemic enzyme on our blog.

Vitalzym XE is recommended by healthcare professionals worldwide. The unique blend of vegetarian enzymes, flavonoids, and antioxidants has been formulated for 100% absorption in the small intestine.

All-Natural Enteric Coating

The effectiveness of any systemic enzyme is determined by the amount of activity level in the bloodstream after the enzyme has been absorbed from the small intestine. Enzymes that are susceptible to destruction in acidic conditions must be protected for delivery to the small intestine. Systemic enzymes will begin to lose their activity once introduced into the low pH (1.0-3.0) acids of the stomach. The amount of activity loss is dependent upon the individual enzyme and the amount of time it spends in the stomach. Studies have shown that unprotected enzymes can lose up to 100% of their activity in fewer than 30 minutes in pH levels below 3.0. The only reliable method of ensuring that 100% of the enzymes are not destroyed by the stomach acids is to enteric-coat the enzymes. Vxe has been formulated to use an enteric coated gel capsule manufactured under pharmaceutical-grade guidelines.*    

Vxe, serrapeptase, enzymes

Though revolutionary to nutritional enzyme blends, this enteric coating process is similar to that used in todays most advanced products. The capsule has an all-natural shell barrier that allows it to withstand the extremely low pH levels found in the stomach. Once introduced to the pancreatic juices in the duodenum (upper small intestine), the shell barrier breaks down to release the enzymes it contains. The enzymes are then absorbed into the bloodstream through the lining of the small intestine.* The enteric coated gel capsule has been designed to pass both the USP (United States Pharmacopeia) and JP (Japan Pharmacopeia) disintegration tests for enteric coated capsules. Every batch is tested to ensure it meets the agency guidelines before exportation to the U.S.*

Please see this great Enzyme Digestion Comparison chart/slides to better understand the enteric coating on this product: http://www.worldnutrition.info/enzyme-choices.

Image: Effect of pH on Enzyme Stability.

More Concentrated. More Activity. More Stability

Powder enzyme blends are available today that use an enteric coating, but they are typically in tablet form (see fig. 1). The disadvantage of these blends is the amount of heat created with compressing the ingredients into a tablet. Enzymes are susceptible to high temperatures and may begin to degrade during the manufacturing process.

Vxe is produced under strictly controlled temperature ranges and because of this our LiquidFilled Gel Capsules allow for an enteric coated enzyme to be developed without activity loss from heat.*

There are also enzyme formulations available in vegetable and gelatin capsules that claim to have an enteric coating (see fig. 2). An independent laboratory has put these to the test and has yet to find one that passes the US Pharmacopeia standard for enteric coating.

In fact, the best performing vegetable capsule tested lost more than 85% of its enzyme activity after being subjected to stomach conditions. In other words, less than 15% of its concentration was available for absorption to the bloodstream. Click here to see the results.

Liquid enzyme blends also provide a more uniform dose consistency, because the mixing of liquids allows for optimal particle distribution. In powder formulations, each particle of a different enzyme is different in size, causing greater friction between particles during mixing. Excipients are introduced to powder formulations to increase the mixability, but liquids still provide far more even distribution of ingredients, allowing for more consistent dosages in each capsule.*

Enzymes always retain some amount of moisture when they are produced. Enzymes, as proteins, are more susceptible to denaturation at higher moisture. Enzyme powders typically have lower (5-10%) moisture. However, even with lower moisture, enzyme powders will lose some of their activity over time, resulting in a loss of up to 20% of activity over a 12-month period. Vxe contains enzymes with a higher degree of purity and less moisture that, when combined with Medium-Chain Triglycerides (MCT), then decompressed during the manufacturing process, removes the moisture completely. As a result, loss of enzyme activity over time due to moisture will not occur after Vxe is produced. Vxe is manufactured to have a 5-year shelf life with no loss of activity when properly stored in a cool, dry place.*

Best Value

There are many cheap enzyme products available today. However, when comparing the value of each blend, Vxe continues to prove to be the least expensive option due to its unmatched efficacy. High concentrations of active, stable enzymes delivered to the bloodstream allows for the least amount of waste in an oral systemic enzyme supplement. When comparing the amount of pure enzymes delivered to the bloodstream for systemic effect, Vxe offers the best value of any systemic enzyme supplement available today.


  1. Carroll A., R.: Clinical examination of an enzymatic anti-inflammatory agent in emergency surgery. Arztl. Praxis 24 (1972), 2307.
  2. Mazzone A, et al.: Evaluation of Serratia peptidase in acute or chronic inflammation of otorhinolaryngology pathology: a multicentre, double blind, randomized trial versus placebo. J Int Med Res. 1990; 18(5):379-88.
  3. Kee W., H. Tan S, L., Lee V. Salmon Y. M.: The treatment of breast engorgement with Serrapeptase: a randomized double blind controlled trial. Singapore Med J. 1989:30(l):48-54.
  4. Celebrex article Wall Street Journal 19 April 1999.
  5. No author listed: Regular Use of Pain Relievers Can Have Dangerous Results. Kaleidoscope Interactive News, American Medical Association media briefing. July 24, 1997.
  6. Enzymes A Drug of the Future, Prof. Heinrich Wrba MD and Otto Pecher MD. Published 1993 Eco Med.
  7. Kakinumu A. et al.: Regression of fibrinolysis in scalded rats by administration of serrapeptase. Biochem. Pharmacol. 31:2861-2866,1982.
  8. Ernst E., Matrai A.: Oral Therapy with proteolytic enzymes for modifying blood rheology. Klin Wschr. 65 (1987), 994.
  9. Kunze R., Ransberger K., et at: Humoral immunomodulatory capacity of proteases in immune complex decomposition and formation. First International symposium on combination therapies, Washington, DC, 1991.
  10. Jager H.: Hydrolytic Enzymes in the therapy of HIV disease. Zeitschr. Allgemeinmed., 19 (1990), 160.
  11. Bartsch W.: The treatment of herpes zoster using proteolytic enzymes. Der Informierte Arzt. 2 (1974), 424-429.

Manufacturer: World Nutrition
SKU: 67180

Customer Reviews
Average Rating on 13 Reviews
(05 stars in 13 rating(s))
5 star rating vitalzyme 3/13/2015 Vitalzym XE 180 caps by World Nutrition5
Reviewed by bella from california.
I love this product. I have been using it for years for digestive issues. It works wonders!

5 star rating vitalzyme 11/18/2014 Vitalzym XE 180 caps by World Nutrition5
Reviewed by mary from mission viejo california.
Love this product. Have been using it for quite some time. I will continue to use it because it works!!

5 star rating Vitalzym 11/5/2014 Vitalzym XE 180 caps by World Nutrition5
Reviewed by joyis from iowa.
Been using Vitalzym since 2007. I don't believe it helps with inflammation as well in the last 2 years.

5 star rating review vitalzymxe 10/19/2014 Vitalzym XE 180 caps by World Nutrition5
Reviewed by peggy from Williston nd.
I found my ordering vitamins from rockwell a very pleasing experience. They got me exactly what I wanted in a profession manner. Thank you rockwell.

5 star rating Vitalzym Review 6/19/2014 Vitalzym XE 180 caps by World Nutrition5
Reviewed by jpkbalboa from Newport Beach.
Vitalzym is a great product and Rockwell is the place to get it. Price was great and ordering is easy.

5 star rating Another Small Ingredient for Healthy Living 6/15/2014 Vitalzym XE 180 caps by World Nutrition5
Reviewed by Oldma from Salt LakeCity.
My Health Practitioner started me on this about a year ago. I take one tab every morning on an empty stomach. My wholeohysical status has improved under her care over the last year. I think this enzyme tab is part of my overall improvement. Taken on an empty stomach, it helps to fight off the inflammatory process.

5 star rating Must have 4/18/2014 Vitalzym XE 180 caps by World Nutrition5
Reviewed by Lily from Toronto ON Canada.
This is a product you must always have in your cabinet in case of injury &/or aches & pains like those caused by joint issues. It was recommended to me by my naturopath & I've recommended it to others. Our naturopath increases the dosage during the critical phase & then we dose down until re-balance is achieved.

5 star rating Vitalzym XE 3/14/2014 Vitalzym XE 180 caps by World Nutrition5
Reviewed by fritzi from washington state and washington dc.
I think this product has helped to reduce the pain I was having from inflammation in my arms particularly

5 star rating Vitalzym XE 4/16/2013 Vitalzym XE 180 caps by World Nutrition5
Reviewed by AnnaBelle from Sweden.
I have fibroids and the Vitalzym XE has helped to shrink them and make them softer. It takes long time at least for me so one has to be patient and stick to it!

5 star rating VitalzymXe 8/29/2011 Vitalzym XE 180 caps by World Nutrition5
Reviewed by Gloria Biscardi from Los Angeles, CA.
I have been taking this product now for several years, and my immune system has improved dramatically as I get fewer colds and sore throats than before. Definitely reduces inflammation, which more and more is believed to be the cause of all disease.

5 star rating It helped with high urgency urinating problems 5/31/2011 Vitalzym XE 180 caps by World Nutrition5
Reviewed by Tommy N from Miami Beach.
I've had problems with extreme urgency going to the bathroom due to constrictions in the urinary tract that were caused by scar tissue building up. I used to do what we called the "pee-pee dance" while rushing to the rest room or waiting for it. Annika recommended I try Vitalzyme Xe to help work on the scar tissue, and it worked! My flow has improved greatly and I no longer have to do "the dance".

5 star rating Inflammation has decreased! 9/22/2010 Vitalzym XE 180 caps by World Nutrition5
Reviewed by Illania H from Atlanta GA.
I can feel less "congestion" in my body and know that the inflammation I was experiencing has descresed about 80% in a very short time. I expect to be pain free by the time I finish the box.

5 star rating This works! 9/15/2010 Vitalzym XE 180 caps by World Nutrition5
Reviewed by Daniel W from Quebec.
I was diagnosed with severe (RA) rheumatoid arthritis in Jan 2010, Doctor had me on 3 different NSAIDS, for 5 months, the swelling and pain was so severe i had trouble moving and getting out of bed, hands and feet really swollen, could not move my neck in any direction, the NSAIDS eventually worked but it soon became obvious I could not continue taking them as they were completely messing up my digestive cycle and my sleeping patterns. In June decided to try and replace the drugs with Vxe, its been 2 months now and the swelling has not reappeared and my condition has actually gotten better and I have completely stopped the NSAIDS, I took 5 caps a day for the first 45 days and am now I am on just 2 a day, in the process the Vxe seems to have cleansed my system to the point where I have shed almost 20 pounds and my energy level has really improved, I seem to wake earlier than usual without feeling tired and rusty like RA patients do in the mornings.

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